Results 311 to 320 of about 203,682 (360)
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General Pharmacology: The Vascular System, 1993
1. Beginning with electrophysiological evidence for two populations of receptors for N-methyl-D-aspartate (NMDA) which did or did not respond to the agonist quinolinic acid, evidence has grown for such subdivision. 2. Data from binding studies is consistent with differences between three NMDA receptors in the striatum, thalamus and cerebellum with ...
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1. Beginning with electrophysiological evidence for two populations of receptors for N-methyl-D-aspartate (NMDA) which did or did not respond to the agonist quinolinic acid, evidence has grown for such subdivision. 2. Data from binding studies is consistent with differences between three NMDA receptors in the striatum, thalamus and cerebellum with ...
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Fundamental & Clinical Pharmacology, 1993
Summary— The synaptic responses elicited by glutamate and aspartate in the CNS are mediated by distinct groups of receptors which include the ionotropic NMDA receptor. The NMDA receptor is activated by high‐strength synaptic input and produces relatively sustained depolarization which can lead to repetitive burst firing.
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Summary— The synaptic responses elicited by glutamate and aspartate in the CNS are mediated by distinct groups of receptors which include the ionotropic NMDA receptor. The NMDA receptor is activated by high‐strength synaptic input and produces relatively sustained depolarization which can lead to repetitive burst firing.
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1990
Brief periods of anoxia cause a marked, but apparently fully reversible interruption of integrated brain function, whose cellular mechanism is not yet fully understood. For some 50 years it has been known that the hippocampus is one of the first brain regions to be affected by anoxia (Sugar and Gerard 1937).
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Brief periods of anoxia cause a marked, but apparently fully reversible interruption of integrated brain function, whose cellular mechanism is not yet fully understood. For some 50 years it has been known that the hippocampus is one of the first brain regions to be affected by anoxia (Sugar and Gerard 1937).
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2003
Abstract Alcohol dependence (“alcoholism”) is diagnosed based in part on the development of physiological adaptations to alcohol (ethanol) including tolerance and dependence, and loss of control over alcohol intake. It is believed that alcohol is initially ingested for its reinforcing effects (positive or negative), and that adaptive changes in the ...
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Abstract Alcohol dependence (“alcoholism”) is diagnosed based in part on the development of physiological adaptations to alcohol (ethanol) including tolerance and dependence, and loss of control over alcohol intake. It is believed that alcohol is initially ingested for its reinforcing effects (positive or negative), and that adaptive changes in the ...
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NMDA Receptors as Voltage Sensors
2017The membrane potential is an essential parameter of a living cell. However, measurements of the membrane potential using conventional techniques are associated with a number of artifacts. Cell-attached recordings of the currents through NMDA receptor channels enable noninvasive measurements of the neuronal membrane potential.
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NAAG, NMDA Receptor and Psychosis
Current Medicinal Chemistry, 2012At central synapses, glutamate is the main excitatory neurotransmitter. Once released from presynaptic terminals, glutamate activates a number of different glutamatergic receptors one of which is the ligand gated ionophore glutamatergic subtype N-methyl-D-aspartate receptors (NMDARs).
Richard, Bergeron, Joseph T, Coyle
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Redox modulation of the NMDA receptor
Cellular and Molecular Life Sciences CMLS, 2000Redox modulation has been recognized to be an important mechanism of regulation for the N-methyl-D-aspartate (NMDA) receptor. Sulfhydryl reducing agents enhance, whereas oxidizing agents decrease, NMDA-evoked currents. Multiple cysteine residues located in different NMDA receptor subunits have been identified as molecular determinants underlying redox ...
Y B, Choi, S A, Lipton
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Modal gating of NMDA receptors
Trends in Neurosciences, 2004The decay time course of excitatory postsynaptic currents generated by slow glutamatergic synapses is determined by the single-channel kinetics of postsynaptic NMDA receptor channels. In a recent study, examination of these single-channel kinetics has revealed that NMDA receptors can enter into modal gating.
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