Results 341 to 350 of about 186,082 (377)

NMDA receptors in invertebrates

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1992
The concept of an NMDA receptor has evolved over some thirty years. The initial impetus was the need to better distinguish “glutamate preferring” from “aspartate preferring” receptors among neurons of the mammalian spinal cord (Curtis and Watkins, 1963; McCulloch et al., 1974). This search gave rise to substantial evidence for a diversity of ionotropic
Raymon M. Glantz, Cindy Pfeiffer-Linn
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NMDA RECEPTORS IN ALCOHOLISM

2003
Abstract Alcohol dependence (“alcoholism”) is diagnosed based in part on the development of physiological adaptations to alcohol (ethanol) including tolerance and dependence, and loss of control over alcohol intake. It is believed that alcohol is initially ingested for its reinforcing effects (positive or negative), and that adaptive changes in the ...
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NAAG, NMDA Receptor and Psychosis

Current Medicinal Chemistry, 2012
At central synapses, glutamate is the main excitatory neurotransmitter. Once released from presynaptic terminals, glutamate activates a number of different glutamatergic receptors one of which is the ligand gated ionophore glutamatergic subtype N-methyl-D-aspartate receptors (NMDARs).
Richard Bergeron, Joseph T. Coyle
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NMDA Receptor Antagonists

2019
NMDA receptor antagonists have a number of indications in chronic and acute pain. While ketamine represents the most frequently utilized analgesic from this group, other agents possess similar properties. The use of ketamine has been associated with significantly improved perioperative and chronic pain relief and decreased opioid requirements.
Carrie A. Schroeder, Kristopher M. Schroeder   +1 more
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Basic Pharmacology of NMDA Receptors

Current Pharmaceutical Design, 2012
NMDA receptors are ionotropic receptors mediating glutamatergic neurotransmission and play a role in several basic functions in the central nervous system, from regulating neurodevelopment and synaptic plasticity, learning and memory formation, cognitive processes, rhythm generation necessary for locomotor activity and breathing, and excitotoxicity ...
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NMDA receptors expressed in oligodendrocytes

BioEssays, 2006
Oligodendrocytes are known to express (Ca2+)-permeable glutamate receptors and to have low resistance to oxidative stress, two factors that make them potentially susceptible to injury. Oligodendrocyte injury is intrinsic to the loss of function experienced in conditions ranging from cerebral palsy to spinal cord injury, focal ischaemia and multiple ...
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Immunocytochemistry of NMDA Receptors [PDF]

, 2003
Ronald S. Petralia, Robert J. Wenthold
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Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Overview of the NMDA Receptor

2017
The N-methyl-d-aspartate receptor (NMDAR) is a glutamate-gated ion channel that is critically involved in physiological and pathological functions in the central nervous system (CNS). Over the last 25 years, molecular biological studies revealed the molecular diversity of NMDAR subunits, the structural basis of NMDAR functions, and the in vivo ...
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The NMDA receptor

Journal of Epilepsy, 1991
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