Results 281 to 290 of about 186,082 (377)

Membrane trafficking of synaptic adhesion molecules

The Journal of Physiology, EarlyView.
Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley   +1 more source

Activation of TRPA1 and TRPM3 triggers Ca2+ waves in central terminals of sensory neurons and facilitates synaptic activity in the spinal dorsal horn

The Journal of Physiology, EarlyView.
Abstract figure legend Transient receptor potential ankyrin 1 (TRPA1) and melastatin 3 (TRPM3) activation regulate pre‐ and postsynaptic Ca2+ concentrations and synaptic activity in the dorsal horn of the spinal cord. Left: a model that describes how activation of TRPA1 and TRPM3 channels induces an influx of Ca2+ in the central terminals of sensory ...
Yaroslav E. Andrianov, Alex L. Keyes, Charles A. Warwick, Miriam C. McDonough, Leonid P. Shutov, Kavita S. Solanki, Jon M. Resch, Alexander G. Bassuk, Nana Voitenko, Pavel Belan, Yuriy M. Usachev   +10 more
wiley   +1 more source

Intersectin‐1 enhances calcium‐dependent replenishment of the readily releasable pool of synaptic vesicles during development

The Journal of Physiology, EarlyView.
Abstract figure legend During development, Intersectin‐1 (Itsn1) translocates near voltage‐gated calcium channels (VGCCs) to enhance Ca2+‐dependent replenishment of readily releasable synaptic vesicles (SVs). In the presynaptic terminal, SVs undergo a cycle involving formation (step 1), docking (step 2), exocytosis (step 3), endocytosis (step 4) and ...
Yi‐Mei Yang, Adam Fekete, Jason Arsenault, Ameet S. Sengar, Jamila Aitoubah, Giovanbattista Grande, Angela Li, Eric W. Salter, Alex Wang, Melanie D. Mark, Stefan Herlitze, Sean E. Egan, Michael W. Salter, Lu‐Yang Wang   +13 more
wiley   +1 more source

Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins

The Journal of Physiology, EarlyView.
Abstract figure legend Figure depicts the key finding from this study. While loss of all dynamins severely debilitates synaptic vesicle retrieval following repetitive activity, retrieval and recycling of individual synaptic vesicles following spontaneous fusion or sparse stimulation are minimally affected.
Olusoji A. T. Afuwape, Natali L. Chanaday, Merve Kasap, Lisa M. Monteggia, Ege T. Kavalali   +4 more
wiley   +1 more source

Catatonia in anti-NMDA receptor encephalitis: a case series and approach to improve outcomes with electroconvulsive therapy. [PDF]

BMJ Neurol Open
Kraiter FG, May DT, Slauer RD, Abburi N, Eckstein C, Shah S, Komisar JR, Feigal JP.   +7 more
europepmc   +1 more source

GluN2C/D‐containing NMDA receptors enhance temporal summation and increase sound‐evoked and spontaneous firing in the inferior colliculus

The Journal of Physiology, EarlyView.
Abstract figure legend Here, we find that GluN2D‐containing NMDA receptors (NMDARs) are expressed by most vasoactive intestinal peptide neurons in the inferior colliculus (IC). These receptors are less susceptible to Mg2+ blockade compared to GluN2A/B‐containing NMDARs, allowing ions to flow at resting membrane potential.
Audrey C. Drotos, Rachel L. Zarb, Victoria Booth, Michael T. Roberts   +3 more
wiley   +1 more source

NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. [PDF]

Brain
Jamet Z, Mergaux C, Meras M, Bouchet D, Villega F, Kreye J, Prüss H, Groc L.   +7 more
europepmc   +1 more source

The effect of M‐current activation on controller gain and obstructive sleep apnoea severity: a randomised controlled trial using flupirtine

The Journal of Physiology, EarlyView.
Abstract figure legend Investigating the effect of flupirtine, a KCNQ channel opener, on ventilatory control instability (i.e. loop gain) and obstructive sleep apnoea (OSA) severity. Left panel: high loop gain has been shown to contribute to airway collapse in patients with OSA.
Luke D. J. Thomson, Shane A. Landry, Andre Arellano, Jinny Collet, Stuart Huddle, Denise M. O'Driscoll, Dwayne L. Mann, Caroline Beatty, Simon A. Joosten, Garun S. Hamilton, Phillip J. Berger, Ian Cooke, Bradley A. Edwards   +12 more
wiley   +1 more source

Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis. [PDF]

Nat Struct Mol Biol
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S.   +15 more
europepmc   +1 more source

Memantine Exacerbates Trimethyltin‐Induced Neurodegeneration and Delays Cognitive Impairment Recovery

Neuropsychopharmacology Reports, Volume 45, Issue 2, June 2025.
Trimethyltin (TMT) induces transient neuronal loss and cognitive impairments, serving as a model for transient brain damage. This study investigated the effects of early memantine (MEM) treatment on TMT‐induced brain injury. Memantine worsened TMT‐induced cognitive impairment and neuronal degeneration in the hippocampus, suggesting that early MEM ...
Yusuke Onaka, Taro Yamaguchi, Takumu Yamasaki, Koki Morishige, Masanori Yoneyama   +4 more
wiley   +1 more source