Results 81 to 90 of about 1,073,273 (204)

Advances in understanding nociception and neuropathic pain [PDF]

Journal of Neurology, 2017
Pain results from the activation of a subset of sensory neurones termed nociceptors and has evolved as a "detect and protect" mechanism. However, lesion or disease in the sensory system can result in neuropathic pain, which serves no protective function.
openaire   +2 more sources

The Translational Studies of Pain: From Spinal Neurones to Human Perception [PDF]

, 2015
The discovery of new treatments for chronic pain relies on the detection of pre-clinical targets and the progression to successful clinical trials. In order to improve this transition reliable translational models must be identified, based on mechanisms ...
O'Neill, J
core  

The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain

Neurobiology of Disease, 2016
Neuropathic pain results from neuroplasticity in nociceptive neuronal networks. Here we demonstrate that control of alternative pre-mRNA splicing, through the splice factor serine-arginine splice factor 1 (SRSF1), is integral to the processing of ...
Richard P. Hulse, Robert A.R. Drake, David O. Bates, Lucy F. Donaldson   +3 more
doaj   +1 more source

The μ-opioid receptor differentiates two distinct human nociceptive populations relevant to clinical pain

Cell Reports Medicine
Summary: The shortfall in new analgesic agents is a major impediment to reducing reliance on opioid medications for control of severe pain. In both animals and man, attenuating nociceptive transmission from primary afferent neurons with a μ-opioid ...
Ellen S. Staedtler, Matthew R. Sapio, Diana M. King, Dragan Maric, Andre Ghetti, Andrew J. Mannes, Michael J. Iadarola   +6 more
doaj   +1 more source

Neonatal Sleep Restriction Increases Nociceptive Sensitivity in Adolescent Mice

, 2018
Background: Sleep loss in infants may have a negative effect on the functional and structural development of the nociceptive system. We tested the hypothesis that neonatal sleep restriction induces a long-term increase of pain-related behaviors in mice ...
Andersen, Monica Levy [UNIFESP], Tufik, Sergio [UNIFESP], Coelho, Cesar A. [UNIFESP], Araujo, Paula [UNIFESP], Oliveira, Maria G. [UNIFESP]   +4 more
core  

C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception

Molecular Pain, 2019
Sensitivity to different pain modalities has a genetic basis that remains largely unknown. Employing closely related inbred mouse substrains can facilitate gene mapping of nociceptive behaviors in preclinical pain models.
Camron D Bryant, Deniz Bagdas, Lisa R Goldberg, Tala Khalefa, Eric R Reed, Stacey L Kirkpatrick, Julia C Kelliher, Melanie M Chen, William E Johnson, Megan K Mulligan, M Imad Damaj   +10 more
doaj   +1 more source

A Comprehensive Review on the Regulatory Action of TRP Channels: A Potential Therapeutic Target for Nociceptive Pain. [PDF]

Neurosci Insights, 2023
Anand S, Rajagopal S.
europepmc   +1 more source

Persistence of pain induced by startle and forehead cooling after sympathetic blockade in patients with complex regional pain syndrome [PDF]

, 2004
Background: Stimuli arousing sympathetic activity can increase ratings of clinical pain in patients with complex regional pain syndrome (CRPS). Objective: To determine whether the increase in pain is mediated by peripheral sympathetic activity.
Drummond, P.D., Finch, P.M.
core  

The Ca²⁺ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain. [PDF]

Sci Signal, 2023
Son GY, Tu NH, Santi MD, Loya Lopez S, Souza Bomfim GH, Vinu M, Zhou F, Chaloemtoem A, Alhariri R, Idaghdour Y, Khanna R, Ye Y, Lacruz RS.   +12 more
europepmc   +1 more source

Investigating the diagnostic value of the pediatric critical care observation tool (P-CPOT) among children hospitalized in the pediatric intensive care unit in 2021- a comparative study

BMC Pediatrics
Background Effective pain management in the pediatric intensive care unit (PICU) relies on valid assessment tools. This study evaluated the Pediatric Critical Care Observation Tool (P-CPOT) for assessing pain in critically ill children. The objective was
Mohammad Salehpoor-Emran, Mojgan Panjo, Roghieh Nazari   +2 more
doaj   +1 more source