Results 181 to 190 of about 89,362 (300)

EEG FREQUENCY-TAGGING TO DETERMINE WHETHER THE CORTICAL PROCESSING OF NOCICEPTIVE AND NON-NOCICEPTIVE SOMATOSENSORY INPUT INVOLVES DISTINCT NEURONAL POPULATIONS.

, 2013
Whether the cortical processing of nociceptive input relies on the activity of nociceptive-specific neurons or whether it relies on the activity of non-specific neuronal populations remains a matter of intense debate. Here, we address this question using
Colon, Elisabeth, Neural Circuits of Pain, Legrain, Valéry, Mouraux, André   +3 more
core  

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Role of Concentration in Opposing Effects of Anandamide on Nociceptive Synapses versus Non-nociceptive Synapses. [PDF]

eNeuro
Burrell BD.
europepmc   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

TRPA1 Integrates Nociceptive and Immune Signaling in <i>Hydra vulgaris</i>. [PDF]

Int J Mol Sci
D'Ezio V, Malafoglia V, Russo V, Ilari S, Proietti R, Muscoli C, Cianfanelli V, Spani F, Scalici M, Persichini T, Colasanti M.   +10 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Venlafaxine as Monotherapy and in Combination Regimens in Acute Rodent Nociception Experimental Models: A Review. [PDF]

Int J Mol Sci
Lungu C, Marin RC, Costescu M, Zugravu A, Paunescu H, Ghita CI, Coman OA.   +6 more
europepmc   +1 more source

Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats

European Journal of Oral Sciences, EarlyView.
Abstract Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood.
Joana Maria dos Santos Alves, Luiza Clertiani Vieira Alves, Vitória Tavares Bessa, Anamaria Falcão Pereira, Roberto César Pereira Lima Júnior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim   +7 more
wiley   +1 more source

Towards an individualised approach to pain management in inflammatory arthritis. [PDF]

Ther Adv Musculoskelet Dis
Rutter-Locher Z, Denk F, Taams LS, Kirkham BW, Bannister K.   +4 more
europepmc   +1 more source

Interactions between nociceptive and non-nociceptive afferent projections to cerebral cortex in humans.

, 1998
We investigated the effect of a tonic discharge of muscle nociceptive afferents on somatosensory evoked potentials (SEPs) in humans in response to stimulation of non-nociceptive afferents arising from the same muscle.
Groccia V, Spidalieri R., Decchi B, Della Volpe R, Rossi A   +4 more
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