Results 61 to 70 of about 2,869 (138)

Direct comparisons of neural activity during placebo analgesia and nocebo hyperalgesia between humans and rats

Communications Biology
Placebo analgesia and nocebo hyperalgesia can profoundly alter pain perception, offering critical implications for pain management. While animal models are increasingly used to explore the underlying mechanisms of these phenomena, it remains unclear ...
Damien C. Boorman, L. Crawford, Luke A. Henderson, Kevin A. Keay   +3 more
semanticscholar   +1 more source

Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications

Experimental Physiology, EarlyView.
Abstract Placebo and nocebo effects on pain provide a model for investigating how cognitive and contextual factors modulate the physiological processes underlying nociception and its regulation. However, existing accounts remain fragmented and lack a unifying mechanistic framework linking brain, behaviour and autonomic responses.
Denisa Adina Zamfira, Tommaso Fassina, Kamil Zaworski, Elisa Carlino, Giacomo Rossettini   +4 more
wiley   +1 more source

Fear of pain potentiates nocebo hyperalgesia

Journal of Pain Research, 2015
Per M Aslaksen,1 Peter S Lyby2 1Department of Psychology, Research Group for Cognitive Neuroscience, The Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway; 2Catosenteret Rehabilitation Center,
Aslaksen PM, Lyby PS
doaj  

Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses. [PDF]

PLoS ONE, 2014
A large number of unwanted adverse events and symptoms reported by patients in clinical trials are not caused by the drug provided, since most of adverse events also occur in corresponding placebo groups.
Laura Wendt, Antje Albring, Sven Benson, Harald Engler, Andrea Engler, Anke Hinney, Winfried Rief, Oliver Witzke, Manfred Schedlowski   +8 more
doaj   +1 more source

Chicken or egg? Attribution hypothesis and nocebo hypothesis to explain somatization associated to perceived RF-EMF exposure

Frontiers in Public Health
Introduction The aim of this study is to understand the temporal relationship between the somatization usually attributed to RF-EMFs, and to evaluate the attribution hypothesis and the nocebo hypothesis in this context. Method In this longitudinal study,
S. Ariccio, E. Traini, L. Portengen, A. Martens, P. Slottje, R. Vermeulen, A. Huss   +6 more
semanticscholar   +1 more source

Individual difference factors that predict evaluations and acceptance of authorized concealment for the reduction of nocebo side effects.

Patient Education and Counseling
OBJECTIVES Authorized concealment is a shared decision-making technique in which a clinician asks a patient if they would prefer not to be informed about all possible treatment side effects, so as to minimize nocebo effects. The present research assessed
Emily K. Spotts, Franklin G. Miller, Andrew L. Geers   +2 more
semanticscholar   +1 more source

Resisting Contagious Hopelessness: Therapeutic Alliance and the Limits of Physician‐Assisted Death in Severe and Enduring Anorexia Nervosa

Psychiatric Research and Clinical Practice, EarlyView.
Contemporary psychiatric ethics emphasize autonomy and shared decision‐making, yet these frameworks may be strained in severe mental illnesses characterized by cognitive rigidity, fluctuating decisional capacity, and undue clinician influence. Severe and enduring anorexia nervosa serves as a case example to explore how therapeutic alliance, clinician ...
Elizabeth M. Olson, Fabian M. Saleh, Angela S. Guarda   +2 more
wiley   +1 more source

Moderators of nocebo effects in controlled experiments: A multi-level meta-analysis.

Neuroscience and Biobehavioral Reviews
Nocebo effects are a heterogenous phenomenon in which contextual cues trigger or exacerbate symptoms independently of active interventions. Suggestion, conditioning, and social observation are widely recognised as hallmark methods for inducing nocebo ...
M. V. Stein, Monika Heller, Natasha Hughes, Danielle Marr, Benjamin Brake, S. Chapman, G. J. Rubin, D. Terhune   +7 more
semanticscholar   +1 more source

Dispositional optimism and open‐label placebo responses in hair cortisol concentrations and psychological distress—A randomized controlled trial

Applied Psychology: Health and Well-Being, Volume 18, Issue 5, October 2026.
Abstract Open‐label placebo (OLP) treatments show beneficial effects on various health‐related outcomes, but studies investigating OLP effects on physiological measures remain scarce. This randomized controlled trial examined the effect of a 4‐week OLP intervention on psychological distress and hair cortisol concentrations (HCC) in 202 healthy ...
Carolin Liedtke, Michael Schaefer, Sören Enge   +2 more
wiley   +1 more source

Clinical neuroscience and neurobiology of placebo and nocebo effects

International review of neurobiology
Placebo effects refer to changes in outcomes driven by learning and expectations, and they can shape responses to both pharmacologic and non-pharmacologic interventions.
N. Raghuraman, Luana Colloca
semanticscholar   +1 more source