Results 11 to 20 of about 7,937 (163)

Effect of the neonicotinoid pesticide clothianidin at a no-observed-adverse-effect-level (NOAEL) dose on maternal behavior in pregnant mice and their female offspring. [PDF]

J Vet Med Sci
Our previous reports showed that exposure to the neonicotinoid pesticide clothianidin (CLO) at a no-observed-adverse-effect-level (NOAEL) dose during fetal development and lactation in mice led to higher rates of maternal neglect and infanticide. Although the demonstrated association between decreased oxytocin secretion and decreased maternal parenting
Nunobiki S, Yoshimoto A, Ito M, Yonoichi S, Hara Y, Ishida Y, Morishita R, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Hoshi N.   +11 more
europepmc   +5 more sources

A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in the male rat

Environment International, 2021
Humans carry residues of multiple synthetic chemicals at any given point in time. Research has demonstrated that compounds with varying molecular initiating events (MIE) that disrupt common key events can act in concert to produce cumulative adverse ...
Justin M. Conley, Christy S. Lambright, Nicola Evans, Mary Cardon, Elizabeth Medlock-Kakaley, Vickie S. Wilson, L. Earl Gray, Jr.   +6 more
doaj   +3 more sources

No-observed-adverse-effect-level (NOAEL) clothianidin, a neonicotinoid pesticide, impairs hippocampal memory and motor learning associated with alteration of gene expression in cerebellum. [PDF]

J Vet Med Sci
Neonicotinoid pesticides (NNs) have been associated with numerous neurobehavioral effects in rodents, raising concerns about their impact on cognitive function. Clothianidin (CLO), a type of NN, was orally administered to male mice (10 weeks old, C57BL/6N) at the no-observed-adverse-effect level (NOAEL) of 50 mg/kg/day as indicated in the pesticide ...
Hara Y, Shoda A, Yonoichi S, Ishida Y, Murata M, Kimura M, Ito M, Nunobiki S, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Ikenaka Y, Tabuchi Y, Hoshi N.   +14 more
europepmc   +6 more sources

Effect of chronic T-2 toxin exposure in rabbit bucks, determination of the No Observed Adverse Effect Level (NOAEL) [PDF]

Animal Reproduction Science, 2013
T-2 toxin (T-2) was administered to adult Pannon White (n = 10/group) male rabbits for 65 days, first in a suspension by gavage (0.05, 0.1 or 0.2 mg/animal/day), and secondly mixed into the feed (0.33 and 0.66 mg/kg feed). In the first experiment 0.1 mg T-2 exposure resulted in temporary decrease in feed intake, slower increase in the gonadotropin ...
Melinda Kovács, Zs Matics, Mira Mandoki
exaly   +3 more sources

Interpretation of toxicological research data in establishing the no observed adverse effect level (NOAEL) for medicinal products

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Toxicological studies of new pharmaceuticals in laboratory animals represent an obligatory stage in drug risk assessment, designed to identify toxic effects, their potential reversibility, and dependence on dose and/or systemic exposure ...
K. L. Kryshen, Ya. A. Gushchin, N. M. Faustova, S. V. Gushchina, Zh. Yu. Ustenko, A. E. Katelnikova, K. T. Sultanova, A. A. Matichin, V. A. Vavilova, Ya. G. Murazov, M. V. Miroshnikov, M. A. Kovaleva, D. V. Shubin, V. G. Makarov, M. N. Makarova   +14 more
doaj   +2 more sources

QSAR Models for Repeated Dose Toxicity in Rats Using the CORAL Software [PDF]

Toxics
The evaluation of the safety of chemical substances requires the identification of a safe dose, which has no adverse effects on humans. This is obtained through animal studies, with exposure prolonged for months.
Alla P. Toropova, Andrey A. Toropov, Nadia Iovine, Gianluca Selvestrel, Alessandra Roncaglioni, Emilio Benfenati   +5 more
doaj   +2 more sources

No-observed-Adverse-Effect Level(NOAEL) and Sequential-High-Doses Administration Study on Garcinia cambogia Extract in Humans

Journal of Oleo Science, 2002
(−)-Hydroxycitric acid (HCA), a competitive inhibitor of ATP-citrate lyase, is frequently used in dietary supplements for weight loss in humans, and is the principal acid in the rinds of Garcinia cambogia, a fruit native to Asia. NOAEL (no-observed-adverse-effect level) of G. cambogia extract was determined in the present study and examination was made
Kohsuke Hayamizu, Hiroyuki Shimasaki
exaly   +3 more sources

Physiologically Based Pharmacokinetic Modeling to Predict Human Starting Dose and Pharmacokinetics for Rocbrutinib [PDF]

Clinical and Translational Science
Rocbrutinib is a fourth‐generation Bruton's tyrosine kinase (BTK) inhibitor that covalently binds wild‐type BTK and non‐covalently engages the C481S mutant. Its pharmacokinetic (PK) characteristics in healthy Chinese subjects remain unclear.
Lu Wang, Dandan Yang, Rong Shao, Jinliang Chen, Xiaodan Wang, Zheng Wang, Bo Jiang   +6 more
doaj   +2 more sources

Subchronic safety evaluation of hot-water extract from thinned immature mangos (Mangifera indica ‘Irwin’): 90-days oral toxicity study in rats

Toxicology Reports, 2021
Thinned immature fruit of the mango tree (Mangifera indica ‘Irwin’) are handled as waste. In this study, we conducted a 90-days toxicity study in male and female Sprague Dawley rats to evaluate the safety of a hot-water extract of thinned immature mango ...
Hayato Tajiri, Wataru Tanaka, Masakatsu Takashima, Hiroki Matsuyama, Takuya Sugita, Kenta Hidaka, Hiroyuki Sakakibara   +6 more
doaj   +1 more source

Safety, toxicity and pharmacokinetic assessment of oral Withaferin-A in mice

Toxicology Reports, 2022
Withaferin-A (WA) is the principle component of Withania somnifera (Ashwagandha). It has several biological activities including anti-cancer, anti-diabetic, neuroprotective, hepatoprotective and immune-modulatory properties.
Saurabh Kumar Gupta, Shraddha Jadhav, Dievya Gohil, Girish Ch. Panigrahi, Rajiv Kumar Kaushal, Khushboo Gandhi, Anand Patil, Preeti Chavan, Vikram Gota   +8 more
doaj   +1 more source