Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition. [PDF]
, 2018 Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma are responsible for their highly metastatic properties and poor patient survival rates.
Asadzadeh, F +40 more
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NDP Kinase Moves into Developing Primary Cilia [PDF]
, 2004 Inmunofluorescence staining of murine NIH3T3 fibroblasts grown at high density shows that conventional nucleoside diphosphate (NDP) kinases A and B localize to a sensory organelle, the primary cilium.
Gallagher, Betty C. +3 more
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Introduction of human SOS physiological functions-Suggestions for resolving problems due to radiation exposure at low doses [PDF]
, 2016 ストレス社会対応の新しい教室を15年間主宰すべく,次の基本理念の基,研究と教育およびアウトリーチ活動を行いました。即ち,「科学における創造とは,未知のものを既知化し,非常識のものを常識化する」という作業です。具体的には,私共の創造作業とは,突然変異という従来の概念を「変異には必然性有り」とする考えへと変更させるものでした。この変異の発生を調節するメカニズムの解明は,生命研究の根源的課題であります。SOS応答という基本概念での研究ストラテジーでした。但し,多くの工夫が必要でした。まずは,約20年間をかけて,
Deepshikha RoyChowdhury (2818678) +4 more
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Development of an aptamer-based biosensing system for measuring luteinizing hormone pulsatility for infertility treatment [PDF]
, 2014 Poster Presentation - Theme 1: Cell biologyNormal fertility in human involves a highly orchestrated signal communication between the hypothalamic-pituitary-gonadal. The pulsatile release of Luteinizing Hormone (LH) from pituitary gland is the key element
Liang, S, Tanner, JA
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Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines [PDF]
, 2014 Metastasis suppressor genes (MSGs) have contributed to an understanding of regulatory pathways unique to the lethal metastatic process. When re-expressed in experimental models, MSGs block cancer spread to, and colonization of distant sites without ...
Caplen, Natasha J. +10 more
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Nanoparticle delivery of anti-metastatic NM23-H1 gene improves chemotherapy in a mouse tumor model [PDF]
Cancer Gene Therapy, 2008 Gene therapy provides a promising approach for cancer treatment. Earlier studies suggested that poly-L-lysine-modified iron oxide nanoparticles (IONP-PLL) might be a promising gene delivery system that can transfect DNA efficiently in vitro and in vivo.
Z, Li +6 more
openaire +2 more sources
SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia [PDF]
, 2009 3 Tables. 7 Figures. The online version of this article contains a data supplement.Acute myeloid leukemias (AMLs) result from multiple genetic alterations in hematopoietic stem cells. We describe a novel t(12;18)(p13;q12) involving ETV6 in a patient with
Cristóbal, Ion +10 more
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Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]
, 2018 Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang +16 more
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The cystic fibrosis transmembrane recruiter the alter ego of CFTR as a multi-kinase anchor [PDF]
, 2007 This review focuses on a newly discovered interaction between protein kinases involved in cellular energetics, a process that may be disturbed in cystic fibrosis for unknown reasons.
Anil Mehta +52 more
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A humán metasztázis inhibitor nm23 géncsalád C. elegans ortológjainak genetikai analízise = A genetic characterisation of the human metastasis inhibitor nm23 orthologues in C. elegans [PDF]
, 2011 Az nm23 géncsalád első csoportjába tartozó gének nukleozid-difoszfát kinázokat (NDPK) kódolnak. Az első csoportba tartozó NDPK-ok C. elegans ortológját, az ndk-1 gént tanulmányoztuk, különös tekintettel a Ras/MAPK jelátvitelben betöltött szerepére.
Vellainé Takács, Krisztina
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