Scientific Reports, 2017 The endocannabinoid system is thought to modulate nociceptive signaling making it a potential therapeutic target for treating pain. However, there is evidence that endocannabinoids have both pro- and anti-nociceptive effects.
Torrie Summers +3 more
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Fine-grained nociceptive maps in primary somatosensory cortex [PDF]
, 2012 Topographic maps of the receptive surface are a fundamental feature of neural organization in many sensory systems. While touch is finely mapped in the cerebral cortex, it remains controversial how precise any cortical nociceptive map may be.
Longo, Matthew R. +10 more
core +1 more source
Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]
, 2007 Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Geisslinger, Gerd +17 more
core +1 more source
A possible role of the locus coeruleus in complex regional pain syndrome [PDF]
, 2012 Heightened sensitivity to painful stimulation commonly spreads from the affected limb to the ipsilateral forehead in patients with complex regional pain syndrome (CRPS).
Peter D Drummond +2 more
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Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]
, 2006 Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Fang, Xin, Dr. +17 more
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Biomechanical aspects of nonspesific low back pain
Universa Medicina, 2016 Low back pain (LBP) is a common problem in adult life, since despite its benign nature it is commonly associated with incapacity, productivity loss due to sick leave, and correspondingly high costs to the individual worker.
Ridwan Harrianto
doaj +1 more source
Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]
, 2009 Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Brugger, Stefan +21 more
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Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]
, 2011 Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Geisslinger, Gerd +39 more
core +3 more sources
Neuroimmunological mechanisms of chronic pain syndrome
Неврология, нейропсихиатрия, психосоматика, 2016 The article considers the mechanisms of chronic low back pain. Three pathophysiological mechanisms: nociceptive, neurogenic (neuropathic), and psychogenic are noted to be involved in the development of pain syndrome.
I. A. Vyshlova +2 more
doaj +1 more source
Orienting attention modulates pain perception: an ERP study. [PDF]
PLoS ONE, 2012 INTRODUCTION: Research has shown that people with chronic pain have difficulty directing their attention away from pain. A mental strategy that incorporates focused attention and distraction has been found to modulate the perception of pain intensity ...
Sam C C Chan +4 more
doaj +1 more source