Results 321 to 330 of about 197,779 (358)

Excitotoxity and the NMDA receptor

Trends in Neurosciences, 1987
Abstract The same receptors for excitatory amino acids (EAA) that mediate direct neuronal depolarization can also be responsible for neuronal injury. Prolonged stimulation of EAA receptors of either the N-methyl-d-aspartate (NMDA) or non-NMDA types eventually results in the death of most central neurons.
John W. Olney, Steven M. Rothman
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NMDA RECEPTORS IN ALCOHOLISM

2003
Abstract Alcohol dependence (“alcoholism”) is diagnosed based in part on the development of physiological adaptations to alcohol (ethanol) including tolerance and dependence, and loss of control over alcohol intake. It is believed that alcohol is initially ingested for its reinforcing effects (positive or negative), and that adaptive changes in the ...
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NMDA receptors in invertebrates

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1992
The concept of an NMDA receptor has evolved over some thirty years. The initial impetus was the need to better distinguish “glutamate preferring” from “aspartate preferring” receptors among neurons of the mammalian spinal cord (Curtis and Watkins, 1963; McCulloch et al., 1974). This search gave rise to substantial evidence for a diversity of ionotropic
Raymon M. Glantz, Cindy Pfeiffer-Linn
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NAAG, NMDA Receptor and Psychosis

Current Medicinal Chemistry, 2012
At central synapses, glutamate is the main excitatory neurotransmitter. Once released from presynaptic terminals, glutamate activates a number of different glutamatergic receptors one of which is the ligand gated ionophore glutamatergic subtype N-methyl-D-aspartate receptors (NMDARs).
Richard Bergeron, Joseph T. Coyle
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NMDA Receptor Antagonists

2019
NMDA receptor antagonists have a number of indications in chronic and acute pain. While ketamine represents the most frequently utilized analgesic from this group, other agents possess similar properties. The use of ketamine has been associated with significantly improved perioperative and chronic pain relief and decreased opioid requirements.
Carrie A. Schroeder, Kristopher M. Schroeder   +1 more
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Regulation of NMDA receptors by ethanol

2000
NMDA receptors are glutamate-gated ion channels, mediating excitatory neurotransmission in the brain. These widely distributed receptors are known to play a role in neuronal development and synaptic plasticity, but over stimulation of these receptors can lead to neurotoxicity.
Maharaj K. Ticku, Meena Kumari
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The NMDA receptor

Neuroscience, 1991
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Immunocytochemistry of NMDA Receptors [PDF]

, 2003
Ronald S. Petralia, Robert J. Wenthold
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Overview of the NMDA Receptor

2017
The N-methyl-d-aspartate receptor (NMDAR) is a glutamate-gated ion channel that is critically involved in physiological and pathological functions in the central nervous system (CNS). Over the last 25 years, molecular biological studies revealed the molecular diversity of NMDAR subunits, the structural basis of NMDAR functions, and the in vivo ...
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NMDA Receptor Protocols

1999
Isolation of Receptor Clones by Expression Screening in Xenopus Oocytes, Fumio Nakamura, Yoshio Goshima, Stephem M. Struttmatter, and Susumu Kawamoto. Expression of NMDA Receptor Channel Subunit Proteins using Baculovirus and Herpesvirus Vectors, Susumu Kawamoto, Satoshi Hattori, Shigeo Uchino Masayoshi Mishina, and Kenji Okuda. Transient Expression of
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