Results 31 to 40 of about 755,525 (317)

A new structural arrangement in proteins involving lysine NH3 + group and carbonyl

Scientific Reports, 2017
Screening of the Protein Data Bank led to identification of a recurring structural motif where lysine NH3 + group interacts with backbone carbonyl. This interaction is characterized by linear atom arrangement, with carbonyl O atom positioned on the three-
Olga N. Rogacheva, Sergei A. Izmailov, Lyudmila V. Slipchenko, Nikolai R. Skrynnikov   +3 more
doaj   +1 more source

Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors

Mycobiology, 2021
In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture ...
Ji-Yul Kim, Dae-Won Ki, Yoon-Ju Lee, Lee Su Ha, E-Eum Woo, In-Kyoung Lee, Bong-Sik Yun   +6 more
doaj   +1 more source

Analysis of the interface variability in NMR structure ensembles of protein-protein complexes [PDF]

, 2016
NMR structures consist in ensembles of conformers, all satisfying the experimental restraints, which exhibit a certain degree of structural variability.
NMR Spectroscopy, CALVANESE, LUISA, Sub NMR Spectroscopy, Vangone, Anna, Oliva, Romina, D'AURIA, GABRIELLA, FALCIGNO, LUCIA   +6 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

NMR characterization of foldedness for the production of E3 RING domains [PDF]

, 2010
We summarize the use of NMR spectroscopy in the production and the screening of stability and foldedness of protein domains, and apply it to the RING domains of E3 ubiquitin-ligases.
NMR Spectroscopy, Folkers, G.E., Huang, A., Sub NMR Spectroscopy, Boelens, R., Dep Scheikunde, de Jong, R.N.   +6 more
core   +1 more source

Metabolomics Reveals Discrimination of Iranian Propolis Using LC-MS and NMR Analysis [PDF]

Iranian Journal of Chemistry & Chemical Engineering
Propolis is a multifaceted substance that bees produce using nectar from flowers, buds, tree gums, and resins found in plant stems, branches, and leaves.
Masoomeh Sharbatdaran, Mohammad Rezaee, Marzieh Heidarieh, Samira Shahbazi   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Solid-state NMR on larger biomolecules [PDF]

, 2011
In the last years, remarkable progress has been made to probe molecular structure of biological systems using Magic Angle Spinning solid-state NMR (ssNMR). Prominent examples relate to research areas that have remained challenging to classical structural
NMR Spectroscopy, Baldus, M., Sub NMR Spectroscopy   +2 more
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source