Results 191 to 200 of about 89,362 (300)

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, EarlyView.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source

From Epithelial Sensing to Visceral Pain: Neuropod and Enterochromaffin Cells in Gut Neuroepithelial Circuits. [PDF]

Int J Mol Sci
Nowacka A, Śniegocki M, Ziółkowska EA.   +2 more
europepmc   +1 more source

Electroacupuncture and category IV LASER for treating suprascapular neuropathy in a two‐year‐old Arabian filly

Equine Veterinary Education, EarlyView.
Summary A 2‐year‐old Arabian filly presented with acute onset grade 4/5 (AAEP) right forelimb lameness and hindlimb ataxia following a collision with another horse and subsequent fall. The right forelimb lameness was associated with marked scapulohumeral joint instability.
O. E. Newman, B. Dunkel, M. Perrier
wiley   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Modulation of posterior insula selectively enhances nociceptive sensory gating in healthy humans. [PDF]

Neurobiol Pain
Legon W, Isaac G, Kapoor A, Strohman A.
europepmc   +1 more source

The pharmacology of gepants in migraine: A scoping review on mechanisms, clinical applications, and combination strategies

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background Calcitonin gene‐related peptide (CGRP) is a key mediator in migraine pathophysiology, and the development of gepants, novel CGRP receptor antagonists, has expanded therapeutic options for both acute and preventive treatment. This scoping review aims to synthesize current evidence on the pharmacology, clinical applications, safety ...
Luigi Francesco Iannone, Marcello Silvestro, Antonio Munafò, Marina Romozzi, Pierangelo Geppetti, Antonio Russo   +5 more
wiley   +1 more source

Cervical musculoskeletal function is variable in tension‐type headache: A cluster analysis

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives This study was conducted to (1) consider the causes of neck pain in tension‐type headache (TTH) by investigating how the patients with TTH, idiopathic neck pain (INP), and healthy controls group together based on the presence of cervical musculoskeletal dysfunction; and (2) determine any differences in TTH features, pain sensitivity,
Chalomjai Pensri, Zhiqi Liang, Julia Treleaven, Gwendolen Jull, Daniel Schweitzer, Lucy Thomas   +5 more
wiley   +1 more source

Factors Associated With Endodontic Flare‐Ups: A Systematic Review and Meta‐Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Background Endodontic flare‐ups, characterized by severe postoperative pain and/or swelling requiring unscheduled intervention, remain a clinically significant concern in root canal therapy. Identifying the factors associated with flare‐ups is important for anticipating and managing patient outcomes.
Jun Ohshima, Masayoshi Morita, Yuzo Kawanishi, Shotaro Abe, Nobutake Tanaka, Tsuyoshi Shimaoka, Hazuki Maezono, Yoshifumi Kinomoto, Mikako Hayashi   +8 more
wiley   +1 more source

RGS6 regulates Kappa opioid receptor-mediated antinociceptive behaviors. [PDF]

Neuropharmacology
Blount AP, Sutton LP.
europepmc   +1 more source

Clinical and Psychosocial Predisposing Factors Associated With Anaesthesia Failure During Non‐Surgical Root Canal Treatment: A National Dental Practice‐Based Research Network Study

International Endodontic Journal, EarlyView.
ABSTRACT Aim This study aimed to identify dentist, patient, and pre‐treatment clinical characteristics associated with local anaesthesia failure during non‐surgical endodontic treatment. Methodology Data were collected from the National Dental Practice‐Based Research Network study entitled “Predicting Outcomes of Root Canal Treatment (PREDICT)”, which ...
Linda J. Liu, Ronald Ordinola‐Zapata, W. Craig Noblett, Ellen Funkhouser, Alan S. Law, Donald R. Nixdorf, Ernest W. N. Lam, Rahma Mungia, Gregg H. Gilbert, The National Dental Practice‐Based Research Network Collaborative Group   +9 more
wiley   +1 more source