Results 81 to 90 of about 14,257 (250)

Comparative effectiveness of dolutegravir + lamivudine versus three‐drug regimens in Swedish clinical practice: a nationwide study

Journal of the International AIDS Society, Volume 29, Issue 3, March 2026.
Abstract Introduction HIV guidelines recommend switching from a three‐drug regimen (3DR) to dolutegravir + lamivudine (DTG+3TC) for eligible individuals. This retrospective national cohort study used Swedish InfCareHIV registry data to evaluate long‐term outcomes of adults with HIV RNA <50 copies/ml who switched to DTG+3TC or a guideline‐recommended ...
Erik Sörstedt, George Nduva, Fredrik Månsson, Åsa Mellgren, Johanna Repits, Eva Fernvik, Adam Stubbs, Melanie Schroeder, Johanna Brännström, Christina Carlander   +9 more
wiley   +1 more source

Genetic subtypes and drug resistance in untreated patients with HIV-1 infection in Qingdao, China: An analysis of 113 cases [PDF]

精准医学杂志
Objective To investigate genetic subtypes and drug resistance in untreated patients with HIV-1 infection in Qingdao. Methods A retrospective analysis was performed for the genetic subtypes, drug resistance, and other clinical data of patients with new ...
WANG Hong, LI Hongbo, SUN Chunfeng, LI Xiang, XU Guangyong
doaj   +1 more source

1597. Randomized-Controlled Trial Evaluating The Outcome Between Switching to Tenofovir Disoproxil Fumarate(TDF)/Lamivudine(3TC)/Dolutegravir(DTG) Versus Maintaining The Current NNRTI Or Boosted-PI-containing Regimen in PLWH in Thailand – A Pilot Study from Single Center [PDF]

, 2023
Samadhi Patamatamkul, Kongkarn Chancharusiri, Opass Putcharoen   +2 more
openalex   +1 more source

A multivariate analysis on non-nucleoside HIV-1 reverse transcriptase inhibitors and resistance induced by mutation [PDF]

, 2004
This paper describes the use of multivariate statistical procedure PCA as a tool to explore the inhibitory activity of classes of NNRTIs against HIV-1 viruses (wild type and more frequent mutants, Y181C, V106A, K103N, L100I) and against RT enzyme.
Arranz, Bacheler, Balzarini, Buckheit, Campiani, Carbo, Clercq, Clercq, Corbett, Hajos, Huberty, Manly, Petropoulos, Silvestri, Tramontano, Xu, Zembower   +16 more
core   +1 more source

Association Between Patatin‐Like Phospholipase Do‐Main‐Containing Protein‐3 Variant and Cardiovascular Disease Risk in People Living With HIV on Antiretroviral Therapy in Taiwan: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Cardiovascular disease (CVD) risk is elevated among people living with HIV (PLWH), particularly those receiving antiretroviral therapy (ART). This study aimed to examine associations between single‐nucleotide polymorphisms (SNPs) in lipoprotein‐related genes and CVD risk among PLWH undergoing ART. Methods Blood samples from
Chia‐Hui Yu, Gwo‐Tarng Sheu, Chien‐Feng Li, Win‐Long Lu, Hao‐Jan Yang, Hung‐Chang Hung, Yuan‐Ti Lee   +6 more
wiley   +1 more source

Prodrug design, synthesis and pharmacokinetic evaluation of (3′R, 4′R)-3-hydroxymethyl-4-methyl-3′, 4′-di-O-(S)-camphanoyl-(+)-cis-khellactone

Acta Pharmaceutica Sinica B, 2012
3-Hydroxymethyl-4-methyl-DCK (3, HMDCK) was discovered previously as a potent HIV non-nucleoside reverse transcriptase inhibitor (NNRTIs) (EC50: 0.004 μM, TI: 6225) with a novel mechanism of action.
Huanfang Guo, Xiaomei Zhuang, Keduo Qian, Lianqi Sun, Xiaofeng Wang, Hua Li, Kuohsiung Lee, Lan Xie   +7 more
doaj   +1 more source

Antiretroviral drug resistant HIV-1 in women and children living in Honduras [PDF]

, 2013
Antiretroviral therapy (ART) in HIV infected pregnant women contributes to the prevention of HIV transmission to the newborn. However, as ART can also induce HIV drug resistance during suboptimal levels of virological suppression a major concern is the ...
Parham, Leda
core   +1 more source

HIV low‐level viraemia: considerations for prevention and treatment in an era of highly effective and durable antiretroviral therapy regimens

Journal of the International AIDS Society, Volume 29, Issue 2, February 2026.
Abstract Introduction Despite increasingly widespread acceptance of the (undetectable = untransmittable) U = U concept, uncertainty remains about the implications of suppressed viral loads (detected but ≤1000 copies/ml, also often referred to as low‐level viraemia) for both sexual HIV transmission and individual patient outcomes.
Lara Vojnov, Linda‐Gail Bekker, Myron S. Cohen, Andreas Jahn, Diane Havlir, Debrah Boeras, Nathan Ford, Nagalingesawaran Kumarasamy, Laura N. Broyles   +8 more
wiley   +1 more source

Long-term treatment outcomes of ritonavir-boosted lopinavir monotherapy among HIV-infected patients who experienced NRTI and NNRTI failure [PDF]

, 2012
Background We continue the previously described prospective cohort study of ritonovir-boosted lopinavir (LPV/r) monotherapy for second-line therapy in HIV-infected patients with prior failure and extensive resistance to nucleoside reverse transcriptase ...
Weerawat Manosuthi, Supeda Thongyen, Samruay Nilkamhang, Sukanya Manosuthi, Somnuek Sungkanuparph   +4 more
core   +2 more sources

Recent Developments in HIV Antivirals: The Prospect of Prophylactic Drugs to Change the Pandemic

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
Replication cycle of HIV‐1. The scheme provides an overview from virus entry over reverse transcription of viral RNA into viral DNA, provirus DNA integration into the host genome, genome expression by transcription and translation, proteolytic processing of the viral polyproteins, viral maturation to viral release from the cell. The various targets for
Harald Brüssow
wiley   +1 more source