Results 101 to 110 of about 14,257 (250)

Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy

African Journal of Laboratory Medicine, 2018
Background: Minority drug resistance mutations (DRMs) that are often missed by Sanger sequencing are clinically significant, as they can cause virologic failure in individuals treated with antiretroviral therapy (ART) drugs.
Zhiyong Zhou, Kevin Tang, Guoqing Zhang, Nellie Wadonda-Kabondo, Kundai Moyo, Lori A. Rowe, Joshua R. DeVos, Nick Wagar, Du-Ping Zheng, Hongxiong Guo, John Nkengasong, Mike Frace, Scott Sammons, Chunfu Yang   +13 more
doaj   +1 more source

Immunological Effects of Integrase Inhibitors versus Protease and Non-Nucleoside Reverse Transcriptase Inhibitors as Part of Initial Therapy in People Living with HIV. A Systematic Review

Iatreia
Introduction: The use of integrase inhibitors within highly active antiretroviral therapy (HAART) has demonstrated benefits for individuals living with HIV.
Melissa Gutiérrez-Gómez, Sofía Giraldo-Hoyos, Salomón Gallego-Quintero, Natalia Taborda-Vanegas, María Teresa Rugeles-López, Juan Carlos Alzate-Ángel   +5 more
doaj   +1 more source

HIV-1 reverse transcriptase and protease mutations for drug-resistance detection among treatment-experienced and naïve HIV-infected individuals.

PLoS ONE, 2020
BACKGROUND:The presence of drug resistance mutations (DRMs) against antiretroviral agents is one of the main concerns in the clinical management of individuals with human immunodeficiency virus-1 (HIV-1) infection, especially in regions of the world ...
Farah Bokharaei-Salim, Maryam Esghaei, Khadijeh Khanaliha, Saeed Kalantari, Arezoo Marjani, Atousa Fakhim, Hossein Keyvani   +6 more
doaj   +1 more source

In Silico Induction of Missense Mutation in NNRTI Protein: Computational Modelling Studies on Design of Modelled Proteins and their Stability Studies. [PDF]

, 2023
Laxmi Sule, Swagata Gupta, Nilanjana Jain, Nitin S. Sapre   +3 more
openalex   +1 more source

HIV Drug Resistance Mutations in Patients with HIV and HIV-TB Coinfection After Failure of First-Line Therapy: A Prevalence Study in a Resource-Limited Setting

Journal of the International Association of Providers of AIDS Care, 2019
Introduction: The present study aimed to report the prevalent HIV-1 drug-resistant mutations in patients with HIV-1 alone and tuberculosis (TB) coinfection alone to improve our understanding of the mutation patterns and aid treatment decisions.
Nawaid Hussain Khan PhD, Mikashmi Kohli PhD, Kartik Gupta MD, Bimal Kumar Das MD, Ravindra Mohan Pandey PhD, Sanjeev Sinha MD   +5 more
doaj   +1 more source

Structure–Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs [PDF]

, 2020
Dongwei Kang, Yanying Sun, N. Arul Murugan, Da Feng, Fenju Wei, Jing Li, Xiangyi Jiang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu   +10 more
openalex   +1 more source

Evaluation of HIV Protease Inhibitor Use and the Risk of Sudden Death or Nonhemorrhagic Stroke [PDF]

, 2017
Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjusted rate ratio, 1.22; 95 ...
Dabis, F., De Wit, S., D′Arminio Monforte, A., El-Sadr, W., Fontas, E., Kamara, D. A., Law, M., Lundgren, J. D., Phillips, A., Reiss, P., Ryom, L., Sabin, C., Weber, R., Worm, S. W.   +13 more
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5-arylaminouracil derivatives as potential dual-action agents [PDF]

, 2015
Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium tuberculosis growth at concentrations of 5-40 μg/mL are demonstrated to act also as noncompetitive non-nucleoside inhibitors of HIV-1 reverse transcriptase without
Babkov, DA, CORONA, ANGELA, Khandazhinskaya, AL, Kochetkov, SN, Margolis, LB, Matyugina, ES, Novikov, MS, TRAMONTANO, ENZO, Valuev Elliston, VT, Vanpouille, C, Zicari, S   +10 more
core   +1 more source

Effectiveness of boosted lopinavir versus boosted atazanavir in HIV-1 infected patients switching to second-line antiretroviral therapy following failure of an NNRTI first line ART in a low/middle-income setting, a retrospective cohort study: the BaLANCe study [PDF]

, 2018
Carina César, María José Rolón, A. Sisto, G. Blugerman, F. Cahn, Chikayo Yamamoto, Colleen Wegzyn, Tshepiso Madihlaba, Henar Hevia Pérez, Pedro Cahn   +9 more
openalex   +1 more source

Efficacy of 1998 vs 2006 first-line antiretroviral regimens for HIV infection: an ordinary clinics retrospective investigation [PDF]

, 2012
Purpose: The evidence suggesting increased HAART efficacy over time comes from randomized trials or cohort studies. This retrospective multicenter survey aimed to assess the variation over time in the efficacy and tolerability of first-line HAART ...
Antinori, Andrea, Bonfanti, Paolo, Celesia, Benedetto Maurizio, Dalessandro, Margherita, De Socio, Giuseppe Vittorio Luigi, Di Masi, Francesco, Madeddu, Giordano, Manzoli, Lamberto, Marconi, Patrizia, Martinelli, Canio, Mazzotta, Elena, Mura, Maria Stella Anna, Nigro, Luciano, Parruti, Giustino, Pellicanò, Giovanni, Polilli, Ennio, Ricci, Elena, Soddu, Viviana, Sozio, Federica, Ursini, Tamara, Vecchiet, Jacopo, Vitiello, Paola   +21 more
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