Results 11 to 20 of about 972,758 (255)

Hypercalcemia and a "no observed adverse effect level" intake of vitamin D. [PDF]

CMAJ, 2019
There are many reasons why the diagnosis of vitamin D toxicity in the recent case report by Auguste and colleagues[1][1] was probably wrong and the result of a red herring. The patient had been taking 8000–10 000 IU of vitamin D daily for 2.5 years, during which time serum creatinine levels ...
Vieth R.
europepmc   +4 more sources

CORAL: model for no observed adverse effect level (NOAEL). [PDF]

Mol Divers, 2015
Abstract The in vivo repeated dose toxicity (RDT) test is intended to provide information on the possible risk caused by repeated exposure to a substance over a limited period of time. The measure of the RDT is the no observed adverse effect level (NOAEL) that is the dose at which no effects are observed, i.e., this endpoint indicates the ...
Toropov AA, Toropova AP, Pizzo F, Lombardo A, Gadaleta D, Benfenati E.   +5 more
europepmc   +4 more sources

A change-point regression approach for estimating no observed adverse effect level from systematic review. [PDF]

J Clin Biochem Nutr, 2023
Systematic reviews can be used not only to evaluate the efficacy and usefulness of a drug or food ingredient, but also as a safety assessment method. One of the aims of safety assessment is to estimate the no observed adverse effect level and the lowest observed adverse effect level.
Kuramochi Y, Hayamizu K.
europepmc   +3 more sources

Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis. [PDF]

J Vet Med Sci
The effects of exposure to clothianidin (CLO), a neonicotinoid pesticide (NN), on the thymus and intestinal microbiota were recently revealed. Immune cells express nicotinic acetylcholine receptors (nAChRs), an NN target, suggesting CLO may disrupt the immune system. However, the relationship between CLO and atopic dermatitis (AD) is unknown.
Ishida Y, Yonoichi S, Hara Y, Shoda A, Kimura M, Murata M, Ito M, Nunobiki S, Yoshimoto A, Mantani Y, Yokoyama T, Hirano T, Matsuo E, Ikenaka Y, Hoshi N.   +14 more
europepmc   +6 more sources

DETERMINING THE NO-OBSERVED-ADVERSE-EFFECT LEVEL IN CATEGORICAL DATA [PDF]

Bulletin of informatics and cybernetics, 1994
Summary: We discuss the determination of the no-observed-adverse-effect level (NOAEL) from categorical data. Recently a method which incorporated the order restriction into the multiple testing was proposed by \textit{K. G. Brown} and \textit{L. S. Erdreich} [Fund. Appl. Toxicology 13, 235-244 (1989)].
Nishiyama, Harutoshi, Yanagawa, Takashi
openaire   +2 more sources

Bisphenol A impairs mitochondrial function in the liver at doses below the no observed adverse effect level. [PDF]

J Korean Med Sci, 2012
Bisphenol A (BPA) has been reported to possess hepatic toxicity. We investigated the hypothesis that BPA, below the no observed adverse effect level (NOAEL), can induce hepatic damage and mitochondrial dysfunction by increasing oxidative stress in the liver. Two doses of BPA, 0.05 and 1.2 mg/kg body weight/day, were administered intraperitoneally for 5
Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, Kim SH, Yoon YC, Cho BJ, Park KS, Jang HC, Park YJ.   +11 more
europepmc   +3 more sources

Effect of imidacloprid on hepatotoxicity and nephrotoxicity in male albino mice

Toxicology Reports, 2014
Imidacloprid (IC) is a systemic insecticide related to the tobacco toxin nicotine. IC is a toxic substance frequently used into combat insects, rodents and plants pests and other creatures that can pose problems for agriculture.
Yasir Arfat, Nasir Mahmood, Muhammad Usman Tahir, Maryam Rashid, Sameer Anjum, Fan Zhao, Di-Jie Li, Yu-Long Sun, Lifang Hu, Chen Zhihao, Chong Yin, Peng Shang, Ai-Rong Qian   +12 more
doaj   +1 more source

Safety Evaluation for Restorin® NMN, a NAD+ Precursor

Frontiers in Pharmacology, 2021
NAD+ is an abundant molecule in the body and vital to all living cells. NAD+ levels decline with age, and this decline correlates with age-related diseases. Therefore, sustaining NAD+ levels offers potential benefits to healthspan and longevity.
John Turner, Albert Licollari, Emil Mihalcea, Aimin Tan   +3 more
doaj   +1 more source

Toxicity and Hypolipidemic Activity of Lansiumamide B in Mice [PDF]

Shipin Kexue
Objective: To explore the hypolipidemic activity and toxic side effect of lansiumamide B (LB) from chicken-heart shaped wampee (Clausena lansium) seeds in C57BL/6J mice fed on a high-fat-diet (HFD) model.
CHEN Danni, WANG Sainan, YIN Zhaochun, XU Zewen, GUO Xiaomin, LI Kangyuan, WANG Jiawei, CHEN Liping, CAO Yong, XIAO Suyao
doaj   +1 more source

The no-observed-adverse-effect level of phthalates promotes proliferation and cell cycle progression in normal human breast cells

Taiwanese Journal of Obstetrics & Gynecology, 2023
Objective: The data on the association between phthalates and breast cancer risk remains inconsistent. This study aimed to explore the possible mechanism of low-dose exposures of phthalates, including Butyl benzyl phthalate (BBP), di(n-butyl) phthalate ...
Fang-Ping Chen, Mei-Hua Chien, Chun-Hui Lee   +2 more
doaj   +1 more source