Results 121 to 130 of about 2,900 (147)
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NNMT Reduces Cellular Methylation Potential
Cancer Discovery, 2013Abstract Nicotinamide N-methyltransferase (NNMT) expression induces widespread protein hypomethylation.
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Exploring NNMT: from metabolic pathways to therapeutic targets
Archives of Pharmacal ResearchCellular metabolism-related epigenetic modulation plays a pivotal role in the maintenance of cellular homeostasis. Nicotinamide N-methyltransferase (NNMT) serves as a crucial link between cellular metabolism and epigenetics by catalyzing nicotinamide methylation using the universal methyl donor S-adenosyl-L-methionine.
Jeongwoo, Park +6 more
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Nicotinamide N-Methyltransferase (NNMT): A Key Enzyme in Cancer Metabolism and Therapeutic Target
International ImmunopharmacologyEmerging research has positioned Nicotinamide N-methyltransferase (NNMT) as a key player in oncology, with its heightened expression frequently observed across diverse cancers. This increased presence is tightly linked to tumor initiation, proliferation, and metastasis. The enzymatic function of NNMT is centered on the methylation of nicotinamide (NAM),
Jiang-Hua Li, Wei-Dong Sun, Ya-Zhong Mei
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NNMT Enhances Invasive and Migratory Capacity of Keloid Fibroblasts and M2 Macrophage Polarization
Archives of Biochemistry and BiophysicsKeloid are characterized by fibroblastic proliferation and excessive collagen deposition. Nicotinamide N-methyltransferase (NNMT) belongs to the methyltransferase family and plays an important role in various physiological processes, including keloid formation. However, the role of NNMT in keloid development remains poorly understood. In this study, we
Ximei Wang
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Role of NNMT and NM23A for diagnosis of RCC: Renal Cell Carcinoma
Urologia JournalObjective: This study investigates the diagnostic potential of nicotinamide N-methyltransferase (NNMT) and NM23A as biomarkers for renal cell carcinoma (RCC), focusing on their ability to facilitate early detection and improve diagnostic precision ...
Soumya Ranjan Behera +8 more
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NNMT is involved in deoxynivalenol-induced hepatocyte toxicity via promoting ferroptosis
ToxicologyDeoxynivalenol (DON) is a common contamination mycotoxin that which exerts significant hepatotoxicity, posing a serious threat to human and animal health. Ferroptosis has been linked to the development of hepatotoxicity induced by DON. However, the mechanism by which DON promotes ferroptosis in hepatocytes is not well understood.
Weiling, Huang +3 more
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Pharmacological inhibition of nicotinamide N-methyltransferase (NNMT) in adipocytes by romidepsin
Diabetologie und Stoffwechsel, 2016Background: Expression of nicotinamide N-methyltransferase (NNMT) is increased in adipose tissue in obesity. Fat-specific knockdown of NNMT with antisense oligonucleotides (ASO) prevents diet-induced obesity in mice. In cultured adipocytes however, transfection efficiency of ASO is poor.
B Zapp +5 more
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Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder
Gene, 2013Here we report the association of the rs694539 variant of nicotinamide-N-methyltransferase gene with bipolar disorder in a case-control study of 95 bipolar disorder patients and 201 healthy controls (χ(2)=13.382, P=0.001). With the polymerase chain reaction restriction fragment length polymorphism method we developed we were able to show the ...
Ozel, MD +3 more
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NNMT suppresses H3K9me3 to facilitate malignant progression and drug resistance in gastric cancer
Arab Journal of GastroenterologyNicotinamide N-methyltransferase (NNMT) is aberrantly expressed in tumors and is implicated in the progression and chemoresistance of cancers. This project attempts to explore the specific molecular mechanism by which NNMT enhances 5-fluorouracil (5-FU) resistance in gastric cancer (GC).By bioinformatics analysis, the expression of NNMT in GC was ...
Bo Wang, Tao Wu
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