Results 21 to 30 of about 97,568 (259)

Anti- and Pro-Nociceptive Mechanisms in Neuropathic Pain after Human Spinal Cord Injury. [PDF]

, 2022
BACKGROUND Deficient endogenous pain modulation and increased nociceptive excitability are key features of central sensitization and can be assessed in humans by conditioned pain modulation (CPM, anti-nociceptive) and temporal summation of pain (TSP ...
Schweinhardt, Petra, Hubli, Michèle, Lütolf, Robin, Iara De Schoenmacker, Rosner, Jan, Laura Sirucek, Petra Schweinhardt, Robin Lütolf, Armin Curt, De Schoenmacker, Iara, Curt, Armin, Michèle Hubli, Sirucek, Laura, Jan Rosner   +13 more
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Lateral preoptic area glutamate neurons relay nociceptive information to the ventral tegmental area

Cell Reports, 2023
Summary: The ventral tegmental area (VTA) has been proposed to play a role in pain, but the brain structures modulating VTA activity in response to nociceptive stimuli remain unclear.
David J. Barker, Shiliang Zhang, Huiling Wang, David J. Estrin, Jorge Miranda-Barrientos, Bing Liu, Rucha J. Kulkarni, Junia Lara de Deus, Marisela Morales   +8 more
doaj   +1 more source

P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine? [PDF]

, 2002
The discovery of mis-sense mutations in the alpha1A subunit of the P/Q-type calcium channel in patients with familial hemiplegic migraine indicates the potential involvement of dysfunctional ion channels in migraine.
Goadsby, PJ, Yolande E. Knight, Knight, Yolande E., Knight, YE, Goadsby, Peter J., Bartsch, Thorsten, Peter J. Goadsby, Kaube, Holger, Holger Kaube, Kaube, H, Thorsten Bartsch, Bartsch, T   +11 more
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Nociceptive assays.

, 2023
(A) Nociceptive behavior was evaluated in C57BL/6 male mice (n = 6) using 0.5 μg paw injections of TsV and isolated toxins (Ts1, Ts5, Ts8, Ts19 frag II).
Thiago Cunha (3564422), Isadora Oliveira (11688997), Eliane Arantes (3425615), Wuelton Monteiro (752733), Karla Bordon (14522558), Manuela Pucca (3477908), Felipe Cerni (3477902), Isabela Ferreira (14522561), Francielle Cordeiro (14522555)   +8 more
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Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity [PDF]

, 2012
Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.
Todd, A. J., Martina Kurejova, Thomas Kuner, Irmgard Tegeder (179372), Hu, S.J., Kurejova Martina, Bali, K.K., Agarwal, Nitin, Anke Tappe-Theodor, Bali, Kiran Kumar, Polgar Erika, Franz Hofmann (179398), Todd, A.J., Lewin, G., Kuner Thomas, Ceng Luo (179354), Feil, Robert, Jens Schlossmann, Polgar, E., Gangadharan Vijayan, Andrew J Todd, Kurejova, Martina, Feil, Susanne, Ceng Luo, Hu, S., Susanne Feil (179376), Andrew J. Todd (179384), Feil, R., Rohini Kuner (179428), Erika Polgar (5649442), Rohini Kuner, Hu, San-Jue, Liu Da-Lu, Liu, D., Kuner, Thomas, San-Jue Hu (179417), Feil, S., Tegeder, Irmgard, Tappe-Theodor Anke, Kuner, R., Nitin Agarwal (179363), Robert Feil (28669), Agarwal, N., Agarwal Nitin, Xie, R.G., Robert Feil, Kiran Kumar Bali (179358), Da-Lu Liu (179408), Erika Polgar, Kuner, T., Tappe, Anke, Gary Lewin (179380), Liu, Da-Lu, Xie, R. G., Jens Schlossmann (179389), Nitin Agarwal, Luo, Ceng, Luo, C., Vijayan Gangadharan, Hu, S. J., Xie, Rou-Gang, Hofmann Franz, Da-Lu Liu, Rou-Gang Xie (179362), Bali Kiran Kumar, Tappe-Theodor, A., Kuner, Rohini, Lewin Gary, Liu, D. L., Kiran Kumar Bali, Irmgard Tegeder, Polgár, Erika, Hofmann, Franz, Tegeder Irmgard, Vijayan Gangadharan (179356), Rou-Gang Xie, Schlossmann Jens, Franz Hofmann, Feil Susanne, Hu San-Jue, San-Jue Hu, Xie Rou-Gang, Gangadharan, Vijayan, Todd Andrew J., Feil Robert, Martina Kurejova (179365), Bali, K. K., Gary Lewin, Susanne Feil, Anke Tappe-Theodor (179367), Lewin, Gary R., Schlossmann, Jens, Liu, D.L., Thomas Kuner (162293), Schlossmann, J., Luo Ceng, Gangadharan, V., Hofmann, F., Kuner Rohini, Todd, Andrew J., Xie, R., Tegeder, I., Kurejova, M., Luo, C;Gangadharan, V;Bali, KK;Xie, RG;Agarwal, N;Kurejova, M;Tappe-Theodor, A;Tegeder, I;Feil, S;Lewin, G;Polgar, E;Todd, AJ;Schlossmann, J;Hofmann, F;Liu, DL;Hu, SJ;Feil, R;Kuner, T;Kuner, R   +103 more
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Maternal presence or absence alters nociceptive responding and cortical anandamide levels in juvenile female rats [PDF]

, 2020
The influence of parental support on child pain experiences is well recognised. Accordingly, animal studies have revealed both short- and long-term effects of early life stress on nociceptive responding and neural substrates such as endocannabinoids. The
Kerr, Daniel M., McGuire, Brian E, Humphrey, Rachel M, Caes, Line, Thornton, Aoife M., Roche, Michelle, Humphrey, Rachel M., McGuire, Brian E., Kerr, Daniel M, O’Sullivan, Grace, Thornton, Aoife M   +10 more
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Biomechanical aspects of nonspecific back pain [PDF]

Universa Medicina, 2010
Low back pain (LBP) is a common problem in adult life, since despite its benign nature it is commonly associated with incapacity, productivity loss due to sick leave, and correspondingly high costs to the individual worker.
Ridwan Harrianto
doaj  

Back pain

Pediatria i Medycyna Rodzinna, 2014
Back pain is a symptom of a number of underlying diseases. The pain syndrome may be due to disorders of bone structures, apophyseal joints, ligaments, fascia, muscles or intervertebral discs, subsequently affecting or not the spinal cord and peripheral
Iwan Milanow
doaj   +1 more source

STAT3 Inhibition in a Murine Model of Human Breast Cancer-Induced Bone Pain Delays Onset of Nociception

Canadian Journal of Pain, 2019
Introduction/Aim: Alterations in extracellular glutamate levels have been previously found to contribute to cancer-induced bone pain (CIBP). Increased activity of system xc-, a cystine-glutamate membrane antiporter, has been previously implicated in our ...
Manu Sharma, Katja Linher-Melville, Jesse Sidhu, Peter Nakhla, Gurmit Singh   +4 more
doaj   +1 more source

Pain in the Blood? Envisioning Mechanism-Based Diagnoses and Biomarkers in Clinical Pain Medicine

Diagnostics, 2015
Chronic pain is highly prevalent, and pain medicine lacks objective biomarkers to guide diagnosis and choice of treatment. The current U.S. “opioid epidemic” is a reminder of the paucity of effective and safe treatment options. Traditional pain diagnoses
Emmanuel Bäckryd
doaj   +1 more source