Results 251 to 260 of about 3,155,563 (287)

No-observed-adverse-effect level of hair pyrrole adducts in chronic n-hexane intoxication in rats

NeuroToxicology, 2020
n-Hexane has been reported to induce serious peripheral neuropathy in workers. Pyrrole adducts are the unique reaction products of n-hexane in organisms and have been demonstrated to be critical to n-hexane neuropathy. Our previous studies have demonstrated that pyrrole adducts could accumulate in hair and showed high correlation with neuropathy at the
Xianjie Li, Lulu Jiang, Ting Yu, Ming Li, Qiong Wang, Zhidan Liu, Keqin Xie   +6 more
openaire   +2 more sources

Predictability and prediction of lowest observed adverse effect levels in a structurally heterogeneous set of chemicals

SAR and QSAR in Environmental Research, 2005
A database of chronic lowest observed adverse effect levels (LOAELs) for 234 compounds, previously compiled from different sources (Toxicology Letters79, 131-143 (1995)), was modelled using graph theoretical descriptors. This study reveals that data are not homogeneous. Only those data originating from the U.S.
J V, de Julián-Ortiz, R, García-Domenech, J, Gálvez, L, Pogliani   +3 more
openaire   +2 more sources

Developmental toxicity of carbendazim: comparison of no-observed-adverse-effect level and benchmark dose approach

Food and Chemical Toxicology, 1998
The benchmark dose (BD) approach has been applied to foetal data from four gavage segment II studies (rat studies 1 and 2, rabbit study, hamster study) on the teratogenic benzimidazole carbendazim. Nineteen parameters were assessed using the log-normal model as a practical tool to derive BDs; good model fitting was observed for all except two ...
A, Mantovani, F, Maranghi, C, Ricciardi, C, Macrì, A V, Stazi, L, Attias, G A, Zapponi   +6 more
openaire   +2 more sources

Estimating equivalent human concentrations of no observed adverse effect levels: a comparison of several methods

Experimental Pathology, 1989
Four methods for intra- and inter-species dose extrapolation for inhalation reference doses are discussed. Dichloromethane is used as an example to illustrate quantitative differences in the methods. The methods include a procedure recommended by the U.S.
J H, Overton, A M, Jarabek
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A new approach to deriving community exposure guidelines from “no-observed-adverse-effect levels”

Regulatory Toxicology and Pharmacology, 1990
The world community desires accurate and reliable information about possible health hazards from exposure to chemicals in the environment. For example, Title III of the Superfund Amendments and Reauthorization Act (SARA, U.S. Congress, 1986) requires plant operators to disclose data on air, water, and waste emissions for over 300 chemicals.
S C, Lewis, J R, Lynch, A I, Nikiforov
openaire   +2 more sources

Confirmation of an acute no-observed-adverse-effect and low-observed-adverse-effect level for copper in bottled drinking water in a multi-site international study

Regulatory Toxicology and Pharmacology, 2003
In a double blind, 3x3 factorial (volumexdose) study, 70 adult females (18-60 years of age) at four different international sites (total pooled n=269) were given 100, 150, or 200ml of bottled drinking water with 0.4, 0.8, or 1.2mg of copper (Cu) as the sulfate salt once each week.
Araya, Magdalena, Chen, Bingheng, Klevay, Leslie M., Strain, J. J., Johnson, Luann, Robson, Paula, Shi, Wei, Nielsen, Forrest, Zhu, Huigang, Olivares Grohnert, Manuel, Pizarro Aguirre, Fernando, Haber, Lynne T.   +11 more
openaire   +4 more sources

Determination of no-observed-adverse-effect levels and eliciting doses in a representative group of peanut-sensitized children

Journal of Allergy and Clinical Immunology, 2006
Current labeling practices for allergenic foods like peanut can be inadequate. For future regulatory and industry guidelines, information on no-observed-adverse-effect levels (NOAELs) and eliciting doses (EDs) for allergenic foods is necessary.To determine NOAEL and ED in a representative group of peanut-sensitized children, relate these data to ...
Annebeth E, Flinterman, Suzanne G, Pasmans, Maarten O, Hoekstra, Yolanda, Meijer, Els, van Hoffen, Edward F, Knol, Susan L, Hefle, Carla A, Bruijnzeel-Koomen, André C, Knulst   +8 more
openaire   +2 more sources

Low‐level exposure of guinea pigs and marmosets to sarin vapour in air: lowest‐observable‐adverse‐effect level (LOAEL) for miosis

Journal of Applied Toxicology, 2004
AbstractThe purpose of this pilot study was to indicate, for low‐level exposure of conscious guinea pigs and marmoset monkeys to sarin vapour in air, the lowest‐observable‐adverse‐effect level (LOAEL) of sarin for miosis. This is the concentration × time (C·t) value (t = 5 h) of exposure at which miosis becomes significant.The ratio of pupil and iris ...
Helden, H.P.M. van, Trap, H.C., Kuijpers, W.C., Oostdijk, J.P., Benschop, H.P., Langenberg, J.P.   +5 more
openaire   +3 more sources

[Study of No Observed Adverse Effect Level of Nickel and Its Preliminary Evaluation Biocompatibility].

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation, 2020
The purpose of this study was to investigate the NOAEL of the nickel ion and provide with basic data for the biological evaluation of those medical devices containing nickel. Five groups SD rats were repeatedly exposed during 14 d respectively to nickel at first stage doses of 4.9, 3.7, 2.5 mg/(kg.d), and the second stage doses of 1.2, 0.25 mg/(kg.d ...
Xueying, He, Juli, Tang, Xiantao, Wen, Bo, Guan, Rui, Wang, Hui, Wang, Hua, Li, Jianfeng, Shi, Yali, Zeng, Yongjian, Mao   +9 more
openaire   +1 more source

Comparison of benchmark doses (BMD) with no-observed-adverse-effect-levels (NOAELs) and low-observed-adverse-effect-levels (LOAELs) for subchronic toxicity studies

Toxicology Letters, 1994
R.S. Nair, M.A. Martens
openaire   +1 more source