Results 211 to 220 of about 88,386 (325)

Antinociceptive effect of Arvelexin in male mouse models. [PDF]

Sci Rep
Bseiso Y, Gammoh O, Qnais E, Barakat M, Oqal M, Abudalo R, Alotaibi BS, Aljabali AAA, Alzaghari LF, Alqudah A.   +9 more
europepmc   +1 more source

Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain

British Journal of Pharmacology, Volume 183, Issue 9, Page 2009-2027, May 2026.
Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho, Raquel Tonello, Evelyne Silva Brum, Gabriela Becker, Nigel W. Bunnett, Sara Marchesan Oliveira   +5 more
wiley   +1 more source

Nociception level index as a tool of measuring pain objectively in patients with complex regional pain syndrome: a feasibility study. [PDF]

Front Pain Res (Lausanne)
Umar I, Tenenbaum A, Tzour A, Khalaia A, Grach M.   +4 more
europepmc   +1 more source

TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction.

Neuron, 2006
Kelvin Y. Kwan, A. Allchorne, M. Vollrath, Adam P. Christensen, Duan-Sun Zhang, C. Woolf, D. Corey   +6 more
semanticscholar   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, Volume 183, Issue 10, Page 2307-2323, May 2026.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Assessment of Nociception and Inflammatory/Tissue Damage Biomarkers in a Post-COVID-19 Animal Model. [PDF]

Int J Mol Sci
Sánchez-Robles EM, Rodríguez-Rivera C, Paniagua Lora N, Herradón Pliego E, Goicoechea Garcia C, Arendt-Nielsen L, Fernández-de-Las-Peñas C, López-Miranda V.   +7 more
europepmc   +1 more source

Clinical characterization of thoracolumbar and lumbar intervertebral disk extrusions in English Cocker Spaniels [PDF]

, 2016
Aikawa T, Braund KG, Brown NO, Caitlin E. Tzounos, Dewey CW, Goggin JE, Holger A. Volk, Mogensen MS, Ruddle TL, Steven De Decker, Thomas J.A. Cardy   +10 more
core   +2 more sources

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2324-2340, May 2026.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Review: spinal shock, crossed extensor reflex, and mass reflex in dogs and cats-a literature review, clinical observations and considerations. [PDF]

Front Vet Sci
Santifort KM, Polidoro D, Hermans M, Olszewska A, Kaczmarska A, Poli F, Bongers J.   +6 more
europepmc   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source