Results 11 to 20 of about 1,434,331 (312)
Binding hotspots of BAZ2B bromodomain:histone interaction revealed by solution NMR driven docking [PDF]
, 2014 Bromodomains are epigenetic reader domains, which have come under increasing scrutiny both from academic and pharmaceutical research groups. Effective targeting of the BAZ2B bromodomain by small molecule inhibitors has been recently reported, but no ...
Ferguson, Fleur M. +26 more
core +1 more source
Frontiers in Molecular Neuroscience, 2017 Alzheimer’s disease (AD) is an age-related neurodegenerative disorder, characterized by progressive loss of cognitive functions and memory. Excessive intake of aluminum chloride in drinking water is associated with amyloid plaques and neurofibrillary ...
Kamal Saba +6 more
doaj +1 more source
A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V
Nature Communications, 2022 Constriction of the selectivity filter is assumed to be a hallmark of C-type inactivation in K+ channels. Using different high-resolution methods, this study shows a distinct C-type inactivation mechanism in a KcsA mutant that emulates Kv-channels.
Ahmed Rohaim +8 more
doaj +1 more source
Formation of the β-barrel assembly machinery complex in lipid bilayers as seen by solid-state NMR
Nature Communications, 2018 The β-barrel assembly machinery (BAM) catalyzes β-barrel protein insertion into the outer membrane of E.coli. Here authors employ high-sensitivity solid-state NMR to reveal how the lipid environment and formation of the BamA-BamCDE complex affect BamA ...
Cecilia Pinto +5 more
doaj +1 more source
Membranes, 2015 Phosphatidylinositol 3-kinase-related kinases (PIKKs) play vital roles in the regulation of cell growth, proliferation, survival, and consequently metabolism, as well as in the cellular response to stresses such as ionizing radiation or redox changes. In
Maristella De Cicco +2 more
doaj +1 more source
Nature Communications, 2019 Processing bodies are membrane less organelles that contain enzymes involved in mRNA turnover, among them enhancer of decapping 3 (Edc3). Here the authors use solid- and solution-state NMR spectroscopy to characterize the structural organization and ...
Reinier Damman +5 more
doaj +1 more source
The Cell Surface, 2020 Cell walls are essential in the interaction of fungi with the (a)biotic environment and are also key to hyphal morphogenesis and mechanical strength. Here, we used solid-state NMR (ssNMR) spectroscopy combined with HPLC and GC–MS to study the structural ...
Helena Leona Ehren +5 more
doaj +1 more source
NMR spectroscopy of nystose [PDF]
Carbohydrate Research, 1993 Sucrose (11, 1-kestose (21, and nystose (3) are the smallest inulin-related oligosaccharides1T2, which consist of (2 -+ l)-linked /3-D-fructofuranosyl residues, terminated by an a-D-glucopyranosyl unit in a (1 + 2) linkage. Several ‘H and 13C NMR assignments and some J,,, and J,,, values for inulin and inulin-related oligosaccharides have been ...
Vliegenthart, J.F.G. +4 more
openaire +3 more sources
Probing Nuclear Dipole Moments and Magnetic Shielding Constants through 3-Helium NMR Spectroscopy
Physchem, 2022 Multinuclear NMR studies of the gaseous mixtures that involve volatile compounds and 3He atoms are featured in this review. The precise analyses of 3He and other nuclei resonance frequencies show linear dependencies on gas density.
Włodzimierz Makulski
doaj +1 more source