Results 111 to 120 of about 14,257 (250)

HIV drug resistance prediction with weighted categorical kernel functions [PDF]

, 2019
Background: Antiretroviral drugs are a very effective therapy against HIV infection. However, the high mutation rate of HIV permits the emergence of variants that can be resistant to the drug treatment.
Belanche Muñoz, Luis Antonio, Pérez Enciso, Miguel, Ramon Gurrea, Elies   +2 more
core   +3 more sources

Antiretroviral Therapy Reduces Markers of Endothelial and Coagulation Activation in Patients Infected with Human Immunodeficiency Virus Type 1 [PDF]

, 2017
We investigated the effect of antiretroviral therapy on vascular activation in 41 human immunodeficiency (HIV)—infected patients receiving a regimen that included either at least 1 protease inhibitor (PI; n = 21) or a nonnucleoside reverse-transcriptase ...
Battegay, Manuel, Erb, Peter, Tsakiris, Dimitrios A., Weber, Rainer, Wolf, Katja   +4 more
core  

Variations of CYP3A activity induced by antiretroviral treatment in HIV-1 infected patients [PDF]

, 2018
Objective: To measure the in vivo variations of CYP3A activity induced by anti-HIV drugs in human immunodeficiency virus (HIV)1-positive patients. Methods: A low oral dose of midazolam (MID) (0.075mg) was given to the patients and the 30-min total 1-OH ...
Baumann, Pierre, Buclin, Thierry, Decosterd, Laurent, Eap, Chin, Fellay, Jacques, Golay, Kerry, Marzolini, Catia, Telenti, Amalio   +7 more
core  

2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies

, 2021
Dongwei Kang, Francesc X. Ruiz, Yanying Sun, Da Feng, Lanlan Jing, Zhao Wang, Tao Zhang, Shenghua Gao, Lin Sun, Erik De Clercq, Christophe Pannecouque, Eddy Arnold, Peng Zhan, Xinyong Liu   +13 more
openalex   +2 more sources

Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs: Crystallographic overlay-based molecular design, synthesis, and biological evaluation

, 2022
Da Feng, Hao Lin, Liyang Jiang, Jiaojiao Dai, Xiaoying Zhang, Zhongxia Zhou, Yanying Sun, Zhao Wang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu   +12 more
openalex   +1 more source

Antiretroviral resistance patterns and factors associated with resistance in adult patients failing NNRTI‐based regimens in the western cape, South Africa [PDF]

, 2011
Gert U. van Zyl, Lize van der Merwe, Mathilda Claassen, M. Zeier, Wolfgang Preiser   +4 more
openalex   +1 more source

Molecular dynamics simulations and docking of non-nucleoside reverse transcriptase inhibitors (NNRTIs): a possible approach to personalized HIV treatment [PDF]

, 2012
Florian D. Roessler, Oliver Korb, Andreas Bender, Werner Maentele, Peter J. Bond   +4 more
openalex   +1 more source

Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy [PDF]

, 2020
Yuan Lei, Sheng Han, Yang Yang, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen   +6 more
openalex   +1 more source

Targeting HIV-1 RNase H: N’-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants [PDF]

, 2020
Angela Corona, Ester Ballana, Simona Distinto, Dominga Rogolino, Claudia Del Vecchio, Mauro Carcelli, Roger Badía, Eva Riveira‐Muñoz, Francesca Esposito, Cristina Parolin, José A. Esté, Nicole Grandi, Enzo Tramontano   +12 more
openalex   +1 more source

Antiretroviral Drug Resistance Testing in Adult HIV-1 Infection: 2008 Recommendations of an International AIDS Society-USA Panel [PDF]

, 2017
Resistance to antiretroviral drugs remains an important limitation to successful human immunodeficiency virus type 1 (HIV-1) therapy. Resistance testing can improve treatment outcomes for infected individuals.
Clotet, Bonaventura, Günthard, Huldrych F., Hammer, Scott M., Hirsch, Martin S., Jacobsen, Donna M., Johnson, Victoria A., Kuritzkes, Daniel R., Mellors, John W., Pillay, Deenan, Richman, Douglas D., Schapiro, Jonathan M., Vézinet, Françoise Brun, Yeni, Patrick G.   +12 more
core