Results 21 to 30 of about 190,531 (261)
Shifts in the selectivity filter dynamics cause modal gating in K+ channels
Nature Communications, 2019 Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels
Shehrazade Jekhmane +7 more
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Biological solid-state NMR: Integrative across different scientific disciplines
Journal of Structural Biology: X, 2022 For almost five decades, solid-state NMR (ssNMR) has been used to study complex biomolecular systems. This article gives a view on how ssNMR methods and applications have evolved during this time period in a broader structural biology context.
Marc Baldus
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Mode of action of teixobactins in cellular membranes
Nature Communications, 2020 The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind ...
Rhythm Shukla +14 more
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A Simple Method for the Preparation of 2,4,6-trichloroborazine and Evaluation of 1H-NMR Spectra [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2022 The compound 2,3,6-trichloroborazine (TCB) is known as a valuable precursor to prepare boron nitride and various derivatives of borazine. Difficulties in the preparation of TCB via conventional methods on the one hand, and its importance for material ...
Aria Norozi +2 more
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Binding of micro-nutrients to the cell wall of the fungus Schizophyllum commune
The Cell Surface, 2023 The cell wall fulfils several functions in the biology of fungi. For instance, it provides mechanical strength, interacts with the (a)biotic environment, and acts as a molecular sieve.
Fleur E.L. Kleijburg +3 more
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Pharmaceutics, 2021 At present, the risk of generic substitutions in warfarin tablets is still being discussed. The aim of this study was to assess whether API interactions with commonly used excipients may affect the safety of generic replacement of warfarin sodium tablets.
Jan Muselík +9 more
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NeurogliaElectroconvulsive therapy (ECT) is an effective treatment for severe and drug-resistant depression, yet its mode of action remains poorly understood.
Ajay Sarawagi +5 more
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A comprehensive framework of E2–RING E3 interactions of the human ubiquitin–proteasome system
Molecular Systems Biology, 2009 Covalent attachment of ubiquitin to substrates is crucial to protein degradation, transcription regulation and cell signalling. Highly specific interactions between ubiquitin‐conjugating enzymes (E2) and ubiquitin protein E3 ligases fulfil essential ...
Sjoerd J L van Wijk +6 more
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High-resolution NMR studies of antibiotics in cellular membranes
Nature Communications, 2018 Antibiotics that target the peptidoglycan precursor lipid II are promising templates for next-generation antibiotics. Here authors use solid-state NMR and monitor lipid II-binding antibiotics, such as nisin, directly in cell membranes.
João Medeiros-Silva +7 more
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NMR Spectroscopy for Metabolomics Research [PDF]
Metabolites, 2019 Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the three principal analytical techniques used in metabolomics (the other two being gas chromatography coupled to mass spectrometry (GC-MS) and liquid chromatography coupled with single-stage mass spectrometry (LC-MS)). The relative ease of sample preparation, the ability
Abdul-Hamid Emwas +10 more
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