Results 281 to 290 of about 197,779 (358)

Could the Polymorphisms of DOCK4 (rs147636134), SYNGAP1 (rs199759879), and FOXP1 (rs767001715) be the Primary Risk Factors for Bipolar Disorder and Autism Spectrum Disorder?

Developmental Neurobiology, Volume 85, Issue 4, October 2025.
Abstract Autism spectrum disorder (ASD) and bipolar disorder (BD) are psychiatric diseases that may overlap in common neurodevelopmental and genetic basis. Forkhead Box P1 (FOXP1), Synaptic Ras GTPase‐activating protein 1 (SYNGAP1), and Dedicator of Cytokinesis 4 (DOCK4) genes are critical for synaptic plasticity, neuronal communication, and brain ...
Elvan Çiftçi, Nimet Sağlam, Tayfun Gözler, İpek Yüksel, Neriman Kilit, İlknur Bozkurt, Muhsin Konuk, Korkut Ulucan, Nevzat Tarhan   +8 more
wiley   +1 more source

Bi-directional allosteric pathway in NMDA receptor activation and modulation. [PDF]

Nat Commun
Bender PA, Chakraborty S, Durham RJ, Berka V, Carrillo E, Jayaraman V.   +5 more
europepmc   +1 more source

Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia

Glia, Volume 73, Issue 10, Page 2025-2034, October 2025.
Main Points Adrenergic signaling through ADRB2 modulates phagocytosis in microglia Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia ADRB2 activation inhibits both P2Y6 function and gene expression ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their ...
Thomas Deluc, Ariel Ase, Marie‐France Dorion, Gilles Maussion, Yeman Tang, Rita T. M. Lo, Irina Shlaifer, Valerio E. Piscopo, Thomas M. Durcan, Stefano Stifani, Philippe Séguéla   +10 more
wiley   +1 more source

Pharmacological target sites for restoration of age-associated deficits in NMDA receptor-mediated norepinephrine release in brain. [PDF]

J Neurochem
Aljohani Y, Payne W, Yasuda RP, Olson T, Kellar KJ, Dezfuli G.   +5 more
europepmc   +1 more source

Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing [PDF]

, 2019
Huettner, James E, Wilding, Timothy J
core   +1 more source

Can Theta Burst Electromagnetic Fields Disrupt Learning in Planaria? Evidence of Impaired Fear‐Conditioned Responses

Bioelectromagnetics, Volume 46, Issue 6, September 2025.
ABSTRACT This study explored the impact of low‐intensity theta burst patterned electromagnetic fields (TBEMF) on fear‐related learning in the flatworm species Planaria, a simple model organism known for its regenerative properties and ability to demonstrate basic learning behaviors. Planaria were exposed to an aversive stimulus (light) in a T‐maze, and
Kassra Ghassemkhani, Blake T. Dotta
wiley   +1 more source

Structure-Activity Relationship of NMDA Receptor Ligands and Their Activities on the ERK Activation through Metabotropic Signaling Pathway. [PDF]

Biomol Ther (Seoul)
Kundu D, Wang M, Paudel S, Wang S, Jang CG, Kim KM.   +5 more
europepmc   +1 more source

Application of the Mass Spectrometry–High‐Throughput Technique Over the Immunohistochemical Analysis for Human Brain Tumor Diagnosis and Prognosis: Insights Into Biomarkers' Identification for the Case Study of Grade IV Astrocytomas and Meningiomas

Biomedical Chromatography, Volume 39, Issue 9, September 2025.
ABSTRACT Human brain tumors were commonly monitored in hospital/clinical laboratories by immunohistochemistry (IHC) technique, which provides major insights into their classification. However, this technique remains laborious and still shows pitfalls. Therefore, the current study was endeavored to reveal the assets of the application of high‐throughput
Kaouthar Louati, Fatma Kolsi, Manel Mellouli, Hanen Louati, Rim Kallel, Rania Zribi, Mahdi Borni, Leila Sellami Hakim, Amina Maalej, Sirine Choura, Mohamed Chamkha, Sami Sayadi, Zouheir Khemakhem, Tahya Sellami Boudawara, Mohamed Zaher Boudawara, Kaouthar Zribi, Fathi Safta   +16 more
wiley   +1 more source

Development and Validation of a Rapid LC–MS/MS Method for Plasma Analysis of Ketamine, Norketamine, Dehydronorketamine, and Hydroxynorketamine

Biomedical Chromatography, Volume 39, Issue 9, September 2025.
ABSTRACT Ketamine, a well‐established dissociative anesthetic, has recently gained significant attention for its rapid‐acting antidepressant effects, particularly in treatment‐resistant depression. In this study, we developed and validated a state‐of‐the‐art liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the bioanalysis of ...
Jan Thomann, Selina Kraus, Livio Erne, Severin B. Vogt, Matthias E. Liechti, Dino Luethi   +5 more
wiley   +1 more source

Advances in the Treatment of Cognitive Impairment in Schizophrenia: Targeting NMDA Receptor Pathways. [PDF]

Int J Mol Sci
Zhang T, Liu C, Zhong N, Wang Y, Huang Y, Zhang X.   +5 more
europepmc   +1 more source