Results 221 to 230 of about 86,806 (345)

Nalfurafine is Aversive at Antinociceptive Doses in Mice

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
ABSTRACT Nalfurafine is the only clinically approved kappa opioid receptor (KOPr) agonist that can cross the blood–brain barrier and exert CNS effects. Because its clinical use is not associated with dysphoria, it is widely believed to have an atypical pharmacological profile.
E. J. Kuijer, L. H. Marinelli, S. J. Bailey, D. J. Heal, S. Smith, S. Wonnacott, C. P. Bailey   +6 more
wiley   +1 more source

Use of a rectus sheath block to provide successful perioperative analgesia for umbilical hernia repair in a Boer goat (Capra aegagrus hircus)

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract Providing perioperative analgesia in farm animal species is often hampered by limited analgesic agent availability, legal restrictions, or an absence of licensed products. A 38.7 kg, 6‐month‐old male Boer goat presented for surgical repair of a non‐strangulated umbilical hernia.
Nadiah Syuhada Roslan, Shurim Nazwar Mahamarowi, Mimi Armiladiana Mohamad, Daniel S. J. Pang   +3 more
wiley   +1 more source

Comparison of Opioid Consumption During Target Controlled Infusion (TCI) Guided By Nociception Level Index (NOL) or Standard Care Undergoing Intracranial Tumor Surgery. [PDF]

J Pain Res
Demirel ME, Bilgin H, Akesen S.
europepmc   +1 more source

Hot and Cold Nociception Are Genetically Correlated [PDF]

, 1999
Jeffrey S. Mogil, Seetal M. Adhikari
openalex   +1 more source

Effects of methotrexate on Wnt/β‐catenin signaling and glial activation in temporomandibular joint arthritis in rats

European Journal of Oral Sciences, Volume 133, Issue 6, December 2025.
Abstract Rheumatoid arthritis is a chronic autoimmune disease that can affect the temporomandibular joint (TMJ) and cause pain. Methotrexate is widely used to control disease progression, but its effects on pain mechanisms are not fully understood. This study evaluated the antinociceptive effects of methotrexate on pain behavior, Wnt/β‐catenin pathway ...
Ana Carolina de Figueiredo Costa, Luane Macedo de Sousa, Sofia Tavares Bessa, Anamaria Falcão Pereira, Paula Goes, Mariana Lima Vale, Delane Viana Gondim   +6 more
wiley   +1 more source

qNOX index for quantification of intraoperative nociception and analgesia. Comment on Br J Anaesth 2025; 134: 736-45. [PDF]

Br J Anaesth
Barroso A, Aragón-Benedí C.
europepmc   +1 more source

Capsaicin-szenzitív neurogén mechanizmusok a meningeális nocicepcióban és a dura mater vaszkuláris reakcióinak modulációjában = Role of capsaicin-sensitive neurogenic mechanisms in meningeal nociception and in the modulation of vascular reactions of the dura mater [PDF]

, 2010
Gábor Jancsó, Mária Dux, Péter Sántha, Krisztina Boros, Dorina Tóth   +4 more
openalex  

Analysis of the Effects of Epidural Anesthesia on the Nociception Level Index (NOL®) during Abdominal Surgery [PDF]

Alexander Ziebart, David-Jonas Rothgerber, Sophia Woldt, Katharina Mackert, J. Heiden, Michael Schuster, Jens Kamuf, Eva‐Verena Griemert, Robert Ruemmler   +8 more
openalex   +1 more source

Mechanisms of microbial–neuronal interactions in pain and nociception

Neurobiology of Pain, 2020
Valentina N. Lagomarsino, A. Kostic, I. Chiu   +2 more
semanticscholar   +1 more source

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

The FEBS Journal, Volume 292, Issue 23, Page 6365-6399, December 2025.
GLE1 plays a direct role mRNA regulation, translation, and formation of cytosolic stress granules. GLE1 dysfunction has been associated with devastating diseases, including lethal congenital contracture syndrome 1(LCCS1), a rare disorder enriched in isolated populations.
Tomáš Zárybnický, Sonja Lindfors, Saana Metso, Julia Koivula, Zoltan Szabo, Rasmus Valtonen, Mikko Tulppo, Johanna Magga, Samu Saarimäki, Sonja Bläuer, Ilkka Miinalainen, Risto Kerkelä, Petteri. T. Piepponen, Vootele Voikar, Juho Väänänen, Riikka Kivelä, Bhagwan Yadav, Hanna Lindgren, Pirkko Mattila, Fu‐Ping Zhang, Petra Sipilä, Reetta Hinttala, Satu Kuure   +22 more
wiley   +1 more source