Results 41 to 50 of about 2,849 (172)

Expression of nm23-H1 gene product in mediastinal lymph nodes from lung cancer patients [PDF]

European Journal of Cardio-Thoracic Surgery, 2001
Although numerous studies have shown that nm23-H1 gene product expression is inversely related to metastatic potential in some cancers, the expression in lymph nodes has not been studied in detail. An analysis of nm23-H1 gene product expression in mediastinal lymph nodes from lung cancer patients is reported.One hundred and thirty-four, randomly ...
M, Tomita, T, Ayabe, Y, Matsuzaki, T, Onitsuka   +3 more
openaire   +2 more sources

ERK1/2 mitogen‐activated protein kinase dimerization is essential for the regulation of cell motility

Molecular Oncology, Volume 19, Issue 2, Page 452-473, February 2025.
In mammary tumor cells, ERK dimerization is both necessary and sufficient for inducing cellular migration. The scaffold protein KSR1 is a critical element for endowing external agonists, acting through tyrosine kinase receptors, with the capacity to induce ERK dimerization and, subsequently, unleashing cellular motion, as a consequence of which tumor ...
Dalia de la Fuente‐Vivas, Vincenzo Cappitelli, Rocío García‐Gómez, Sara Valero‐Díaz, Camilla Amato, Javier Rodriguéz, Santiago Duro‐Sánchez, Alexander von Kriegsheim, Michael Grusch, José Lozano, Joaquín Arribas, Berta Casar, Piero Crespo   +12 more
wiley   +1 more source

Apoptosis: A Key Process That Trypanosoma cruzi Modulates as a Strategy to Perpetuate Infection

Journal of Parasitology Research, Volume 2025, Issue 1, 2025.
Apoptosis is a crucial host defense mechanism because it can trigger the immune response and get rid of infected cells. These important goals, among others, are achieved through a fine‐tuned process that culminates in a quiet form of cell death. Apoptosis represents a hindrance for intracellular microorganisms that live inside cells. Nevertheless, they
Diego Maurizio Coria-Paredes, Arturo A. Wilkins-Rodríguez, Laila Gutiérrez-Kobeh, Sarita Kumar   +3 more
wiley   +1 more source

General and Specific Promotion of Flagellar Assembly by a Flagellar Nucleoside Diphosphate Kinase [PDF]

, 2017
Nucleoside diphosphate kinases (NDKs) play a central role in diverse cellular processes using the canonical NDK activity or alternative mechanisms that remain poorly defined.
Ciruelas, Kristine S., Diener, Dennis R., Gopal, Radhika, Ishikawa, Takashi, King, Stephen M., Liu, Yi, Maizy, Yousif, Poghosyan, Emiliya, Yang, Pinfen, Zhu, Xiaoyan   +9 more
core   +1 more source

nm23-H1 Protein Expression and Gene Mutation in 150 Patients with Non-Hodgkin's Lymphomas [PDF]

Journal of Korean Medical Science, 2006
The metastasis-suppressing role of the nm23 gene in the metastatic spread of malignant tumor is still debated. We examined the nm23-H1 protein expression and gene mutation in non-Hodgkin's lymphomas to compare with the clinicopathologic parameters.
Lee, Ju-Han, Cho, Su Jin, Zhang, Xianglan, Zheng, Zhenlong, Lee, Eung Seok, Kim, Aeree, Kim, Young-Sik, Chae, Yang-seok, Kim, Insun   +8 more
openaire   +2 more sources

COVID‐19 vaccine adverse events: Evaluating the pathophysiology with an emphasis on sulfur metabolism and endotheliopathy

European Journal of Clinical Investigation, Volume 54, Issue 10, October 2024.
The focus of this narrative review is to assess the pathophysiology of severe adverse events observed after vaccination with DNA and mRNA vaccines against COVID‐19. It is viewed from the perspective of an undersulfated and degraded glycocalyx, considering its impact on immunomodulation, inflammatory responses, coagulation and oxidative stress ...
Heidi N. du Preez, Johnson Lin, Glenn E. M. Maguire, Colleen Aldous, Hendrik G. Kruger   +4 more
wiley   +1 more source

PuF, An Antimetastatic and Developmental Signaling Protein, Interacts with the Alzheimer’s Amyloid-β Precursor Protein via a Tissue-Specific Proximal Regulatory Element (PRE) [PDF]

, 2013
Background: Alzheimer’s disease (AD) is intimately tied to amyloid-β (Aβ) peptide. Extraneuronal brain plaques consisting primarily of Aβ aggregates are a hallmark of AD. Intraneuronal Aβ subunits are strongly implicated in disease progression.
Ge, Yuan-Wen, Lahiri, Debomoy K, Maloney, Bryan, Rogers, Jack Timothy   +3 more
core   +3 more sources

RETRACTED: Association between cathepsins and skin cancers: A bidirectional two‐sample Mendelian randomization study

Skin Research and Technology, Volume 30, Issue 8, August 2024.
Abstract Background Several cathepsins have been identified as being involved in the development of cancer. Nevertheless, the connection between cathepsins and skin cancers remained highly elusive. Methods A bidirectional Mendelian randomization (MR) analysis was performed to investigate the causal association between cathepsins and skin malignancies ...
Xinyi Ma, Haocheng Zhuang, Mingze Xu, Fangzhen Hou, Chunyu Xue   +4 more
wiley   +1 more source

New roles for the major human 3\u27–5\u27 exonuclease TREX1 in human disease [PDF]

, 2008
Aicardi-Goutières syndrome (AGS), Systemic Lupus Erythematosus (SLE), Familial Chilblain Lupus (FCL) and Retinal Vasculopathy and Cerebral Leukodystrophy (RVCL) {a new term encompassing three independently described conditions with a common etiology ...
Atkinson, John P, Kavanagh, David, Kothari, Parul H, Liszewski, M Kathryn, Richards, Anna, Shaikh, Aisha, Spitzer, Dirk   +6 more
core   +4 more sources

Inhibition of invasion and metastasis of human liver cancer HCCLM3 cells by portulacerebroside A [PDF]

CONTEXT: Portulacerebroside A (PCA) is a novel cerebroside compound isolated from Portulaca oleracea L. (Portulacaceae), an edible and medicinal plant distributed in the temperate and tropical zones worldwide.
Bago R, Cervoni L, Chen YG, Faried A, Gialeli C, Guo-Yin Zheng, Hai-Liang Xin, Hakem A, Hofer MD, Hofer MD, Hong Zhang, Iguchi K, Jian-Yu Chen, Jiang L, Johnson E, Jung S, Kar A, Khalid Rahman, Kumar A, Kumar R, Li YP, Liu M, Mardilovich K, McDermott WG, Novak M, Paul A, Qian Ji, Rathinam R, Rubaci AH, Struckhoff AP, Thakur RK, Toh Y, Ueno K, Valastyan S, Wei Xia, Xin HL, Xiong-Yu Meng, Yan J, Zhang H, Zhang H, Zheng GY, Zins K   +41 more
core   +1 more source