Results 1 to 10 of about 14,257 (250)

INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay [PDF]

Viruses, 2021
Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral compounds that prevent the insertion of a DNA copy of the viral genome into the host genome by targeting the viral enzyme integrase (IN).
Steven J. Smith, Andrea Ferris, Xuezhi Zhao, Gary Pauly, Joel P. Schneider, Terrence R. Burke, Stephen H. Hughes   +6 more
doaj   +2 more sources

HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate [PDF]

Viruses, 2010
HIV-1 reverse transcriptase (RT) inhibitors currently used in antiretroviral therapy can be divided into two classes: (i) nucleoside analog RT inhibitors (NRTIs), which compete with natural nucleoside substrates and act as terminators of proviral DNA ...
Giovanni Maga, Marco Radi, Marie-Aline Gerard, Maurizio Botta, Eric Ennifar   +4 more
doaj   +2 more sources

Genotype resistance profiles in patients failing an NNRTI‐containing regimen, and modifications after stopping NNRTI therapy [PDF]

Journal of Clinical Laboratory Analysis, 2002
AbstractResistance to non‐nucleoside reverse transcriptase inhibitors (NNRTIs) develops quickly and independently if they are used in combination with NRTIs or protease inhibitors (PIs) as rescue therapy, mainly due to the low genetic barrier of this class of drugs.
QUIROS ROLDAN, Maria Eugenia, Airoldi M, Moretti F, Fausti C, Pan A, CASARI, Salvatore, TORTI, Carlo, CASTELLI, Francesco, CAROSI, Giampiero   +8 more
openaire   +5 more sources

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

Acta Pharmaceutica Sinica B, 2020
Human immunodeficiency virus (HIV) is the primary infectious agent of acquired immunodeficiency syndrome (AIDS), and non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the cornerstone of HIV treatment.
Chunlin Zhuang, Christophe Pannecouque, Erik De Clercq, Fener Chen   +3 more
doaj   +2 more sources

Pre-treatment and acquired HIV drug resistance in Hunan: a cross-sectional analysis of a growing challenge [PDF]

BMC Infectious Diseases
Background HIV Drug Resistance (HIVDR) is a key consideration when determining ART regimens. In recent years, Pre-treatment Drug Resistance (PDR) and Acquired Drug Resistance (ADR) have been changing rapidly.
Shujing Long, Run Yao, Yumei Tang, Chengcheng Yu, Wei Tang, Jing Cao, Yaxiong Huang, Xinlan Lu, Sai Li, Rangjiao Liu, Lizhong Dai, Yan Huang, Fang Zheng   +12 more
doaj   +2 more sources

Brief communication: characteristics of primary drug resistance in newly diagnosed HIV-infected individuals in Ganzhou, China [PDF]

AIDS Research and Therapy
Background Primary drug resistance (PDR) is an important cause of antiretroviral therapy (ART) failure. However, the prevalence and characteristics of PDR in Ganzhou remain unclear.
Dan-Dan Huang, Jun-Jie Liu, Ya-Ting Chen, Rong-Rong Yang, Jun-Zhi Su, Qian Gao, Xin Chen   +6 more
doaj   +2 more sources

Prevalence of Doravirine Resistance Mutations in a Large-Scale HIV-1 Transmitted Drug Resistance Survey in Buenos Aires, Argentina [PDF]

Viruses
Background: Argentina has reported moderate to high levels of transmitted drug resistance in people living with HIV/AIDS (PLWHA), mostly to non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Diego Cecchini, Isabel Cassetti, Florencia Scarnato, Agustina Fiori, Jimena Nuevo, Clara Villaverde, Adriana Sucari, María C. Torroija, Emiliano Bissio, Gabriela Bugarin, Gustavo Lopardo   +10 more
doaj   +2 more sources

2507. Transmitted and Acquired NNRTI Resistance in the Philippines: Are Newer Generation NNRTIs a Viable Option? [PDF]

Open Forum Infectious Diseases, 2019
Abstract Background Doravirine, rilpivirine, and etravirine are newer generation non-nucleoside reverse transcriptase inhibitors (NNRTI) that are intended to be more durable alternatives to efavirenz and nevirapine.
Theresa Dungca, Nina, Schwem, Brian, Arevalo, Geraldine, Francisco, Christian, Penalosa-Ramos, Christine, Ching, Patrick, Leyritana, Katerina, Destura, Raul, Lim, Jodor, Tactacan-Abrenica, Rosario, Telan, Elizabeth, Solante, Rontgene, Samonte, Genesis, Trinidad, Lyka, Mendoza, Kevin, Alejandria, Marissa M, Salvana, Edsel Maurice T   +16 more
openaire   +2 more sources

TMC278, a Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI), Active against Wild-Type and NNRTI-Resistant HIV-1 [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACTNonnucleoside reverse transcriptase inhibitors (NNRTIs) have proven efficacy against human immunodeficiency virus type 1 (HIV-1). However, in the setting of incomplete viral suppression, efavirenz and nevirapine select for resistant viruses.
Hilde, Azijn, Ilse, Tirry, Johan, Vingerhoets, Marie-Pierre, de Béthune, Guenter, Kraus, Katia, Boven, Dirk, Jochmans, Elke, Van Craenenbroeck, Gaston, Picchio, Laurence T, Rimsky   +9 more
openaire   +3 more sources

Cumulative effects of hypertriglyceridemia in HIV-infected patients switching from NNRTIs to PI-based antiretroviral therapy

Journal of Infection in Developing Countries, 2022
Introduction: The objective of this study was to investigate changes in serum lipids among HIV-infected patients switching from non-nucleoside-reverse transcriptase inhibitors (NNRTI) to protease inhibitor (PI)-based highly active antiretroviral therapy
Yu Zhang, Jiang Xiao, Wen Zhang, Ning Han, Di Yang, Wei Liu, Hui Zeng, Junyan Han, Hongxin Zhao   +8 more
doaj   +1 more source