Results 61 to 70 of about 3,161,134 (287)

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

BMT4me En Español: Multisite Feasibility and Usability Testing of a Spanish‐Language mHealth Adherence Support App for Spanish‐Speaking Caregivers of Children After Hematopoietic Stem Cell Transplantation and Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Medication nonadherence during the first 100 days after pediatric hematopoietic stem cell transplantation (HSCT) and during oncology treatment increases risk for complications. BMT4me is a caregiver‐facing mobile health (mHealth) application providing medication reminders, symptom tracking, and note‐taking features to support ...
Micah A. Skeens, Madeline R. Peek, Bianca Franklin, Emre Sezgin, Melissa Beauchemin   +4 more
wiley   +1 more source

The Caspian Sea level forced by the atmospheric circulation, as observed and modelled [PDF]

, 2007
The Caspian Sea Level (CSL) has experienced large fluctuations with wide-reaching impacts on the population on the coastal regions and on the economy. The CSL variability is dominated by the variability of precipitation over the Volga River basin.
Arpe, K, Leroy, S., Arpe, K., Leroy, S.A.G., Leroy, SAG   +4 more
core  

The use of omics-based approaches in regulatory toxicology: An alternative approach to assess the no observed transcriptional effect level [PDF]

, 2017
The evaluation of chemical hazard is based on the identification of the quality and the quantity of adverse effects as a consequence of exposure.
Morandi, Elena, Marco Villani, VILLANI, Marco, Roli, Andrea, Andrea Roli, Vaccari, Monica, SERRA, Roberto, Polacchini, Laura, Monica Vaccari, Roberto Serra, Rotondo, Francesca, Elena Morandi, Annamaria Colacci, Colacci, Annamaria, Francesca Rotondo, Daniele Quercioli, Laura Polacchini, Quercioli, Daniele, Perdichizzi, Stefania, Stefania Perdichizzi   +19 more
core   +1 more source

Developmental and reproductive toxicity assessment of sporoderm-removed Ganoderma lucidum spores

Frontiers in Cell and Developmental Biology
IntroductionGanoderma lucidum is a fungus used in traditional Chinese medicine with high medicinal value and is also widely used in modern healthcare. Its spores are reported to contain antitumor and anti-inflammatory properties, among other biological ...
Junxiu Liu, Yisheng Song, Yisheng Song, Chuanhuai Chen, Jing Liu, Jing Liu, Siming Zhang, Fang Liu, Fang Liu, Ruiyu Tian, Jinjin Shao, Lili Zhang, Tingli Bian, Ruimin Sun, Li Yu, Shuizhen Pan, Yunxiang Chen, Yaoxian Xuan, Hanbo Wang, Zhenhao Li, Ying Chen, Lijiang Zhang, Lijiang Zhang   +22 more
doaj   +1 more source

Estimating the “First in human” dose – a revisit with particular emphases in oncology drugs

ADMET and DMPK, 2013
The initial dose selection is one of the important steps for any investigative new drug (IND) entering the first clinical study in human. In this mini review, we will discuss the no observed adverse effect level (NOAEL) and the minimum anticipated ...
Kin Tam
doaj   +1 more source

Efficacy of probiotics on stress in healthy volunteers: A systematic review and meta‐analysis based on randomized controlled trials

Brain and Behavior, 2020
Background Probiotics seems to play a beneficial role in stressed populations; thus, a systematic review and meta‐analysis to assess the effects of probiotics on stress in healthy subjects were conducted.
Ning Zhang, Yanan Zhang, Menglin Li, Weiguang Wang, Zhenzhu Liu, Chongcheng Xi, Xunying Huang, Jintao Liu, Junwei Huang, Dong Tian, Jie Mu, Xing Liao, Shuangqing Zhai   +12 more
doaj   +1 more source

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source

Total cucurbitacins from Herpetospermum pedunculosum pericarp do better than Hu-lu-su-pian (HLSP) in its safety and hepatoprotective efficacy

Frontiers in Pharmacology
The pericarp of Herpetospermum pedunculosum (HPP) has traditionally been used for treating jaundice and hepatitis. However, the specific hepatoprotective components and their safety/efficacy profiles remain unclear.
Wen-Ya Liu, Di Xu, Zi-Yun Hu, Hui-Hui Meng, Qi Zheng, Feng-Ye Wu, Xin Feng, Jun-Song Wang   +7 more
doaj   +1 more source

Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease

Toxins, 2019
Microcystins are potent hepatotoxins that have become a global health concern in recent years. Their actions in at-risk populations with pre-existing liver disease is unknown.
Apurva Lad, Robin C. Su, Joshua D. Breidenbach, Paul M. Stemmer, Nicholas J. Carruthers, Nayeli K. Sanchez, Fatimah K. Khalaf, Shungang Zhang, Andrew L. Kleinhenz, Prabhatchandra Dube, Chrysan J. Mohammed, Judy A. Westrick, Erin L. Crawford, Dilrukshika Palagama, David Baliu-Rodriguez, Dragan Isailovic, Bruce Levison, Nikolai Modyanov, Amira F. Gohara, Deepak Malhotra, Steven T. Haller, David J. Kennedy   +21 more
doaj   +1 more source