Results 41 to 50 of about 89,362 (300)
Pain in the Blood? Envisioning Mechanism-Based Diagnoses and Biomarkers in Clinical Pain Medicine
Diagnostics, 2015 Chronic pain is highly prevalent, and pain medicine lacks objective biomarkers to guide diagnosis and choice of treatment. The current U.S. “opioid epidemic” is a reminder of the paucity of effective and safe treatment options. Traditional pain diagnoses
Emmanuel Bäckryd
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Frontiers in Pharmacology, 2020 The involvement of spinal release of histamine in the nociceptive behaviors induced by cholecystokinin-8 (CCK-8) was investigated in mice. Intrathecal (i.t.) injection of CCK-8 elicited the nociceptive behaviors consisting of biting and licking.
Takafumi Hayashi +7 more
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Classical analgesic drugs modulate nociceptive-like escape behavior in Drosophila melanogaster larvae [PDF]
Research Results in Pharmacology, 2022 Introduction: Nociceptive stimulus triggers escape responses in Drosophila melanogaster larvae, characterized by 360° rolling behavior along its own body axis.
Thamyris Santos-Silva +7 more
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Marine Drugs, 2013 A novel peptide, RsXXIVA, was isolated from the venom duct of Conus regularis, a worm-hunting species collected in the Sea of Cortez, México. Its primary structure was determined by mass spectrometry and confirmed by automated Edman degradation.
Lourival D. Possani +10 more
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Fine-grained nociceptive maps in primary somatosensory cortex
, 2012 Topographic maps of the receptive surface are a fundamental feature of neural organization in many sensory systems. While touch is finely mapped in the cerebral cortex, it remains controversial how precise any cortical nociceptive map may be.
Longo, Matthew R. +10 more
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Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice
, 2007 Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Geisslinger, Gerd +17 more
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Molecular Brain, 2020 The roles of serotonergic and noradrenergic signaling in nociceptive processing in the central nervous system are well known. However, dopaminergic signaling is also relevant to various physical functions, including nociception.
Shunpei Moriya +6 more
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The Neurobiology of Nociceptive and Anti-nociceptive Systems
Pain Physician, 2005 Pain is both a sensory event of the peripheral and central nervous systems and an experience that arises from, and reciprocally can affect processes of higher consciousness. Alterations in peripheral and central neuraxes can lead to sensitization, structural modification and long-term potentiation that can overcome modulatory influence(s) and change ...
openaire +2 more sources
A possible role of the locus coeruleus in complex regional pain syndrome
, 2012 Heightened sensitivity to painful stimulation commonly spreads from the affected limb to the ipsilateral forehead in patients with complex regional pain syndrome (CRPS).
Peter D Drummond +2 more
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Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity [PDF]
, 2012 Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.
Todd, A. J. +102 more
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