Results 31 to 40 of about 858,950 (318)
Analysis of the interface variability in NMR structure ensembles of protein-protein complexes [PDF]
, 2016 NMR structures consist in ensembles of conformers, all satisfying the experimental restraints, which exhibit a certain degree of structural variability.
NMR Spectroscopy +6 more
core +2 more sources
Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
Mycobiology, 2021 In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture ...
Ji-Yul Kim +6 more
doaj +1 more source
A new structural arrangement in proteins involving lysine NH3 + group and carbonyl
Scientific Reports, 2017 Screening of the Protein Data Bank led to identification of a recurring structural motif where lysine NH3 + group interacts with backbone carbonyl. This interaction is characterized by linear atom arrangement, with carbonyl O atom positioned on the three-
Olga N. Rogacheva +3 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
NMR characterization of foldedness for the production of E3 RING domains [PDF]
, 2010 We summarize the use of NMR spectroscopy in the production and the screening of stability and foldedness of protein domains, and apply it to the RING domains of E3 ubiquitin-ligases.
NMR Spectroscopy +6 more
core +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Solid-state NMR on larger biomolecules [PDF]
, 2011 In the last years, remarkable progress has been made to probe molecular structure of biological systems using Magic Angle Spinning solid-state NMR (ssNMR). Prominent examples relate to research areas that have remained challenging to classical structural
NMR Spectroscopy +2 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Metabolomics Reveals Discrimination of Iranian Propolis Using LC-MS and NMR Analysis [PDF]
Iranian Journal of Chemistry & Chemical EngineeringPropolis is a multifaceted substance that bees produce using nectar from flowers, buds, tree gums, and resins found in plant stems, branches, and leaves.
Masoomeh Sharbatdaran +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source