Results 81 to 90 of about 89,362 (300)

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Role of NHE1 in Nociception [PDF]

Pain Research and Treatment, 2013
Intracellular pH is a fundamental parameter to cell function that requires tight homeostasis. In the absence of any regulation, excessive acidification of the cytosol would have the tendency to produce cellular damage. Mammalian Na+/H+exchangers (NHEs) are electroneutral Na+-dependent proteins that exchange extracellular Na+for intracellular H+.
Jorge Elías Torres-López, Crystell Guadalupe Guzmán-Priego, Héctor Isaac Rocha-González, Vinicio Granados-Soto   +3 more
openaire   +2 more sources

Theta burst stimulation applied over primary motor and somatosensory cortices produces analgesia unrelated to the changes in nociceptive event-related potentials.

PLoS ONE, 2013
Continuous theta burst stimulation (cTBS) applied over the primary motor cortex (M1) can alleviate pain although the neural basis of this effect remains largely unknown.
Diana M E Torta, Valéry Legrain, Maxime Algoet, Etienne Olivier, Julie Duque, André Mouraux   +5 more
doaj   +1 more source

P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine?

, 2002
The discovery of mis-sense mutations in the alpha1A subunit of the P/Q-type calcium channel in patients with familial hemiplegic migraine indicates the potential involvement of dysfunctional ion channels in migraine.
Goadsby, PJ, Yolande E. Knight, Knight, Yolande E., Knight, YE, Goadsby, Peter J., Bartsch, Thorsten, Peter J. Goadsby, Kaube, Holger, Holger Kaube, Kaube, H, Thorsten Bartsch, Bartsch, T   +11 more
core   +1 more source

Retina‐Inspired Bi‐Based Terahertz Photonic Neuromorphic Devices

Advanced Science, EarlyView.
Combined with effective band alignment and substrate engineering, bismuth materials are introduced to form terahertz photonic bio‐inspired devices with picosecond short‐term plasticity to enable multi‐scene visual perception. Thus obtained hardware through the terahertz optical neural network (THz‐ONN) demonstrates high recognition accuracy, providing ...
Pujing Zhang, Donggang Xie, Longyu Shi, Mengyuan Wang, Huiwen Shi, Yu Wu, Menglei Li, Guangwei She, Peijie Wang, Wensheng Shi, Cunlin Zhang, Kuijuan Jin, Guozhen Yang, Qingli Zhou, Chen Ge   +14 more
wiley   +1 more source

Tratamiento del dolor en enfermedad terminal

Revista de Medicina e Investigación Universidad Autónoma del Estado de México
The management of analgesia is of great importance in terminal ill-ness, as it helps to have an adequate quality of life, when the goal of medical care is well-being and comfort, rather than overbur-dening efforts in prolonging life.
Andrés Antonio Navarro Palemón, Víctor Cortés Sánchez   +1 more
doaj   +1 more source

The human operculo-insular cortex is pain-preferentially but not pain-exclusively activated by trigeminal and olfactory stimuli. [PDF]

PLoS ONE, 2012
Increasing evidence about the central nervous representation of pain in the brain suggests that the operculo-insular cortex is a crucial part of the pain matrix.
Jörn Lötsch, Carmen Walter, Lisa Felden, Ulrike Nöth, Ralf Deichmann, Bruno G Oertel   +5 more
doaj   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Phenotyping of isolated mesh associated pain secondary to continence mesh device insertion

Frontiers in Pain Research
IntroductionIsolated Mesh associated Pain Syndrome (I-MAPS) is the most common complication of continence mesh devices. The pain mechanism involved remains unknown.
Hawra Badri, Hawra Badri, Hawra Badri, Karen Ward, Karen Ward, Richard Edmondson, Richard Edmondson, Richard Edmondson, Fiona Reid, Fiona Reid, Fiona Reid   +10 more
doaj   +1 more source

Controlling attention to nociceptive stimuli with working memory. [PDF]

PLoS ONE, 2011
BACKGROUND: Because pain often signals the occurrence of potential tissue damage, a nociceptive stimulus has the capacity to involuntarily capture attention and take priority over other sensory inputs.
Valéry Legrain, Geert Crombez, André Mouraux   +2 more
doaj   +1 more source