Results 1 to 10 of about 972,758 (255)
Hormesis Shifts the No-Observed-Adverse-Effect Level (NOAEL) [PDF]
Dose-Response, 2021 Data from recent dose-response toxicological studies suggest that the no-observed-adverse-effect-level (NOAEL) may depend upon whether hormesis is present. A further examination of these data supports this hypothesis by showing that the NOAEL was greater
Evgenios Agathokleous +2 more
doaj +5 more sources
Determination of No-Observed-Adverse-Effect Level Ammonia in White Mice Through CD4 Expression [PDF]
Dose-Response, 2018 Background: Ammonia is one of the chemical compounds that can cause acute and chronic effects to the workers. The purpose of this study is to determine the no-observed-adverse-effect level (NOAEL) ammonia in white mice.
Abdul Rohim Tualeka +2 more
doaj +5 more sources
Estimating the no-observed-adverse-effect-level (NOAEL) of hormetic dose-response relationships in meta-data evaluations [PDF]
MethodsX, 2021 The number of studies reporting hormetic responses is rapidly increasing, and quantitative evaluations are needed to improve the understanding of hormetic dose responses.
Evgenios Agathokleous +2 more
doaj +2 more sources
Glyphosate below no-observed-adverse-effect level exacerbates fatty liver hemorrhagic syndrome in laying hens [PDF]
Poultry ScienceGlyphosate (GLY) can disturb gut microbiota homeostasis through inhibiting bacterial shikimate pathway to pose a health challenge to animals and humans.
Jingbo Liu +5 more
doaj +2 more sources
Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL) [PDF]
Toxins, 2017 Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
Paula Abal +7 more
doaj +2 more sources
Toxicology Reports, 2021 Diclofenac sodium salt (DSS) is a widely used nonsteroidal anti-inflammatory drug. The present study was performed under good laboratory practice (GLP) regulations to investigate the toxicity of DSS after 4 weeks of repeated intramuscular administration ...
Hyung-Sun Kim +5 more
doaj +1 more source
Toxicology Reports, 2021 Thinned immature fruit of the mango tree (Mangifera indica ‘Irwin’) are handled as waste. In this study, we conducted a 90-days toxicity study in male and female Sprague Dawley rats to evaluate the safety of a hot-water extract of thinned immature mango ...
Hayato Tajiri +6 more
doaj +1 more source
Repeated dose (90 days) oral toxicity study of ursolic acid in Han-Wistar rats
Toxicology Reports, 2020 Background: Ursolic acid (UA) has been used in alternative medicine for decades, and there has been a great interest in its medicinal properties. Despite this increased interest, a detailed long-term toxicity study has not been performed.
Lotte Geerlofs +3 more
doaj +1 more source
Safety, toxicity and pharmacokinetic assessment of oral Withaferin-A in mice
Toxicology Reports, 2022 Withaferin-A (WA) is the principle component of Withania somnifera (Ashwagandha). It has several biological activities including anti-cancer, anti-diabetic, neuroprotective, hepatoprotective and immune-modulatory properties.
Saurabh Kumar Gupta +8 more
doaj +1 more source
Antioxidants, 2021 Chronic kidney disease (CKD) usually causes devastating healthy impacts on patients. However, the causes affecting the decline of kidney function are not fully revealed, especially the involvement of environmental pollutants.
Chia-Fang Wu +5 more
doaj +1 more source