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Protein NMR spectroscopy [PDF]
Current Biology, 1998 Protein NMR spectroscopy does have its limitations. It has so far been used mainly for small proteins with molecular weight of less than 30 kDa, although a handful of publications have now reported the NMR study of proteins up to 40–50 kDa. Larger proteins typically have faster relaxation rates, which results in fatter NMR peaks that tend to merge with
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Shifts in the selectivity filter dynamics cause modal gating in K+ channels
Nature Communications, 2019 Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels
Shehrazade Jekhmane +7 more
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Biological solid-state NMR: Integrative across different scientific disciplines
Journal of Structural Biology: X, 2022 For almost five decades, solid-state NMR (ssNMR) has been used to study complex biomolecular systems. This article gives a view on how ssNMR methods and applications have evolved during this time period in a broader structural biology context.
Marc Baldus
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Ultrahigh‐Resolution NMR Spectroscopy [PDF]
Angewandte Chemie International Edition, 2014 All psyched up: A flexible and general pure shift experiment (PSYCHE) has been developed that offers superior sensitivity, spectral purity, and tolerance of strong coupling over existing methods for broadband homonuclear decoupling. The partial spectra of estradiol in [D6]DMSO obtained by normal 1H NMR spectroscopy and PSYCHE are shown for comparison.
Foroozandeh, Mohammadali +5 more
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Nuclear magnetic resonance (NMR) applied to membrane-protein complexes [PDF]
, 2016 Increasing evidence suggests that most proteins occur and function in complexes rather than as isolated entities when embedded in cellular membranes.
Baldus, Marc +5 more
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Mode of action of teixobactins in cellular membranes
Nature Communications, 2020 The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind ...
Rhythm Shukla +14 more
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A Simple Method for the Preparation of 2,4,6-trichloroborazine and Evaluation of 1H-NMR Spectra [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2022 The compound 2,3,6-trichloroborazine (TCB) is known as a valuable precursor to prepare boron nitride and various derivatives of borazine. Difficulties in the preparation of TCB via conventional methods on the one hand, and its importance for material ...
Aria Norozi +2 more
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Binding of micro-nutrients to the cell wall of the fungus Schizophyllum commune
The Cell Surface, 2023 The cell wall fulfils several functions in the biology of fungi. For instance, it provides mechanical strength, interacts with the (a)biotic environment, and acts as a molecular sieve.
Fleur E.L. Kleijburg +3 more
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Pharmaceutics, 2021 At present, the risk of generic substitutions in warfarin tablets is still being discussed. The aim of this study was to assess whether API interactions with commonly used excipients may affect the safety of generic replacement of warfarin sodium tablets.
Jan Muselík +9 more
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Kinetic Analysis of Protein Aggregation Monitored by Real-Time 2D Solid-State NMR Spectroscopy [PDF]
, 2011 It is shown that real-time 2D solid-state NMR can be used to obtain kinetic and structural information about the process of protein aggregation. In addition to the incorporation of kinetic information involving intermediate states, this approach can ...
Baldus, Marc +11 more
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