Results 11 to 20 of about 1,073,273 (204)

A possible role of the locus coeruleus in complex regional pain syndrome [PDF]

Frontiers in Integrative Neuroscience, 2012
Heightened sensitivity to painful stimulation commonly spreads from the affected limb to the ipsilateral forehead in patients with complex regional pain syndrome (CRPS).
Peter D Drummond
doaj   +2 more sources

Nrxn3 reduces myofascial nociceptive pain. [PDF]

Neurobiol Pain
Neurexin 3 (Nrxn3) has a role in neuronal signaling. Previous reports indicated that reducing Nrxn3 expression in the central amygdala increased orofacial neuropathic pain. A common temporomandibular disorder is myofascial pain. Thus, we hypothesized that Nrxn3 would reduce myofascial hypersensitivity.
Nguyen L, Umorin M, Kramer PR.
europepmc   +4 more sources

Capsaicin, Nociception and Pain [PDF]

Molecules, 2016
Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved in somatic and visceral peripheral inflammation, in the modulation of nociceptive inputs to spinal cord and brain stem centers, as well as the integration of diverse ...
Frias, Bárbara, MERIGHI, Adalberto
openaire   +4 more sources

Pain-autonomic measures reveal nociceptive sensitization in complex regional pain syndrome. [PDF]

, 2023
BACKGROUND Allodynia and hyperalgesia are common signs in individuals with complex regional pain syndrome (CRPS), mainly attributed to sensitization of the nociceptive system.
Rosner, J, De Schoenmacker, I, Paulina S. Scheuren, Iara De Schoenmacker, Hubli, M, Florian Brunner, Armin Curt, Hubli, Michèle; https://orcid.org/, Brunner, F, De Schoenmacker, Iara, Curt, Armin, Michèle Hubli, Curt, A, Scheuren, Paulina S; https://orcid.org/, Rosner, Jan; https://orcid.org/, Jan Rosner, Scheuren, P S, Brunner, Florian   +17 more
core   +3 more sources

Anticipation of pain enhances the nociceptive transmission and functional connectivity within pain network in rats [PDF]

, 2008
Background: Expectation is a very potent pain modulator in both humans and animals. There is evidence that pain transmission neurons are modulated by expectation preceding painful stimuli.
Zhang, Han-Ti, J. Y. Wang, Luo, Fei, Woodward, Donald J., Baccala, Luiz A., Wang, Jin-Yan, Chang, Jing-Yu   +6 more
core   +3 more sources

TRPA1 as a therapeutic target for nociceptive pain. [PDF]

Expert Opin Ther Targets, 2020
Chronic pain affects approximatively 30-50% of the population globally. Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with chemotherapeutic agents, can induce chronic pain. Members of the transient receptor potential (TRP) channels, including the TRP ankyrin 1 (TRPA1), have a major role in pain.We focus on TRPA1 as a ...
Souza Monteiro de Araujo D, Nassini R, Geppetti P, De Logu F.   +3 more
europepmc   +5 more sources

Serum Biomarkers of Nociceptive and Neuropathic Pain in Chronic Pancreatitis [PDF]

, 2023
Debilitating abdominal pain is a common symptom affecting most patients with chronic pancreatitis (CP). There are multiple underlying mechanisms that contribute to CP-related pain, which makes successful treatment difficult.
Phil A. Hart, Dhiraj Yadav, Anna Evans Phillips, Saloman, Jami L., Mark D. Topazian, Andersen, Dana K, Liang Li, Topazian, Mark D., Pandol, Stephen J., Hart, Phil A, Yadav, Dhiraj, Kimberly Stello, Wenhao Li, Li, Shuang, Dana K. Andersen, Vege, Santhi Swaroop, Walter G. Park, Park, Walter G., Fisher, William E., William E. Fisher, Saloman, Jami L, Fogel, Evan L, Serrano, Jose, Stephen K. Van Den Eeden, Evans Phillips, Anna, Christopher E. Forsmark, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC), Kristen Hall, Li, Liang, Li, Yan, Van Den Eeden, Stephen K., Jami L. Saloman, Van Den Eeden, Stephen K, Hall, Kristen, Yan Li, Darwin L. Conwell, Andersen, Dana K., Conwell, Darwin L, Shuang Li, Topazian, Mark D, Jose Serrano, Fogel, Evan L., Stello, Kimberly, Pandol, Stephen J, Conwell, Darwin L., Park, Walter G, Evan L. Fogel, Li, Wenhao, Fisher, William E, Santhi Swaroop Vege, Hart, Phil A., Forsmark, Christopher E, Stephen J. Pandol, Phillips, Anna Evans, Forsmark, Christopher E.   +54 more
core   +1 more source

Anti- and Pro-Nociceptive Mechanisms in Neuropathic Pain after Human Spinal Cord Injury. [PDF]

, 2022
BACKGROUND Deficient endogenous pain modulation and increased nociceptive excitability are key features of central sensitization and can be assessed in humans by conditioned pain modulation (CPM, anti-nociceptive) and temporal summation of pain (TSP ...
Schweinhardt, Petra, Hubli, Michèle, Lütolf, Robin, Iara De Schoenmacker, Rosner, Jan, Laura Sirucek, Petra Schweinhardt, Robin Lütolf, Armin Curt, De Schoenmacker, Iara, Curt, Armin, Michèle Hubli, Sirucek, Laura, Jan Rosner   +13 more
core   +3 more sources

Fine-grained nociceptive maps in primary somatosensory cortex [PDF]

, 2012
Topographic maps of the receptive surface are a fundamental feature of neural organization in many sensory systems. While touch is finely mapped in the cerebral cortex, it remains controversial how precise any cortical nociceptive map may be.
Longo, Matthew R., Iannetti, GD, Sereno, MI, Iannetti, G.D., Longo, MR, Haggard, P, ,, Mancini, F, Mancini, F., Haggard, P., Sereno, Martin I.   +10 more
core   +1 more source

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]

, 2007
Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Geisslinger, Gerd, Rolf M. Nusing, Gerd Geisslinger, Scholich, Klaus, Angioni, Carlo Federico, Klaus Scholich, Laura Popp, Brenneis, Christian, Ovidiu Coste, Becker, Wiebke, Popp, Laura, Nusing, Rolf M., Coste, Ovidiu, Carlo Angioni, Christian Brenneis, Ronald Schmidt, Wiebke Becker, Schmidt, Ronald   +17 more
core   +1 more source