Results 121 to 130 of about 22,217 (292)

Voltage clamp analysis of nonlinear dendritic propertie in prepositus hypoglossi neurons [PDF]

open access: yesarXiv, 2010
The nonlinear properties of the dendrites in prepositus hypoglossi neurons are involved in maintenance of eye position. The biophysical properties of these neurons are essential for the operation of the vestibular neural integrator that converts a head velocity signal to one that controls eye position.
arxiv  

Neural integrator - a sandpile model [PDF]

open access: yesarXiv, 2006
We investigated a model for the neural integrator based on hysteretic units connected by positive feedback. Hysteresis is assumed to emerge from the intrinsic properties of the cells. We consider the recurrent networks containing either bistable or multistable neurons.
arxiv  

Modulation of the NMDA receptor by polyamines

open access: yesLife Sciences, 1991
Results of recent biochemical and electrophysiological studies have suggested that a recognition site for polyamines exists as part of the NMDA receptor complex. This site appears to be distinct from previously described binding sites for glutamate, glycine, Mg++,Zn++, and open-channel blockers such as MK-801.
Marc A. Dichter   +3 more
openaire   +3 more sources

Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Desensitization of N-Methyl-D-aspartate Receptor Channels

open access: yesJournal of Pharmacological Sciences, 2005
N-Methyl-D-aspartate (NMDA) receptors are a principal subtype of excitatory ligand-gated ion channels with crucial roles in a variety of physiological and pathological processes in the mammalian central nervous system (CNS).
Noritaka Nakamichi, Yukio Yoneda
doaj  

NORSE secondary to anti‐GAD65 antibody‐positive encephalitis treated with novel adjunctive rapid titration VNS protocol

open access: yesEpilepsia Open, EarlyView.
Abstract New Onset Refractory Status Epilepticus (NORSE) is a rare and severe condition characterized by refractory seizures in individuals without a prior history of epilepsy. This case report describes a 37‐year‐old woman diagnosed with anti‐glutamic acid decarboxylase 65 (anti‐GAD65) antibody‐positive encephalitis‐related NORSE.
Mingyu Li   +9 more
wiley   +1 more source

Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation

open access: yesNeurobiology of Disease, 2003
We analyzed NMDA receptor subunit mRNAs, proteins, and anchoring proteins in mice transgenic for exon 1 of the HD gene. R6/2 mice had decreased levels of mRNAs encoding ε1 and ε2 NMDA receptor subunits (mouse orthologs of rat NR2A and NR2B subunits), but
Ruth Luthi-Carter   +9 more
doaj  

Inherited metabolic epilepsies–established diseases, new approaches

open access: yesEpilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Tau is required for the function of extrasynaptic NMDA receptors

open access: yesScientific Reports, 2019
Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent ...
Noemí Pallas-Bazarra   +4 more
doaj   +1 more source

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