Results 41 to 50 of about 887,442 (314)

Sequential Diffusion Spectra as a Tool for Studying Time-Dependent Translational Molecular Dynamics: A Cement Hydration Study

Molecules, 2019
The translational molecular dynamics in porous materials are affected by the presence of the porous structure that presents an obstacle for diffusing molecules in longer time scales, but not as much in shorter time scales.
Igor Serša
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Recent developments in solid-state NMR spectroscopy of crystalline microporous materials [PDF]

, 2014
Microporous materials, having pores and channels on the same size scale as small to medium molecules, have found many important applications in current technologies, including catalysis, gas separation and drug storage and delivery.
Ashbrook, Sharon E., Dawson, Daniel M., Seymour, Valerie R., Dawson, Daniel M.; id_orcid, Ashbrook, Sharon E.; id_orcid   +4 more
core   +1 more source

Bromination of endo-7-norbornene derivatives revisited: failure of a computational NMR method in elucidating the configuration of an organic structure

Beilstein Journal of Organic Chemistry, 2023
Previously we reported on the bromination of endo-7-bromonorbornene at different temperatures yielding mixtures of addition products. The structural elucidations of the formed compounds were achieved by NMR spectroscopy. Particularly, the γ-gauche effect
Demet Demirci Gültekin, Arif Daştan, Yavuz Taşkesenligil, Cavit Kazaz, Yunus Zorlu, Metin Balci   +5 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

NMR and MD studies of the temperature-dependent dynamics of RNA YNMG-tetraloops [PDF]

, 2008
In a combined NMR/MD study, the temperature-dependent changes in the conformation of two members of the RNA YNMG-tetraloop motif (cUUCGg and uCACGg) have been investigated at temperatures of 298, 317 and 325 K. The two members have considerable different
Stock, Gerhard, Wöhnert, Jens, Villa, Alessandra, Widjajakusuma, Elisabeth, Schwalbe, Harald (Prof. Dr.), Ferner, Jan, Duchardt-Ferner, Elke   +6 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Molecular action of NZ2114, a superior plectasin derivative

npj Antimicrobials and Resistance
NZ2114 is a triple-mutant of the natural peptide antibiotic plectasin that targets the peptidoglycan precursor molecule Lipid II using a supramolecular action, involving assembly of plectasin-Lipid II complexes in a large oligomeric structure, that is ...
Maik G. N. Derks, Shehrazade Jekhmane, Sourav Maity, Vicky Charitou, Cornelis J. Slingerland, Benjamin Vermeer, Mick van der Weijde, Charalampos Ntallis, Nathaniel I. Martin, Wouter H. Roos, Eefjan Breukink, Markus Weingarth   +11 more
doaj   +1 more source

“Pure by NMR”?

Organic Letters, 2008
Integration of a (13)C-(1)H satellite peak of a given (12)C-(1)H parent resonance within a quantitative (1)H NMR spectrum and comparison to the minor component represents a simple protocol for the accurate determination of diastereoisomeric ratios of up to 1000:1 (i.e., 99.8% de).
Claridge, T, Davies, S, Polywka, M, Roberts, P, Russell, A, Savory, E, Smith, A   +6 more
openaire   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source