Results 61 to 70 of about 3,738 (206)

A single‐centre analysis of a biosimilar switching programme for adalimumab in inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Aims Amgevita is a licensed biosimilar to adalimumab, having demonstrated high pharmacokinetic and clinical similarity to Humira. Switching to a lower‐cost medicine may elicit a nocebo effect, whereby expectations of poorer efficacy impact outcomes despite pharmacological similarity. This prospective cohort study examined clinical and economic outcomes
Louise Rabbitt, Áine Keogh, Linda Duane, John Ferguson, Anna Hobbins, Brian E. McGuire, Patrick Gillespie, Laurence J. Egan   +7 more
wiley   +1 more source

A new experimental rat model of nocebo‐related nausea involving double mechanisms of observational learning and conditioning

CNS Neuroscience & Therapeutics, 2023
The nocebo effect, such as nausea and vomiting, is one of the major reasons patients discontinue therapy. The underlying mechanisms remain unknown due to a lack of reliable experimental models.
Yu Zhang, Wanbin Huang, Zhengming Shan, Yanjie Zhou, Tao Qiu, Luyu Hu, Liu Yang, Yue Wang, Zheman Xiao   +8 more
semanticscholar   +1 more source

What Physiotherapists Specialized in Orthopedic Manual Therapy Know About Nocebo-Related Effects and Contextual Factors: Findings From a National Survey

Frontiers in Psychology, 2020
ObjectiveThe aim of this study was to investigate the knowledge of orthopedic manual therapists (OMTs) regarding context factors (CFs) capable of triggering nocebo effects during the treatment and how this knowledge is related to their socio-demographic ...
Giacomo Rossettini, Giacomo Rossettini, Tommaso Geri, Alvisa Palese, Chiara Marzaro, Mattia Mirandola, Luana Colloca, Luana Colloca, Mirta Fiorio, Andrea Turolla, Mattia Manoni, Marco Testa   +11 more
doaj   +1 more source

SLCO1B1 Functional Variants, Bilirubin, Statin‐Induced Myotoxicity, and Recent Sub‐Saharan African Ancestry: A Precision Medicine Health Equity Study

Clinical Pharmacology &Therapeutics, EarlyView.
Statin pharmacogenetic implementation guidelines are derived from evidence of primarily Eurocentrically biased study populations. Functional SLCO1B1 variants that are rare in these study populations have not been equitably investigated and are thus missing from guidelines.
Tanushree Haldar, Mark Kvale, Jia Yang, Michael P. Douglas, Willow Coyote‐Maetas, Linda Kachuri, John S. Witte, Carlos Iribarren, Marisa W. Medina, Ronald M. Krauss, Sook Wah Yee, Akinyemi Oni‐Orisan   +11 more
wiley   +1 more source

Placebo and Nocebo Responses in Pharmacological Trials of Tic Disorders: A Meta‐Analysis

Movement Disorders
Clinical trials of new drugs for tic disorders (TD) often fail to yield positive results. Placebo and nocebo responses play a vital role in interpreting the outcomes of randomized controlled trials (RCTs), yet these responses in RCTs of TD remain ...
Simeng Wang, Zhiyi Xiong, Yuehua Cui, Fei Fan, Si Zhang, Ru Jia, Yuchen Hu, Liang Li, Xuan Zhang, Fei Han   +9 more
semanticscholar   +1 more source

The effect of nocebo explanation and empathy on side-effect expectations of medication use following a fictional GP consultation

Psychology, Health & Medicine, 2023
The simple act of informing patients about side-effects increases the likelihood they will experience them (i.e. the nocebo effect). Explaining this psychological phenomenon could help to reduce side-effect experience, however, it is yet to be explored ...
Valentine De Brochowski, G. Rubin, R. Webster   +2 more
semanticscholar   +1 more source

Nocebo response intensity and influencing factors in the randomized clinical trials of irritable bowel syndrome: A systematic review and meta-analysis

Frontiers in Medicine, 2022
ObjectiveTo estimate the magnitude of the nocebo response and explore its influencing factors in irritable bowel syndrome (IBS).MethodsThe PubMed, Embase, and Cochrane Library databases were searched up to March 2021.
Ruijie Li, Fuping Chen, Xuanxuan He, Yuqing Feng, Qiaoqiao Pei, Dongke Wang, Xinghuang Liu, Jinsong Liu, Xiaohua Hou, Tao Bai   +9 more
doaj   +1 more source

Mental Health Impacts of Self‐Help Interventions for the Treatment and Prevention of Eating Disorders. A Meta‐Analysis

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Self‐help programs are recommended as a first step in the management of eating disorders. Yet, whether self‐help interventions have broader mental health benefits beyond symptom and risk reduction remains unclear. As randomized controlled trials (RCTs) also assess general mental health secondary to eating disorder symptoms, we ...
Jake Linardon, Hannah K. Jarman, Claudia Liu, Cleo Anderson, Zoe McClure, Mariel Messer   +5 more
wiley   +1 more source

Nocebo effect in Dermatology

Indian Journal of Dermatology, Venereology, and Leprology, 2015
Nocebo effect, originally denoting the negative counterpart of the placebo phenomenon, is now better defined as the occurrence of adverse effects to a therapeutic intervention because the patient expects them to develop. More commonly encountered in patients with a past negative experience, this effect stems from highly active processes in the central ...
Ankur Srivastava, Kripa Shankar Gupta, Kinshuk Sahaya, Ritu Wadhawan, Sidharth Sonthalia, Rahul Arora, Hamed Zartab, Archana Singal   +7 more
openaire   +3 more sources

Identifying the psychological effects of nocebo education: results from two pre-registered experiments

Journal of behavioral medicine
Providing treatment side effect information to patients increases the risk of harm due to the nocebo effect. Nocebo education, in which patients learn about nocebo effects, is a novel strategy that can be used across a variety of situations and ...
Kim J. Görner, Emily K Spotts, Andrew L. Geers   +2 more
semanticscholar   +1 more source