Results 101 to 110 of about 97,568 (259)
MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice
Arthritis &Rheumatology, Accepted Article.Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez +13 more
wiley +1 more source
The role of nociceptive neurons in allergic rhinitis
Frontiers in ImmunologyAllergic rhinitis (AR) is a chronic, non-infectious condition affecting the nasal mucosa, primarily mediated mainly by IgE. Recent studies reveal that AR is intricately associated not only with type 2 immunity but also with neuroimmunity.
Jianchao Cong +7 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley +1 more source
Nociceptive Laser-Evoked Brain Potentials Do Not Reflect Nociceptive-Specific Neural Activity
, 2009 Brief radiant laser pulses can be used to activate cutaneous Adelta and C nociceptors selectively and elicit a number of transient brain responses [laser-evoked potentials (LEPs)] in the ongoing EEG.
A. Mouraux +3 more
core +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard +3 more
wiley +1 more source
, 2018 Ryousuke Nakajima,1 Airi Uehara,1 Shiori Takehana,1 Youichi Akama,2 Yoshihito Shimazu,1 Mamoru Takeda1 1Laboratory of Food and Physiological Sciences, Department of Life and Food Sciences, School of Life and Environmental Sciences, Azabu University, Chuo-
Akama Y +5 more
core
Sensory changes in the forehead of patients with complex regional pain syndrome [PDF]
, 2006 The aim of this study was to investigate involvement of central mechanisms in complex regional pain syndrome (CRPS). In particular, we wished to determine whether hyperalgesia extends ipsilaterally from the affected limb to the forehead.
Drummond, P.D., Finch, P.M.
core
Direct cortical stimulation–evoked symptoms in the human temporal pole: A systematic review
Epileptic Disorders, EarlyView.Abstract The temporal pole represents a key node within temporolimbic networks and may contribute to seizure generation in temporal lobe epilepsy. Direct cortical stimulation (DCS), performed during intracranial presurgical evaluation, is a valuable method for delineating the seizure onset zone by reproducing electro‐clinical features of a patient's ...
Yulia Novitskaya +1 more
wiley +1 more source
Nociceptive and non-nociceptive steady-state evoked potentials tag distinct cortical network.
, 2011 The periodic presentation of a sensory stimulus induces, at certain frequencies of stimulation, a sustained electroencephalographic response known as steady-state evoked potentials (SSEP).
Colon, Elisabeth +4 more
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