Results 61 to 70 of about 97,568 (259)

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Realization of nociceptive receptors based on Mott memristors

Applied Physics Express
Nociceptive receptors are primarily responsible for detecting and responding to potentially harmful stimuli, including painful sensations and tissue damage.
Yanji Wang, Yu Wang, Yanzhong Zhang, Xinpeng Wang, Hao Zhang, Rongqing Xu, Yi Tong   +6 more
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

Amygdala-prefrontal pathways and the dopamine system affect nociceptive responses in the prefrontal cortex

BMC Neuroscience, 2011
Background We previously demonstrated nociceptive discharges to be evoked by mechanical noxious stimulation in the prefrontal cortex (PFC). The nociceptive responses recorded in the PFC are conceivably involved in the affective rather than the sensory ...
Onozawa Kitaro, Yagasaki Yuki, Izawa Yumi, Abe Hiroyuki, Kawakami Yoriko   +4 more
doaj   +1 more source

EEG frequency-tagging to dissociate the cortical responses to nociceptive and non-nociceptive stimuli.

, 2014
Whether the cortical processing of nociceptive input relies on the activity of nociceptive-specific neurons or whether it relies on the activity of neurons also involved in processing non-nociceptive sensory input remains a matter of debate.
Colon, Elisabeth, Legrain, Valéry, Mouraux, André   +2 more
core   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Tratamiento del dolor en enfermedad terminal

Revista de Medicina e Investigación Universidad Autónoma del Estado de México
The management of analgesia is of great importance in terminal ill-ness, as it helps to have an adequate quality of life, when the goal of medical care is well-being and comfort, rather than overbur-dening efforts in prolonging life.
Andrés Antonio Navarro Palemón, Víctor Cortés Sánchez   +1 more
doaj   +1 more source

Pain hypersensitivity and spinal nociceptive hypersensitivity in chronic pain: prevalence and associated factors. [PDF]

, 2015
Hypersensitivity of pain pathways is considered a relevant determinant of symptoms in chronic pain patients, but data on its prevalence are very limited. To our knowledge, no data on the prevalence of spinal nociceptive hypersensitivity are available. We
Andersen, Ole Kæseler; id_orcid, Andersen, Ole K, Arendt-Nielsen, Lars, Müller, Monika, Ashraf, Aroosiah, Neziri, Alban Y., Streitberger, Konrad, Curatolo, Michele, Streitberger, Konrad Markus   +8 more
core   +1 more source

Multi‐Modal Low‐Power Adaptive Braille Recognition System Based on Hf0.3Zr0.7O2 Memristor

Advanced Science, EarlyView.
A multimodal adaptive perception system based on HZO ferroelectric memristor realizes efficient Braille digit recognition via reservoir computing. It delivers high recognition accuracy with ultralow‑energy analog computation, offering a promising hardware solution for environment‑robust neuromorphic assistive devices for visually impaired users ...
Jikang Xu, Jiacheng Wang, Ziye Li, Weidong Sun, Jianlin Wang, Qiang Lu, Wenjing Liu, Xiaoyang Liu, Yan Sun, Xiaobing Yan   +9 more
wiley   +1 more source

Phenotyping of isolated mesh associated pain secondary to continence mesh device insertion

Frontiers in Pain Research
IntroductionIsolated Mesh associated Pain Syndrome (I-MAPS) is the most common complication of continence mesh devices. The pain mechanism involved remains unknown.
Hawra Badri, Hawra Badri, Hawra Badri, Karen Ward, Karen Ward, Richard Edmondson, Richard Edmondson, Richard Edmondson, Fiona Reid, Fiona Reid, Fiona Reid   +10 more
doaj   +1 more source