Results 41 to 50 of about 914,178 (235)

Acute and subchronic oral toxicity study of Camelina sativa oil in Wistar rats

Heliyon
Objective: The aim of these studies was to ascertain if Camelina sativa oil is harmful in both the acute and subchronic states. Methods: Wistar rats of both sexes were used in an acute toxicity test, and the fatal dosage (LD50) of oral Camelina sativa ...
Ying Xia, Jie Zhu, Min Qu, Wenxiang Yang, Shaohua Fu, Liqin Yu, Bolin Fan   +6 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Subchronic oral toxicity and in vitro anti-neuroinflammatory evaluation of Ficus erecta leaves extract for potential functional food applications

Toxicology Reports
Ficus erecta leaves, a traditional medicinal plant that is widely used in East Asia, have demonstrated promising cognitive-enhancing effects. However, the safety of its long-term administration has not been elucidated.
Eunjin Sohn, Yu Jin Kim, Woo-Young Jeon, Sae-Rom Yoo, Kyuhyung Jo, Ami Lee, Aejin Kim, Jin Ah Ryuk, Chan-Sik Kim, Bu-Yeo Kim, Mee-Young Lee, Hye-Sun Lim, Youn-Hwan Hwang, Soo-Jin Jeong   +13 more
doaj   +1 more source

26-Week Repeated Dose Oral Toxicity Study of KCHO-1 in Sprague-Dawley Rats

Journal of Pharmacopuncture, 2019
Objectives: KCHO-1(Mecasin), also called Gamijakyakgamchobuja-tang originally, is a combination of some traditional herbal medicines in East Asia. This medicine has been used mainly for alleviating neuropathic pains for centuries in Korean traditional ...
Muhack Yang, Seongjin Lee, Tingting Wang, Eunhye Cha, Jongwon Jang, Dongwoung Kim, Bong-Keun Song, Ilhong Son, Joonyup Kim, Hyung Won Kang, Sungchul Kim   +10 more
doaj   +1 more source

Safety, immunogenicity of lyophilized purified vero cell cultured rabies vaccine administered in Zagreb and Essen regimen in post-exposure subjects: A post-marketing, parallel control clinical trial

Human Vaccines & Immunotherapeutics, 2021
To compare the safety and immunogenicity of lyophilized PVRV under Zagreb and Essen regimen. A post-marketing parallel control clinical trial was conducted.
Lei Zhang, Shichun Huang, Li Cai, Zhenggang Zhu, Jian Chen, Sha Lu, Zerong Zhu, Man Zhang, Yuan Fang, Quan Hu   +9 more
doaj   +1 more source

Dietary administration of β-ionone epoxide to Sprague-Dawley rats for 90 days

Current Research in Toxicology, 2021
In a 90-day GLP-compliant study groups of Sprague-Dawley rats (10/sex/group) were fed diets containing β-ionone epoxide, a fragrance material and a flavoring substance, at dietary concentrations providing target intakes of 0, 20, 40 and 80 mg/kg bw/day ...
Vivian Lu, Maria Bastaki, Anne Marie Api, Michel Aubanel, Mark Bauter, Thierry Cachet, Jan Demyttenaere, Maodo Malick Diop, Christie L. Harman, Shim-mo Hayashi, Gerhard Krammer, Odete Mendes, Kevin J. Renskers, Jürgen Schnabel, Sean V. Taylor   +14 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Assessment of General Toxicity of the Glycyrrhiza New Variety Extract in Rats

Plants, 2021
The Glycyrrhiza radix (Licorice) is one of the most commonly used medicinal plants in Asian countries, such as China, India, and Korea. It has been traditionally used to treat many diseases, including cough, cold, asthma, fatigue, gastritis, and ...
Dong-Gu Kim, Jeonghoon Lee, Wonnam Kim, Hyo-Jin An, Jong-Hyun Lee, Jaeki Chang, Sa-Haeng Kang, Young-Jae Song, Yong-Deok Jeon, Jong-Sik Jin   +9 more
doaj   +1 more source