Results 171 to 180 of about 94,075 (262)

Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect

Journal of Child Psychology and Psychiatry, EarlyView.
Background Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions.
Hanna C. Gustafsson, Hanna R. Wright, Jorden E. Jacinto Schreeder, Joel T. Nigg, Elinor L. Sullivan   +4 more
wiley   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post‐Traumatic Trigeminal Neuropathic Pain: A Real‐World Evidence Study

Journal of Oral Rehabilitation, EarlyView.
A compounded amitriptyline 10% plus lidocaine 2% mucoadhesive gel was associated with substantial pain improvement and favourable tolerability in adults with post‐traumatic trigeminal neuropathic pain (PTNP). These findings support targeted mucosal delivery as a promising practical local option and a potential medication‐sparing strategy, particularly ...
Ashley Lebel, Imen Stambouli, Yves Boucher   +2 more
wiley   +1 more source

Effects of Combined Transcranial Direct Current Stimulation and Oral Capsaicinoids on Swallowing Function: A Randomized Controlled Trial

Journal of Oral Rehabilitation, EarlyView.
We investigated the effects of combined transcranial direct current stimulation (tDCS) and oral capsaicinoids on swallowing function in 21 healthy young adults. The combined cortical and peripheral sensory intervention could potentially facilitate swallowing.
Ivy Cheng, Sonja Suntrup‐Krüger
wiley   +1 more source

Efficacy and Safety of Intra‐Articular Therapies for Temporomandibular Disorders: A Systematic Review and Meta‐Analysis

Oral Diseases, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to evaluate the most effective minimally invasive intra‐articular procedure for reducing pain and improving maximum mouth opening (MMO) in individuals diagnosed with painful articular TMD, specifically TMJ osteoarthritis and/or internal derangement.
Mateus Gaya dos Santos, Wellington Luiz de Oliveira da Rosa, Cristian Sbardelotto, Júlia Silva Gomes de Araújo, Camila da Silva Rodrigues, Noéli Boscato   +5 more
wiley   +1 more source

Perceptual Priors Update Contextual Feedback Processing in V1

Topics in Cognitive Science, EarlyView.
Abstract Contextual information and prior knowledge facilitate perceptual processing, improving our recognition of even distorted or obstructed visual inputs. As a result, neuronal processing elicited by identical sensory inputs varies depending on the context in which we encounter those inputs.
Yulia Y. Lazarova, Yingying Huang, Lars F. Muckli, Lucy S. Petro   +3 more
wiley   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Lactate potentiates NMDA receptor currents via an intracellular redox mechanism targeting GluN2B subunits: implications for synaptic plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Astrocyte‐derived lactate enhances neuronal NMDA receptor (NMDAR) function and synaptic plasticity through a redox‐ and CaMKII‐dependent mechanism. Lactate enters neurons via monocarboxylate transporters (MCTs) and is oxidized by lactate dehydrogenase (LDH) to pyruvate, generating NADH and increasing the intracellular NADH/NAD ...
Hubert Fiumelli, Gabriel Herrera‐López, Fouad Lemtiri‐Chlieh, Lorène Mottier, John Girgis, Carine Ben‐Adiba, Pascal Jourdain, Nicolò Carrano, Hanan Mahmood, Amanda Ooi, Stefan T. Arold, Monica Di Luca, Fabrizio Gardoni, Pierre J. Magistretti   +13 more
wiley   +1 more source

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source