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Incidence and characteristics of the nocebo response from meta‐analyses of the placebo arms of clinical trials of olanzapine for bipolar disorder [PDF]
Bipolar Disorders, 2019 OBJECTIVES: In the clinical setting, the nocebo phenomenon is where clinical worsening or adverse events occur as a response to a treatment, in a situation in which conditioning from previous treatment exposure and/or expectations of sickness or symptoms
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Nocebo responses in randomized controlled trials of COVID-19 vaccines
Int. Journal of Clinical Pharmacology and Therapeutics, 2022The aim of this study was to evaluate the frequency and magnitude of nocebo responses in -COVID-19 vaccine trials.We performed a meta-analysis of adverse effects (AEs), severe adverse effects (SAEs), withdrawal due to AEs, death, and immune-mediated SAEs observed in randomized controlled trials (RCTs) of COVID-19 vaccines.Four RCTs with a total of 119 ...
Young Ho, Lee, Gwan Gyu, Song
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Placebo and Nocebo Responses, Cortisol, and Circulating Beta-Endorphin
Psychosomatic Medicine, 2003The experiment tested whether the placebo and nocebo responses could be mediated via modulation of stress.Ischemic pain was induced in healthy volunteers (N = 59). When pain reached "7" on a 10-point scale, two groups of subjects received information that a pain relieving (the Placebo group) or a pain increasing (the Nocebo group) substance was ...
Oddmund, Johansen +2 more
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Nonmaleficence, Nondisclosure, and Nocebo: Response to Open Peer Commentaries
The American Journal of Bioethics, 2017In our target article, “When Respecting Autonomy Is Harmful: A Clinically Relevant Approach to the Nocebo Effect,” we advocate for selective nondisclosure of medication-related side effects based o...
John T. Fortunato +2 more
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Mechanisms Involved in Placebo and Nocebo Responses and Implications for Drug Trials
Clinical Pharmacology & Therapeutics, 2011Drug trials often compare active drugs with inert placebos under double-blind conditions. This standard design is increasingly being questioned in light of recent progress in understanding the mechanisms behind the placebo response.1,2 The growing knowledge of the neurobiology of placebo is forcing us to reconsider the significance of the placebo in ...
Rief, W. +3 more
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Drug-Related Information Generates Placebo and Nocebo Responses That Modify the Drug Response
Psychosomatic Medicine, 1999Administration of the muscle relaxant carisoprodol and placebo was crossed with information that was agonistic or antagonistic to the effect of carisoprodol. It was investigated whether information alone induced physiological and psychological responses, and whether information modified the response to the drug.Half of the subjects received capsules ...
M A, Flaten, T, Simonsen, H, Olsen
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Nocebo response: individual differences, network structure, and heterogeneity
2022Nocebo effects have been well documented throughout the health and medical literature and are defined as the worsening of symptoms due to prior beliefs, negative-health information or suggestion (Colloca et al., 2020, New England Journal of Medicine).
Cottam, Martha, Terhune, Devin
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Placebo and nocebo responses in painful diabetic neuropathy: systematic review and meta-analysis
Pain, 2023Abstract This preregistered (CRD42021223379) systematic review and meta-analysis aimed to characterize the placebo and nocebo responses in placebo-controlled randomized clinical trials (RCTs) on painful diabetic neuropathy (PDN), updating the previous literature by a decade. Four databases were searched for PDN trials published in the past 20
Elisa Frisaldi +4 more
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What influences placebo and nocebo responses in Parkinson's disease?
Movement Disorders, 2018AbstractPlacebo treatment is associated with clinical improvements in many medical conditions, but is particularly important in Parkinson's disease because improvements are common, marked, and associated with objective neurochemical and neurophysiologic changes.
Natalie, Witek +2 more
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The placebo and nocebo responses in patients with epilepsy
2015Placebo and nocebo responses in epilepsy have been mainlyinvestigated by meta-analytic approaches aimed to evaluate the extent ofsuch phenomenon in randomized, controlled, clinical trials. These studiesreported placebo response rates (defined as proportion of patients with =50% improvement of seizures compared to baseline observations) rangingfrom 9.9%
Giovannelli F. +2 more
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