Results 21 to 30 of about 2,849 (172)

miR‐137 Inhibition of the Invasion, Metastasis, and Epithelial‐Mesenchymal Transition of Nasopharyngeal Cancer by Regulating KDM1A

Journal of Oncology, Volume 2021, Issue 1, 2021., 2021
One of the most frequent malignancies in the head and neck is nasopharyngeal carcinoma (NPC). MicroRNAs, a kind of tiny noncoding RNA molecule, have been used as negative regulators in different types of cancer therapy in recent decades by downregulating their targets.
Han-qiang Lu, Run-kun Wang, Hui-rong Wang, Guang-quan Zhou, Yan-shu Zhang, Ashok Pandurangan   +5 more
wiley   +1 more source

NM23-H1: a Metastasis-Associated Gene

Taiwanese Journal of Obstetrics and Gynecology, 2006
The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates. Reductions in nm23 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas.
Yi-Torng Tee, Gin-Den Chen, Long-Yau Lin, Jiunn-Liang Ko, Po-Hui Wang   +4 more
openaire   +3 more sources

Overexpression of nm23-H1 and nm23-H2 genes in colorectal carcinomas and loss of nm23-H1 expression in advanced tumour stages. [PDF]

Gut, 1995
Although a reduced expression of nm23 has been shown to correlate with a high metastatic potential in some human cancers, in colorectal cancers, conflicting data have been reported. As there are two homologous genes, nm23-H1 and nm23-H2, which encode the A and B subunits of nucleoside diphosphate kinase, efficient and simplified techniques were ...
J A, Martinez, S, Prevot, B, Nordlinger, T M, Nguyen, Y, Lacarriere, A, Munier, I, Lascu, J C, Vaillant, J, Capeau, M L, Lacombe   +9 more
openaire   +2 more sources

Transcriptome Analysis Reveals the Genes Involved in Growth and Metabolism in Muscovy Ducks

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Muscovy ducks are among the best meat ducks in the world. The objective of this study was to identify genes related to growth metabolism through transcriptome analysis of the ileal tissue of Muscovy ducks. Duck ileum samples with the highest (H group, n = 5) and lowest (L group, n = 5) body weight were selected from two hundred 70‐day‐old Muscovy ducks
Xingxin Wang, Yingping Xiao, Hua Yang, Lizhi Lu, Xiuting Liu, Wentao Lyu, Yong Feng   +6 more
wiley   +1 more source

Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis [PDF]

, 2004
We identify a new enzymatic activity underlying metastasis in breast cancer and describe its susceptibility to therapeutic inhibition. We show that human prune (h-prune), a phosphoesterase DHH family appertaining protein, has a hitherto unrecognized ...
Aglio V, André A, Aravind L, Arrigoni G, Carotenuto P, Cossu A, D'Angelo A, Garzia L, Guardiola O, Palmieri G, ZOLLO, MASSIMO   +10 more
core   +1 more source

TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders [PDF]

, 2008
Aicardi-Goutieres syndrome (AGS) is an unusual condition that clinically mimics a congenital viral infection. Several genes have recently been implicated in the aetiology of this disorder. One of these genes encodes the DNA exonuclease TREX1. Recent work
Aicardi, Akira, Alderton, Alderton, Bartek, Bartkova, Brennan, Brucet, Chen, Chowdhury, Crow, Crow, de Silva, DiTullio, Driscoll, Gasser, Griffith, Griffiths, Höss, Jazayeri, Kawai, Lee-Kirsch, Lee-Kirsch, Lieberman, Lieberman, Lindahl, Lindahl, Liu, Liu, Liu, Mark O’Driscoll, Martinvalet, Mazur, Mazur, Morita, Napirei, O’Driscoll, O’Driscoll, Qiu, Raulet, Rhodes, Rice, Richards, Shevelev, Stiff, Stiff, Takaoka, Tran, Tsukumo, Vyse, Walport, Yang, Yasutomo, Zou, Zou   +54 more
core   +1 more source

The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1 [PDF]

, 2002
Alterations in the activity of the centrosomal kinase, Aurora-A/STK15, have been implicated in centrosome amplification, genome instability and cellular transformation. How STK15 participates in all of these processes remains largely mysterious.
Du, J., Hannon, G. J.
core   +1 more source

Alcohol promotes breast cancer cell invasion by regulating the Nm23-ITGA5 pathway [PDF]

, 2011
Background Alcohol consumption is an established risk factor for breast cancer metastasis. Yet, the mechanism by which alcohol promotes breast cancer metastases is unknown.
Amy W Wong, Qiwei X Paulson, Jina Hong, Renee E Stubbins, Karen Poh, Emily Schrader, Nomeli P Nunez   +6 more
core   +1 more source

The metastasis suppressor Nm23 as a modulator of Ras/ERK signaling. [PDF]

, 2014
NM23-H1 (also known as NME1) was the first identified metastasis suppressor, which displays a nucleoside diphosphate kinase (NDPK) and histidine protein kinase activity.
Takács-Vellai, Krisztina
core   +1 more source

Clinical-translational strategies for the elevation of Nm23-H1 metastasis suppressor gene expression [PDF]

Molecular and Cellular Biochemistry, 2009
Interruption of the tumor metastatic process is a new, thought provoking molecular target for the treatment of cancer. The Nm23-H1 metastasis suppressor gene stands as a validated molecular target owing to its reduced expression in many aggressive human tumors, and the reduction in metastatic potential in vivo upon re-expression in multiple cell lines.
Jean-Claude, Marshall, Jong Heun, Lee, Patricia S, Steeg   +2 more
openaire   +2 more sources