Results 81 to 90 of about 3,155,563 (287)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

In vitro and in vivo toxicological evaluation of 6′-Sialyllactose sodium salt produced by a novel method

Toxicology Reports
6′-Sialyllactose (6′-SL) sodium salt is the sodium salt of a naturally occurring trisaccharide found in dairy products and human milk. 6′-SL sodium salt formulations produced by different methods have been the subject of other safety studies and are ...
Rit B. Gurung, Laurie C. Dolan, Benjamin G. Arceneaux, Hiroe Go, Eun Jung Park   +4 more
doaj   +1 more source

Proceedings of the Rank Forum on Vitamin D

, 2010
The Rank Forum on Vitamin D was held on 2nd and 3rd July 2009 at the University of Surrey, Guildford, UK. The workshop consisted of a series of scene-setting presentations to address the current issues and challenges concerning vitamin D and health, and ...
Lamberg-Allardt, C, C. Nowson, Martineau, A.R., Miles, LM, Lamberg-Allardt, C., Martineau, AR, Darling, A. L., Macdonald, H M, H. M. Macdonald, Berry, J.L., A. L. Darling, Fraser, WD, S. Reddy, M. Kiely, Darling, A.L., de Groot, CPGM, Macdonald, H. M., C. P. G. M. de Groot, S. A. Lanham-New, Prentice, A., Mavroeidi, A.; id_orcid, de Groot, C P G M, Kiely, M., Stone, E M, Fraser, W. D., Miles, L.M., Macdonald, HM, Lanham-New, S. A., Masud, T, De Groot, C. P.G.M., A. Prentice, Francis, R.M., Vieth, R, Francis, RM, K. D. Cashman, Masud, T., E. Hyppönen, Williams, C. M., Boucher, BJ, de Groot, C.P.G.M., Williams, Christine Mary, Mavroeidi, A., Buttriss, J L, de Groot, C. P. G. M., Boucher, B.J., Mavroeidi, A, Reddy, S., A. Mavroeidi, Nowson, C., Stone, E.M., Cooper, C., W. D. Fraser, Fraser, W D, Cooper, C, A. R. Martineau, Boucher, B. J., Berry, J L, E. M. Stone, Buttriss, J.L., C. Cooper, Francis, R. M., Stone, EM, Williams, CM, Reddy, S, Kiely, K, Kiely, M, Hyppönen, E, T. Masud, Martineau, A. R., Francis, R M, Lanham-New, SA, Vieth, R., C. M. Williams, Hyppönen, E., Prentice, A, Macdonald, H.M., B. J. Boucher, M. Ashwell, Williams, M., J. L. Berry, Ashwell, M., Buttriss, JL, Fraser, W.D., L. M. Miles, Miles, L. M., Nowson, C, Stone, E. M., Cashman, K.D., Lanham-New, S A, C. Lamberg-Allardt, Cashman, K D, Berry, J. L., Berry, J.L, Miles, L M, Cashman, K. D., Ashwell, M, Darling, A L, Buttriss, J. L., J. L. Buttriss, Cashman, KD, de Groot, C.P., R. Vieth, Darling, AL, Williams, C.M., Berry, JL, Lanham-New, S.A., Boucher, B J, Groot, C.P.G.M., de, R. M. Francis, Williams, C M, Martineau, A R, Hypöpnen, E.   +111 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

A 28-day oral toxicology study of an aqueous extract of Polypodium leucotomos (Fernblock®)

Toxicology Reports, 2017
Fernblock® is a standardized commercial aqueous extraction of the leaves of the tropical fern Polypodium leucotomos promoted as an orally active photoprotective substance.
Timothy S. Murbach, Róbert Glávits, Gábor Hirka, John R. Endres, Amy E. Clewell, Ilona Pasics Szakonyiné   +5 more
doaj   +1 more source

Dynamic Adverse Selection and the Size of the Informed Side of the Market [PDF]

In this paper we examine the problem of dynamic adverse selection in a stylized market where the quality of goods is a seller’s private information. We show that in equilibrium all goods can be traded if a simple piece of information is made publicly ...
Ennio Bilancini, Leonardo boncinelli
core