Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations [PDF]
MethodsX, 2021 The number of studies reporting hormetic responses is rapidly increasing, and quantitative evaluations are needed to improve the understanding of hormetic dose responses.
Evgenios Agathokleous +2 more
doaj +4 more sources
Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL) [PDF]
Toxins, 2017 Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Paula Abal +7 more
doaj +4 more sources
Hormesis Shifts the No-Observed-Adverse-Effect Level (NOAEL) [PDF]
Dose-Response, 2021 Data from recent dose-response toxicological studies suggest that the no-observed-adverse-effect-level (NOAEL) may depend upon whether hormesis is present. A further examination of these data supports this hypothesis by showing that the NOAEL was greater
Evgenios Agathokleous +2 more
doaj +2 more sources
QSAR Models for Repeated Dose Toxicity in Rats Using the CORAL Software [PDF]
ToxicsThe evaluation of the safety of chemical substances requires the identification of a safe dose, which has no adverse effects on humans. This is obtained through animal studies, with exposure prolonged for months.
Alla P. Toropova +5 more
doaj +2 more sources
CORAL: model for no observed adverse effect level (NOAEL) [PDF]
Molecular Diversity, 2015 Andrey A Toropov +2 more
exaly +2 more sources
A comparative biodistribution and toxicity study of single and multi-component nanomaterials: NMs: TiO2, SiC, and SiC@TiO2 [PDF]
Particle and Fibre ToxicologyBackground With the increasing integration of nanomaterials (NMs) into daily life, their technological advantages have become evident. However, their intricate interactions with biological systems introduce complexities that can lead to unpredictable ...
Wenting Zhang +6 more
doaj +2 more sources
Toxicology Reports, 2021 Thinned immature fruit of the mango tree (Mangifera indica ‘Irwin’) are handled as waste. In this study, we conducted a 90-days toxicity study in male and female Sprague Dawley rats to evaluate the safety of a hot-water extract of thinned immature mango ...
Hayato Tajiri +6 more
doaj +1 more source
Safety, toxicity and pharmacokinetic assessment of oral Withaferin-A in mice
Toxicology Reports, 2022 Withaferin-A (WA) is the principle component of Withania somnifera (Ashwagandha). It has several biological activities including anti-cancer, anti-diabetic, neuroprotective, hepatoprotective and immune-modulatory properties.
Saurabh Kumar Gupta +8 more
doaj +1 more source
Environment International, 2021 Humans carry residues of multiple synthetic chemicals at any given point in time. Research has demonstrated that compounds with varying molecular initiating events (MIE) that disrupt common key events can act in concert to produce cumulative adverse ...
Justin M. Conley +6 more
doaj +1 more source
Assessment of information as regards the toxicity of deoxynivalenol for horses and poultry
EFSA Journal, 2023 In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks for animal health related to the presence of deoxynivalenol (DON) and its acetylated and modified forms in food and feed.
EFSA Panel on Contaminants in the Food Chain (CONTAM) +20 more
doaj +1 more source