Results 41 to 50 of about 406,460 (331)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Brevibacillin 2V, a Novel Antimicrobial Lipopeptide With an Exceptionally Low Hemolytic Activity

Frontiers in Microbiology, 2021
Bacterial non-ribosomally produced peptides (NRPs) form a rich source of antibiotics, including more than 20 of these antibiotics that are used in the clinic, such as penicillin G, colistin, vancomycin, and chloramphenicol.
Xinghong Zhao, Xiaoqi Wang, Rhythm Shukla, Rhythm Shukla, Raj Kumar, Markus Weingarth, Eefjan Breukink, Oscar P. Kuipers   +7 more
doaj   +1 more source

Neutral and Cationic Rare Earth Metal Alkyl and Benzyl Compounds with the 1,4,6-Trimethyl-6-pyrrolidin-1-yl-1,4-diazepane Ligand and Their Performance in the Catalytic Hydroamination/Cyclization of Aminoalkenes [PDF]

, 2008
A new neutral tridentate 1,4,6-trimethyl-6-pyrrolidin-1-yl-1,4-diazepane (L) was prepared. Reacting L with trialkyls M(CH2SiMe3)3(THF)2 (M = Sc, Y) and tribenzyls M(CH2Ph)3(THF)3 (M = Sc, La) yielded trialkyl complexes (L)M(CH2SiMe3)3 (M = Sc, 1; M = Y ...
Arndt S., Arndt S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Bambirra S., Booij M., Carver C. T., De Kimpe N., Douglass M. R., Douglass M. R., Evans W. J., Gagné M. R., Gagné M. R., Gao W., Ge S, Ge S., Ge S., Ge S., Giardello M. A., Gribkov D. V., Hajela S., Hayes P. G., Hong S, Horino Y., Howe R. G., Kawaoka A. M., Kim J. Y., Komeyama K., Lappert M. F., Lauterwasser F., Lawrence S. C., Li W., Liu Y., Lukesova L., Lukesova L., Meyer N., Meyer N., Molander G. A., Molander G. A., Nishiura M., Robert D., Ryu J. -S, Sakakura Y., Shannon R. D., Stubbert B. D., Tardif O., Tazelaar C. G. J., Tokuda M., Tredget C. S., Trifonov A. A, Wang Q., Ward B. D., Yu P. F., Yuen H. F., Zeimentz P. M., Zhang L.   +60 more
core   +3 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Brevibacillin 2V Exerts Its Bactericidal Activity via Binding to Lipid II and Permeabilizing Cellular Membranes

Frontiers in Microbiology, 2021
Lipo-tridecapeptides, a class of bacterial non-ribosomally produced peptides, show strong antimicrobial activity against Gram-positive pathogens, including antibiotic-resistant Staphylococcus aureus and Enterococcus spp.
Xinghong Zhao, Xiaoqi Wang, Rhythm Shukla, Rhythm Shukla, Raj Kumar, Markus Weingarth, Eefjan Breukink, Oscar P. Kuipers   +7 more
doaj   +1 more source

The Solid State \u3csup\u3e13\u3c/sup\u3eC-NMR Spectra of Some Carbides [PDF]

, 1978
The utility of NMR spectroscopy to the study of liquids or solids dissolved in liquids is well known. This technique has been used infrequently to studies in the solid state[I,2]. Work has been done on diamond, graphite and coa113-6].
Haworth, Daniel T., Wilkie, Charles A.
core   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Detection of Metabolites by Proton Ex Vivo NMR, in Vivo MR Spectroscopy Peaks and Tissue Content Analysis: Biochemical-Magnetic Resonance Correlation: Preliminary Results [PDF]

, 2009
*Aim*: Metabolite concentrations by in vivo magnetic resonance spectroscopy and ex vivo NMR spectroscopy were compared with excised normal human tissue relaxation times and tissue homogenate contents. *Hypothesis*: Biochemical analysis
Arun Agrawala, Madan Rehani, Rakesh Sharma   +2 more
core   +1 more source

Relative Reactivity of the Metal-Amido versus Metal-Imido Bond in Linked Cp-Amido and Half-Sandwich Complexes of Vanadium [PDF]

, 2008
Treatment of (η5-C5H4C2H4NR)V(N-t-Bu)Me (R = Me, i-Pr) and CpV(N-p-Tol)(N-i-Pr2)Me (Cp = η5-C5H5) with B(C6F5)3 or [Ph3C][B(C6F5)4] results in formation of the corresponding cations, [(η5-C5H4C2H4NR)V(N-t-Bu)]+ and [CpV(N-p-Tol)(N-i-Pr2)]+.
Alonso F., Anderson L. L., Anderson L. L., Bouwkamp M. W., Bytschkov I., Carpentier J.-F., Doye S., Frisch M. J., Gagné M. R., Gagné M. R., Horton A. D., Hughes A. K., Johnson J. S., Li Y., Lorber C., Margl P., Mayer J. M., Müller T. E., Nobis M., Odom A. L., Pohlki F., Pohlki F., Preuss F., Preuss F., Sinnema P. J., Straub B. F., Stubbert B. D., Vanka K., Vatamanu M., Witte P. T., Wu F., Yamada J.   +31 more
core   +5 more sources