Results 81 to 90 of about 5,507 (179)

Individual differences in response to repeated painful stimulation: habituation, sensitization, and nocebo effects.

Journal of Pain
The present study analyzes habituation, sensitization, and nocebo effects based on individual differences in response to painful stimulation. Habituation and sensitization to pain show two opposite patterns that may occur during repeated painful ...
Maite M. van der Miesen, Carine J. Vossen, V. N. Compère, E. A. J. Joosten, D. Linden, Judith C. Peters, A. Kaas   +6 more
semanticscholar   +1 more source

“Buprenorphine doesn't hold me”: Neurochemical afterlives of state violence and the struggle for meaning in addiction treatment

Medical Anthropology Quarterly, EarlyView.
Abstract This paper analyzes two disparate experiences of buprenorphine, a medication for opioid addiction, in California. Within the context of the U.S. War on Drugs and after decades of criminalization, buprenorphine represents a shift toward outpatient medical treatment of opioid addiction, but it has been unequally distributed and experienced ...
Lauren Textor
wiley   +1 more source

Nocebo hyperalgesia and the startle response [PDF]

, 2016
Background: The literature on the effects of nocebo on pain is sparse. The present experimental study investigated whether suggestions of nocebo hyperalgesia modified the startle response and whether increased startle contributed to the nocebo ...
Aslaksen, Per M., Øvervoll, Morten, Åsli, Ole, BjØrkedal, espen   +3 more
core   +1 more source

Short‐Term Effect of Negative Verbal Language Versus Positive Verbal Language on Physical and Functional Capacity and Pain in People With Chronic Primary Low Back Pain

European Journal of Pain, Volume 30, Issue 8, September 2026.
ABSTRACT Background Low back pain (LBP) is the leading cause of years lived with disability. While education is recommended by most guidelines, the type of language used can lead to a placebo or nocebo effect. This study aims to compare the short‐term effect of negative language versus positive language on physical and functional capacity in ...
Yves Schwendenmann, Pierre‐Antoine Palacios, Martin Descarreaux, Andrée‐Anne Marchand   +3 more
wiley   +1 more source

Mapping Pain Memory Across Modalities: Distinct Spatial Representations of Recalled Visceral and Somatic Pain

European Journal of Pain, Volume 30, Issue 8, September 2026.
ABSTRACT Background Representation of pain areas offers a spatial dimension of pain perception, yet it has rarely been used in the context of visceral pain. This experimental study examined spatial patterns of acute visceral and somatic pain and their recall.
Catrin Guddat, Genisius Hartanto, Robert J. Pawlik, Thomas Graven‐Nielsen, Sigrid Elsenbruch, Jana L. Aulenkamp   +5 more
wiley   +1 more source

Nocebo Phenomena in Medicine

, 2012
Background: Nocebo phenomena are common in clinical practice and have recently become a popular topic of research and discussion among basic scientists, clinicians, and ethicists.
Ernil Hansen, Paul Enck, Hansen, Ernil, Winfried Häuser, Häuser, Winfried, Enck, Paul   +5 more
core   +1 more source

Cholecystokinin input from the anterior cingulate cortex to the lateral periaqueductal gray mediates nocebo pain behavior in mice

Nature Communications
The nocebo effect, opposite of the better-known placebo effect, in which anticipation of harm worsens pain and other symptoms, is increasingly thought to be responsible for poor clinical outcomes.
Sandra J. Poulson, Aleksandrina Skvortsova, Fatama Tuz Zahra, Damien C. Boorman, Seyed Asaad Karimi, Lisiê V. Paz, Wanning Cui, Antonietta Mandatori, Jacob Burek, Zahra Siddiqi, Maryam I. Fazili, Shivani R. Gami, Oakley B. Morgan, Mélanie Di Maria, Anton Dinh, Lianfang Liang, Robert Contofalsky, Jeffrey S. Mogil, Loren J. Martin   +18 more
doaj   +1 more source

Comparative Effectiveness Analysis of Phase 3 Clinical Trials in Moderately to Severely Active Inflammatory Bowel Disease Reveals Increased Harm From Placebo and Challenges Equipoise

JCC Plus, Volume 1, Issue 5, September 2026.
Across 47 Phase 3 trials in Crohn's disease and ulcerative colitis, placebo exposure was associated with measurable harm. Disease exacerbation events showed the greatest excess risk, with one additional exacerbation occurring for every 8–13 patients assigned to placebo rather than active therapy.
Joëlle St‐Pierre, Zachary D. Fine, Evan N. Fear, Jeremy A. Klein, Natalie K. Choi, David T. Rubin   +5 more
wiley   +1 more source

Optimized communication during risk disclosure to reduce nocebo headache after lumbar puncture—a study protocol for a randomized controlled clinical trial

Frontiers in Psychology
Risk communication has been found to be a driver of nocebo effects in medical settings by enhancing negative expectations. In fact, merely disclosing the risk of side effects and complications of treatments or medical procedures increases reports of ...
Livia Asan, Johanna Sophie Gronen, Lorenz Peters, C. Kleinschnitz, Dagny Holle-Lee, Sven Benson, Ulrike Bingel   +6 more
semanticscholar   +1 more source

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source