The role of self-reported and physiological stress in nocebo hyperalgesia.
, 2023 Negative expectations can increase pain sensitivity, leading to nocebo hyperalgesia. However, the physiological and psychological factors that predispose individuals to this phenomenon are still not well understood.
Stefanie Meeuwis +1 more
core +2 more sources
The effect of psychological manipulations on the development of secondary hyperalgesia: a critical review [PDF]
PAIN Reports. As central sensitization is believed to contribute to persistent pain and psychological factors are increasingly acknowledged to play a role as well, the question arises of whether psychological factors can modulate the development of central ...
Elke Meyers +3 more
doaj +2 more sources
Nocebo effects are stronger and more persistent than placebo effects in healthy individuals [PDF]
eLifePlacebo and nocebo effects illustrate the profound influence of cognitive-affective processes on symptom perception and treatment outcomes, with the potential to significantly alter responses to medical interventions.
Angelika Kunkel +6 more
doaj +2 more sources
Nocebo Hyperalgesia can be Induced by the Observation of a Model Showing Natural Pain Expressions
The Clinical Journal of Pain, 2019 OBJECTIVES Nocebo hyperalgesia is an increase in pain through the expectation of such an increase as a consequence of a sham treatment. Nocebo hyperalgesia can be induced by observation of a model demonstrating increased pain via verbal pain ratings ...
Vögtle, Elisabeth +5 more
core +5 more sources
When do placebo and nocebo work? The role of time on placebo analgesia and nocebo hyperalgesia.
, 2021 Verbal suggestions are strong modulators of one’s expectations and they can be used to induce placebo and nocebo responses. Research so far has investigated the magnitude (i.e. stronger or weaker) and the direction (i.e.
CAMERONE, ELEONORA MARIA
core +3 more sources
Learning mechanisms in nocebo hyperalgesia: the role of conditioning and extinction processes. [PDF]
Pain, 2020 Abstract Nocebo hyperalgesia is a clinically relevant phenomenon and may be formed as a result of associative learning, implemented by classical conditioning. This study explored for the first time distinct nocebo conditioning methods and their consequences for nocebo attenuation methods.
Thomaidou MA +5 more
europepmc +6 more sources
Exploring the role of negative expectations and emotions in primary dysmenorrhea: insights from a case-control study [PDF]
BMC Women's HealthBackground Primary dysmenorrhea, characterized by painful menstruation, significantly impacts the quality of life for women worldwide. Negative expectations and associated emotions are known to trigger nocebo effects and may also influence cyclic ...
Verena Thomann +4 more
doaj +2 more sources
Order does matter: the combined effects of classical conditioning and verbal suggestions on placebo hypoalgesia and nocebo hyperalgesia. [PDF]
Pain, 2021 In most experimental studies in which verbal suggestion and classical conditioning are implemented together to induce placebo effects, the former precedesthe latter.
Bajcar EA +5 more
europepmc +2 more sources
A Comprehensive Scientometric Analysis of Placebo and Nocebo Effects in Pain Research: From Placebo Mechanisms to Clinical Trials. [PDF]
J Eval Clin PractABSTRACT Placebo and nocebo phenomena are central in neuroscience, psychology, and clinical research, yet comprehensive bibliometric analyses remain limited. This study mapped placebo and nocebo research in pain, distinguishing mechanistic studies from randomised controlled trials (RCTs), using data from the Web of Science Core Collection up to March ...
Borghesi F +7 more
europepmc +2 more sources
Scientific Reports, 2022 Learning and negative outcome expectations can increase pain sensitivity, a phenomenon known as nocebo hyperalgesia. Here, we examined how a targeted pharmacological manipulation of learning would impact nocebo responses and their brain correlates ...
Mia A. Thomaidou +7 more
doaj +1 more source