TSAO compounds: The comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase [PDF]
, 2004 Emergence of drug-resistant viral strains is one of the major milestones and the main cause for the failure of antiretroviral therapy. Combination of different anti-HIV agents has E become the standard clinical practice to keep the viral load at low or ...
Balzarini, Jan +5 more
core +4 more sources
Journal of Global Antimicrobial Resistance, 2023 : Objectives: We aimed to evaluate the prevalence and characteristics of people living with HIV (PLWH) eligible for the long-acting injectable (LAI) regimen with cabotegravir (CAB) and rilpivirine (RPV), in comparison with ineligible individuals ...
Adriana Cervo +14 more
doaj +1 more source
Emergence of an NNRTI Resistance Mutation Y181C in an HIV-Infected NNRTI-Naive Patient
AIDS Research and Human Retroviruses, 2008 The purpose of our study was to examine the emergence of the Y181C resistance mutation in an NNRTI-naive subject (index patient) at different time points. Phylogenetic trees in protease (PR) and partial reverse transcriptase (RT) regions were inferred by the maximum likelihood (ML) method.
Magiorkinis, E. +6 more
openaire +3 more sources
Trends on epidemiological, virological, and clinical features among newly diagnosed HIV-1 persons in Northwest Spain over the last 10 years [PDF]
, 2015 [Abstract] To describe temporal trend and characteristics of newly HIV-diagnosed patients in a medical care area in Northwest Spain over the last 10 years.
Castro-Iglesias, Ángeles +7 more
core +2 more sources
A Retrospective Survey of HIV Drug Resistance Among Patients 1 Year After Initiation of Antiretroviral Therapy at 4 Clinics in Malawi [PDF]
, 2012 In 2004, Malawi began scaling up its national antiretroviral therapy (ART) program. Because of limited treatment options, population-level surveillance of acquired human immunodeficiency virus drug resistance (HIVDR) is critical to ensuring long-term ...
Anthony Harries +40 more
core +2 more sources
3D QSAR Studies of DAMNI Analogs as Possible Non-nucleoside Reverse Transcriptase Inhibitors
E-Journal of Chemistry, 2008 The non-nucleoside inhibitors of HIV-1-reverse transcriptase (NNRTIs) are an important class of drugs employed in antiviral therapy. Recently, a novel family of NNRTIs commonly referred to as 1-[2-diarylmethoxy] ethyl) 2-methyl-5-nitroimidazoles (DAMNI ...
S. Ganguly, V. Gopalakrishnan
doaj +1 more source
The “Connection” Between HIV Drug Resistance and RNase H
Viruses, 2010 Currently, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are two classes of antiretroviral agents that are approved for treatment of HIV-1 infection. Since both NRTIs and NNRTIs target the
Krista A. Delviks-Frankenberry +2 more
doaj +1 more source
Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition [PDF]
, 2011 Background LINE-1s (L1, Long Interspersed Element-1) are the most abundant autonomous non-LTR retrotransposons in the human genome and replicate by reverse transcription of an RNA intermediate.
Lixin Dai, Qing Huang, Jef D Boeke
core +1 more source
Observational epidemiological study to identify the clinical profile of naïve patients starting antiretroviral (ARV) therapy in Spain [PDF]
, 2012 Purpose of the study: To identify the proportion of patients starting ARV treatment with NNRTIs or with a PI/r and to explore and compare their clinical profile establishing different factors whereby physicians select the initial ARV treatment in a ...
A Ocampo, F Ledesma, H Hevia, P Viciana
core +1 more source
HIV-1 drug mutations in children from northern Tanzania [PDF]
, 2014 Objectives: In resource-limited settings, it is a challenge to get quality clinical specimens due to poor infrastructure for their collection, transportation, processing and storage. Using dried blood spots (DBS) might be an alternative to plasma for HIV-
Shao, Elichilia R. +9 more
core +2 more sources