Results 61 to 70 of about 89,362 (300)

Realization of nociceptive receptors based on Mott memristors

Applied Physics Express
Nociceptive receptors are primarily responsible for detecting and responding to potentially harmful stimuli, including painful sensations and tissue damage.
Yanji Wang, Yu Wang, Yanzhong Zhang, Xinpeng Wang, Hao Zhang, Rongqing Xu, Yi Tong   +6 more
doaj   +1 more source

Medical and sociological study of chronic pain problems associated with combat trauma

Медицина неотложных состояний
Background. Objective: to present the results of a sociological study on pain problems related to combat injury. Materials and methods. Analytical and statistical methods were used in the study.
А.М. Строкань, О.А. Лоскутов, Д.В. Дмитрієв, В.В. Марцінів, О.В. Клименко, А.М. Хоменко, А.М. Антофійчук, Р.Є. Седлецький, Р.О. Німкович   +8 more
doaj   +1 more source

Differential Modulation of Nociceptive versus Non-Nociceptive Synapses by Endocannabinoids

Molecular Pain, 2013
Background Although a number of clinical and preclinical studies have demonstrated analgesic effects of cannabinoid treatments, there are also instances when cannabinoids have had no effect or even exacerbated pain.
Alexandra Higgins, Sharleen Yuan, Yanqing Wang, Brian D Burrell   +3 more
doaj   +1 more source

The Role of Kv7/M Potassium Channels in Controlling Ectopic Firing in Nociceptors

Frontiers in Molecular Neuroscience, 2017
Peripheral nociceptive neurons encode and convey injury-inducing stimuli toward the central nervous system. In normal conditions, tight control of nociceptive resting potential prevents their spontaneous activation.
Omer Barkai, Omer Barkai, Robert H. Goldstein, Robert H. Goldstein, Yaki Caspi, Yaki Caspi, Ben Katz, Ben Katz, Shaya Lev, Shaya Lev, Alexander M. Binshtok, Alexander M. Binshtok   +11 more
doaj   +1 more source

Quantitative assessment of nociceptive processes in conscious dogs by use of the nociceptive withdrawal reflex

, 2006
OBJECTIVE: To investigate the feasibility of evoking the nociceptive withdrawal reflex (NWR) from fore and hind limbs in conscious dogs, score stimulus-associated behavioral responses, and assess the canine NWR response to suprathreshold stimulations ...
Spadavecchia, Claudia, Andersen, Ole K, Arendt-Nielsen, Lars, Bergadano, Alessandra, Schatzmann, Urs, Andersen, Ole K.; id_orcid   +5 more
core   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

In-silico Analysis and Anti-inflammatory Evaluation of Synthesized Amide Derivatives of Long-chain Fatty Acids [PDF]

Pharmaceutical and Biomedical Research
Background: The search for more active and less toxic anti-inflammatory drugs is the desire of every medicinal chemist. Amide derivatives of fatty acids (FAs) have diverse biological functions.
Samuel J. Bunu, Haruna Baba, Deghinmotei Alfred-Ugbenbo   +2 more
doaj  

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Nociception and the neonatal brain [PDF]

Seminars in Fetal and Neonatal Medicine, 2019
Measuring brain activity in infants provides an objective surrogate approach with which to infer pain perception following noxious events. Here we discuss different approaches which can be used to measure noxious-evoked brain activity, and discuss how these measures can be used to assess the analgesic efficacy of pharmacological and non-pharmacological
Gursul, Deniz, Hartley, Caroline, Slater, Rebeccah   +2 more
openaire   +2 more sources

Nociceptive Cortical Activity Is Dissociated from Nociceptive Behavior in Newborn Human Infants under Stress [PDF]

, 2017
Newborn infants display strong nociceptive behavior in response to tissue damaging stimuli, and this is accompanied by nociceptive activity generated in subcortical and cortical areas of the brain [1, 2].
Maria Fitzgerald, Laura Jones, Madeleine Verriotis, Jones, Laura, Meek, Judith, Fabrizi, Lorenzo, Judith Meek, Maria Laudiano-Dray, Lorenzo Fabrizi, Verriotis, Madeleine, Whitehead, Kimberley; id_orcid, Kimberley Whitehead, Laudiano-Dray, Maria, Fitzgerald, Maria   +13 more
core   +2 more sources