Results 61 to 70 of about 4,447 (179)

Peripheral Inflammation and Sleep Loss Induce Coordinated Motivational Changes: An Experimental Two‐Hit Stress Model

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep loss and low‐grade inflammation are common stressors that affect behaviour and recovery needs. To examine their separate and combined effects on motivation for everyday behaviours, we developed a two‐hit experimental model. Participants (N = 56, 31 women) completed three experimental visits: sleep saturation (two nights, 9 h in bed/night)
John Axelsson, Mats Lekander, Camilla I. Svensson, Nils Simon, Alexandra Kuliszkiewicz, Julie Lasselin, Leonie J. T. Balter   +6 more
wiley   +1 more source

Placebo and Nocebo Effects Across Symptoms: From Pain to Fatigue, Dyspnea, Nausea, and Itch

Frontiers in Psychiatry, 2019
Placebo and nocebo effects are, respectively, the helpful and harmful treatment effects that do not arise from active treatment components. These effects have thus far been researched most often in pain.
Fabian Wolters, Fabian Wolters, Kaya J. Peerdeman, Kaya J. Peerdeman, Andrea W.M. Evers, Andrea W.M. Evers, Andrea W.M. Evers   +6 more
doaj   +1 more source

Nocebo response intensity and influencing factors in the randomized clinical trials of irritable bowel syndrome: A systematic review and meta-analysis

Frontiers in Medicine, 2022
ObjectiveTo estimate the magnitude of the nocebo response and explore its influencing factors in irritable bowel syndrome (IBS).MethodsThe PubMed, Embase, and Cochrane Library databases were searched up to March 2021.
Ruijie Li, Fuping Chen, Xuanxuan He, Yuqing Feng, Qiaoqiao Pei, Dongke Wang, Xinghuang Liu, Jinsong Liu, Xiaohua Hou, Tao Bai   +9 more
doaj   +1 more source

Ischaemic pre‐conditioning improves workload, fatigue and recovery in team sport: A randomized, double‐blind, placebo‐controlled crossover trial

Experimental Physiology, EarlyView.
Abstract Ischaemic preconditioning (IPC) is reported to improve performance, fatigue and recovery, yet evidence in team‐sport settings remains limited. We examined the effects of repeated IPC on external workload, perceptual strain and recovery during ecologically valid Gaelic football training.
Lorcan Daly, Shane Farrell, Alexander Gamble   +2 more
wiley   +1 more source

Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses. [PDF]

PLoS ONE, 2014
A large number of unwanted adverse events and symptoms reported by patients in clinical trials are not caused by the drug provided, since most of adverse events also occur in corresponding placebo groups.
Laura Wendt, Antje Albring, Sven Benson, Harald Engler, Andrea Engler, Anke Hinney, Winfried Rief, Oliver Witzke, Manfred Schedlowski   +8 more
doaj   +1 more source

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

Fear of pain potentiates nocebo hyperalgesia

Journal of Pain Research, 2015
Per M Aslaksen,1 Peter S Lyby2 1Department of Psychology, Research Group for Cognitive Neuroscience, The Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway; 2Catosenteret Rehabilitation Center,
Aslaksen PM, Lyby PS
doaj  

Placebo and nocebo effects

Pain
Abstract We introduce the Psychoneurobiology, Individualization, and Normalization (PIN) framework of placebo and nocebo effects. Traditionally, research primarily focused on psychoneurobiological mechanisms of these effects, the Psychoneurobiology phase.
Belina Rodrigues, Nandini Raghuraman, Roni Shafir, Yang Wang, Lakota Watson, James Cottam, Mumtahana Nabi, Titilola Akintola, Luana Colloca   +8 more
openaire   +2 more sources

Financial Toxicity Associated with Biological Medicines: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 81-93, July 2026.
Financial toxicity, defined as the economic burden experienced by patients due to medication and other healthcare costs and their consequences, such as material, psychosocial and behavioral effects, represents a significant concern for individuals receiving biological medicines.
Laura Sara Maria Saarukka, Kamilla Yamileva, Kari Linden, Anniina Simonen, Anna‐Riia Holmström   +4 more
wiley   +1 more source

Expectations and Motivations for Participation in Clinical Trials Utilizing Psychedelics for Treatment‐Resistant Depression: A Qualitative Study

Brain and Behavior, Volume 16, Issue 6, June 2026.
Individuals with treatment‐resistant depression considering psychedelic trial participation were motivated by chronic illness, failed treatments, and hope for a novel intervention, while actively minimizing expectations to guard against disappointment.
Christopher Poppe, Liisa Lyck, Laura Bechtold, Dimitris Repantis   +3 more
wiley   +1 more source