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NMDA Receptors as Voltage Sensors

2017
The membrane potential is an essential parameter of a living cell. However, measurements of the membrane potential using conventional techniques are associated with a number of artifacts. Cell-attached recordings of the currents through NMDA receptor channels enable noninvasive measurements of the neuronal membrane potential.
openaire   +4 more sources

NMDA receptors, cognition and schizophrenia – Testing the validity of the NMDA receptor hypofunction hypothesis

Neuropharmacology, 2012
Cognitive dysfunction is core to schizophrenia, and remains poorly treated by existing therapies. A prominent hypothesis suggests that many symptoms arise from N-methyl-d-aspartate receptor (NMDAR) hypofunction. Subsequently, there has emerged a widespread use of many preclinical and clinical NMDAR antagonist models in the search for novel treatments ...
Gilmour   +8 more
openaire   +2 more sources

NMDA receptors and memory encoding

Neuropharmacology, 2013
It is humbling to think that 30 years have passed since the paper by Collingridge, Kehl and McLennan showing that one of Jeff Watkins most interesting compounds, R-2-amino-5-phosphonopentanoate (d-AP5), blocked the induction of long-term potentiation in vitro at synapses from area CA3 of the hippocampus to CA1 without apparent effect on baseline ...
openaire   +2 more sources

The NMDA receptor

Journal of the Neurological Sciences, 1990
openaire   +2 more sources

The NMDA receptor

Journal of Epilepsy, 1991
openaire   +2 more sources

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

Nature Reviews Drug Discovery, 2006
Stuart A Lipton, Lipton Stuart A
exaly  

Novel NMDA receptor modulators: an update

Expert Opinion on Therapeutic Patents, 2012
Brooke M Katzman   +2 more
exaly  

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