Results 221 to 230 of about 14,257 (250)

Novel indole sulfides as potent HIV-1 NNRTIs

Bioorganic & Medicinal Chemistry Letters, 2016
In a previous communication we described a series of indole based NNRTIs which were potent inhibitors of HIV replication, both for the wild type and K103N strains of the virus. However, the methyl ether functionality on these compounds, which was crucial for potency, was susceptible to acid promoted indole assisted SN1 substitution.
Siobhan Brigg, Nicole Pribut, Adriaan E. Basson, Moscos Avgenikos, Reinhardt Venter, Margaret A. Blackie, Willem A.L. van Otterlo, Stephen C. Pelly   +7 more
openaire   +2 more sources

Non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Expert Opinion on Investigational Drugs, 1994
Various non-nucleoside reverse transcriptase inhibitors (NNRTIs) have been reported to specifically inhibit human immunodeficiency virus type 1 (HIV-1): for example, tetrahydroimidazobenzodiazepinone (TIBO), hydroxyethoxymethylphenylthiothymine (HEPT), dipyridodiazepinone (i.e.
openaire   +1 more source

Novel Pyridinone Derivatives As Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) with High Potency against NNRTI-Resistant HIV-1 Strains

Journal of Medicinal Chemistry, 2013
Novel 6-substituted-4-cycloalkyloxy-pyridin-2(1H)-ones were synthesized as non-nucleoside reverse transcriptase inhibitors (NNRTIs), and their biological activity was evaluated. Most of the compounds, especially 26 and 22, bearing a 3-isopropyl and 3-iodine group, respectively, exhibited highly potent activity against wild-type HIV-1 strains and those ...
Amin, Li, Yabo, Ouyang, Ziyun, Wang, Yuanyuan, Cao, Xiangyi, Liu, Li, Ran, Chao, Li, Li, Li, Liang, Zhang, Kang, Qiao, Weisi, Xu, Yang, Huang, Zhili, Zhang, Chao, Tian, Zhenming, Liu, Shibo, Jiang, Yiming, Shao, Yansheng, Du, Liying, Ma, Xiaowei, Wang, Junyi, Liu   +20 more
openaire   +2 more sources

Neuer NNRTI zugelassen

CME, 2019
  +4 more sources

NNRTI TBZ analoghi: progettazione razionale, sintesi e SAR

2004
Pisa
BARRECA M. L, RAO A, DE LUCA, Laura, MONFORTE, Anna Maria, ZAPPALA', Maria, MAGA G, DE CLERCQ E, CHIMIRRI, Alba, MONFORTE P.   +8 more
openaire   +4 more sources

A Novel NNRTI Class with Potent Anti-HIV Activity Against NNRTI-resistant Viruses

Antiviral Research, 2008
Anneke Raney, Robert Hamatake, Wen Xu, Jean-Luc Girardet, Jean-Michel Vernier, Li-Tain Yeh, Barry Quart   +6 more
openaire   +1 more source

NNRTI-related or -unrelated hepatotoxicity?

Hepatology, 2002
Pascal, Lebray, Yves, Benhamou, Stanislas, Pol, Robert P, Myers, Thierry, Poynard, Vincent, Di Martino   +5 more
openaire   +2 more sources

Review of NNRTIs: 'today and tomorrow'.

International journal of clinical practice. Supplement, 2000
Since 1996 indinavir in combination with zidovudine + lamivudine has been the standard regimen in the treatment of HIV infection. Although protease inhibitor (PI) containing therapies are very potent, many problems have now been identified that reduce quality of life such as a high pill burden, multiple daily dosing and dietary constraints. In addition,
openaire   +1 more source

Next generation NNRTI potent against NNRTI-resistant HIV-1

Inpharma Weekly, 2005
openaire   +1 more source

NNRTIs: challenges and opportunities

Inpharma Weekly, 2002
openaire   +1 more source