Results 191 to 200 of about 7,926,126 (218)

Nocebo responses in randomized controlled trials of COVID-19 vaccines

Int. Journal of Clinical Pharmacology and Therapeutics, 2022
The aim of this study was to evaluate the frequency and magnitude of nocebo responses in -COVID-19 vaccine trials.We performed a meta-analysis of adverse effects (AEs), severe adverse effects (SAEs), withdrawal due to AEs, death, and immune-mediated SAEs observed in randomized controlled trials (RCTs) of COVID-19 vaccines.Four RCTs with a total of 119 ...
Young Ho Lee, Gwan Gyu Song
openaire   +3 more sources

Placebo and nocebo response magnitude on temporomandibular disorders related-pain: a systematic review and meta-analysis.

Journal of Oral Rehabilitation, 2019
OBJECTIVES The aim of this systematic review (SR) was to answer the following question: "In adult patients with temporomandibular disorders (TMD) related-pain, what is the placebo or nocebo effect of different therapies?" METHODS A SR was performed ...
A. Porporatti, Y. Costa, J. C. Réus, J. Stuginski‐Barbosa, P. Conti, A. Velly, G. De Luca Canto   +6 more
semanticscholar   +1 more source

Placebo and Nocebo Responses, Cortisol, and Circulating Beta-Endorphin

Psychosomatic Medicine, 2003
The experiment tested whether the placebo and nocebo responses could be mediated via modulation of stress.Ischemic pain was induced in healthy volunteers (N = 59). When pain reached "7" on a 10-point scale, two groups of subjects received information that a pain relieving (the Placebo group) or a pain increasing (the Nocebo group) substance was ...
Jan Brox, Magne Arve Flaten, Oddmund Johansen   +2 more
openaire   +3 more sources

Metaforest Algorithm Insights: Predictors of Nocebo Response in ADHD

Current Psychopharmacology
Predicting the nocebo response in randomized controlled trials (RCTs) is crucial as it can help minimize its influence and improve the evaluation of the side effects of interventions for ADHD.
Mireia Porta, Maggie Barcheni, David Ramírez-Saco, R. Cunill, M. Farré, Marc Saez, Beatriz López, Xavier Castells   +7 more
semanticscholar   +1 more source

Mechanisms Involved in Placebo and Nocebo Responses and Implications for Drug Trials

Clinical Pharmacology & Therapeutics, 2011
Drug trials often compare active drugs with inert placebos under double-blind conditions. This standard design is increasingly being questioned in light of recent progress in understanding the mechanisms behind the placebo response.1,2 The growing knowledge of the neurobiology of placebo is forcing us to reconsider the significance of the placebo in ...
Rief, W., Bingel, Ulrike, Schedlowski, Manfred, Enck, P.   +3 more
openaire   +3 more sources

Is there a nocebo response that results from disease awareness campaigns and advertising in Australia, and can this effect be mitigated?

Journal of Medical Ethics, 2018
Direct-to-consumer advertising is banned in Australia, and instead pharmaceutical companies use disease awareness campaigns as a strategy to raise public awareness of conditions for which the company produces a treatment. This practice has been justified
Stuart Benson, D. Hunter
semanticscholar   +1 more source

Nocebo effect as the opposite of the placebo effect: Systematic review

Seminars in Medical Writing and Education, 2023
Background: The placebo effect refers to a clinical improvement in a patient as a result of interactions with the treating physician, information received about the treatment, and the defined therapy. The placebo effect is a broad field involving complex
Viviani França Drissen, Analía Claudia Sabattini   +1 more
semanticscholar   +1 more source

Drug-Related Information Generates Placebo and Nocebo Responses That Modify the Drug Response

Psychosomatic Medicine, 1999
Administration of the muscle relaxant carisoprodol and placebo was crossed with information that was agonistic or antagonistic to the effect of carisoprodol. It was investigated whether information alone induced physiological and psychological responses, and whether information modified the response to the drug.Half of the subjects received capsules ...
Terje Simonsen, Magne Arve Flaten, Harald Olsen   +2 more
openaire   +3 more sources

Nocebo Responses in Brain Diseases: A Systematic Review of the Current Literature

2018
Placebo is an intervention with no therapeutic effect that is used as a control in randomized controlled trials (RCTs). Placebo effects and responses can produce a beneficial effect that cannot be attributed to the properties of the intervention itself, since it is usually inactive, and should, therefore, be due to the patient's expectations about ...
Zis, Panagiotis, Mitsikostas, Dimos-Dimitrios, Zis, Panagiotis, Mitsikostas, Dimos-Dimitrios   +3 more
openaire   +4 more sources

Mind games in dentistry: confounded evidence suggests a substantial nocebo response in dental impaction pain model.

Evidence-Based Dentistry, 2023
Omer Waleed Majid
semanticscholar   +1 more source