Results 31 to 40 of about 15,370 (68)

How the magnitude and precision of pain predictions shape pain experiences

European Journal of Pain, Volume 29, Issue 1, January 2025.
Abstract Background In Bayesian models including predictive processing, the magnitude and precision of pain expectancies are key determinants of perception. However, relatively few studies have directly tested whether this holds for pain, and results so far have been inconclusive.
Suzanne M. J. C. Derksen, Maria Konttinen, Anastasiia Myronenko, Ben Seymour, Kaya J. Peerdeman   +4 more
wiley   +1 more source

As different as fear and anxiety : introducing the fear and anxiety model of placebo hypoalgesia and nocebo hyperalgesia [PDF]

Research suggests that negative affective states, such as fear and anxiety that accompany placebo treatment may be considered predictors of placebo hypoalgesia and nocebo hyperalgesia.
Rubanets, Daryna, Bąbel, Przemysław, Honcharova, Sofiia, Badzińska, Julia, Bajcar, Elżbieta   +4 more
core   +1 more source

The influence of pre-treatment state anxiety on the magnitude of nocebo hyperalgesia

, 2023
The current project aims to examine the influence of increased pre-treatment state anxiety on nocebo hyperalgesia shaped by classical ...
Pain Research Group
core   +1 more source

Topically applied novel TRPV1 receptor antagonist, ACD440 Gel, reduces evoked pain in healthy volunteers, a randomized, double‐blind, placebo‐controlled, crossover study

European Journal of Pain, Volume 28, Issue 10, Page 1656-1673, November 2024.
Abstract Background The TRPV1 receptor is a key molecule in pain generation. Previous development of oral TRPV1‐antagonists was halted due to systemic heat insensitivity and body temperature alterations. The present Phase 1b study investigated the efficacy, safety and plasma exposure of a topically administered TRPV1‐antagonist (ACD440 Gel) in healthy ...
M. Segerdahl, M. Rother, M. M. Halldin, T. Popescu, K. Schaffler   +4 more
wiley   +1 more source

Too anxious to learn: Induced state anxiety prevents the formation of nocebo hyperalgesia

Nocebo hyperalgesia is characterized by a pain increase following an inactive intervention. Existing research on the mechanisms of nocebo effects has predominantly centered around the role of cognitive processes, leaving emotional processes relatively ...
Elżbieta A. Bajcar, Daryna Rubanets, Przemysław Bąbel   +2 more
core   +1 more source

Peri‐operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society

Anaesthesia, Volume 79, Issue 11, Page 1220-1236, November 2024.
Summary Background Nearly half of adult patients undergoing surgery experience moderate or severe postoperative pain. Inadequate pain management hampers postoperative recovery and function and may be associated with adverse outcomes. This multidisciplinary consensus statement provides principles that might aid postoperative recovery, and which should ...
Kariem El‐Boghdadly, Nicholas A. Levy, William J. Fawcett, Roger D. Knaggs, Helen Laycock, Emma Baird, Felicia J. Cox, Will Eardley, Harriet Kemp, Zoey Malpus, Andrea Partridge, Judith Partridge, Anjna Patel, Cathy Price, Joyce Robinson, Kim Russon, Jackie Walumbe, Dileep N. Lobo   +17 more
wiley   +1 more source

Nocebo hyperalgesia and pain progression: prediction, acquisition, and recovery [PDF]

Nocebo effects are adverse treatment outcomes that cannot be attributed to active treatment components. A common example is the experiencing of side effects after reading the side effect description on a medication leaflet.
Karacaoglu, M.
core  

Pain rating is worth a thousand words. Nocebo hyperalgesia induced by verbal modeling prevails over the effects of symbolic modeling and verbal suggestion

, 2023
This study compares the effectiveness of verbal modeling, symbolic modeling, and verbal suggestion in inducing nocebo hyperalgesia. It is the first study to examine the contribution of stress to observationally induced nocebo hyperalgesia.
Joanna Kłosowska, Elżbieta A. Bajcar, Daryna Rubanets, Julia Badzińska, Przemysław Bąbel   +4 more
core   +1 more source

Placebo hypoalgesia and nocebo hyperalgesia induced by observational learning may be difficult to disentangle in a laboratory setting

, 2022
Observational learning (OBL) can evoke placebo hypoalgesia and nocebo hyperalgesia, however, these effects have rarely been systematically compared. Healthy participants (n=105) were randomised to: 1) placebo OBL, 2) nocebo OBL, or 3) a no-observation ...
Joanna Kłosowska, Elżbieta A. Bajcar, Stefanie Meeuwis, Mateusz Wasylewski, Julia Badzińska, Daryna Rubanets, Marianna Di Nardo, Przemysław Bąbel, Giuliana Mazzoni   +8 more
core   +1 more source

Dodo bird verdict: Verbal modeling, counterconditioning, and operant conditioning are effective in nocebo hyperalgesia attenuation

Nocebo hyperalgesia, the increased pain following inert interventions, is frequently observed in clinical practice. The limited research has focused on methods of attenuating this effect.
Rubanets, Daryna, Joanna Kłosowska, Elżbieta A. Bajcar, Kłosowska, Joanna, Bąbel, Przemysław, Łaska, Izabela Anna, Daryna Rubanets, Izabela Łaska, Przemysław Bąbel, Bajcar, Elżbieta Anita   +9 more
core   +1 more source