Results 71 to 80 of about 1,073,273 (204)

TRPA1 Antagonists for Pain Relief

Pharmaceuticals, 2018
Here, we review the literature assessing the role of transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable non-selective cation channel, in various types of pain conditions.
Ari Koivisto, Niina Jalava, Raymond Bratty, Antti Pertovaara   +3 more
doaj   +1 more source

The influence of discouragement, anxiety and anger on pain: an examination of the role of endogenous opioids [PDF]

, 2005
Animal research suggests that exposure to inescapable stressors can lead to an endogenous opioid-mediated form of pain inhibition, known as stress-induced analgesia (SIA).
Frew, Ashley Kim
core  

Is there a relationship between pain intensity and postural sway in patients with non-specific low back pain? [PDF]

, 2011
Background Increased center of pressure excursions are well documented in patients suffering from non-specific low back pain, whereby the altered postural sway includes both higher mean sway velocities and larger sway area.
Walker Bruce, Ruhe Alexander, Alexander Ruhe, Ruhe, A., Bruce Walker, Walker, B., Fejer, R., Fejer René, René Fejer   +8 more
core   +1 more source

Pain perception is increased in congenital but not late onset blindness.

PLoS ONE, 2014
There is now ample evidence that blind individuals outperform sighted individuals in various tasks involving the non-visual senses. In line with these results, we recently showed that visual deprivation from birth leads to an increased sensitivity to ...
Hocine Slimani, Sabrina Danti, Maurice Ptito, Ron Kupers   +3 more
doaj   +1 more source

Reticular Formation and Pain: The Past and the Future

Frontiers in Neuroanatomy, 2017
The involvement of the reticular formation (RF) in the transmission and modulation of nociceptive information has been extensively studied. The brainstem RF contains several areas which are targeted by spinal cord afferents conveying nociceptive input ...
Isabel Martins, Isabel Martins, Isabel Martins, Isabel Martins, Isaura Tavares, Isaura Tavares, Isaura Tavares, Isaura Tavares   +7 more
doaj   +1 more source

Antinociceptive activity of the S1P-receptor agonist FTY720 [PDF]

, 2008
FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist.
Geisslinger, Gerd, Gerd Geisslinger, Scholich, Klaus, Angioni, Carlo Federico, Klaus Scholich, Laura Popp, Sandra Pierre, Brenneis, Christian, Ovidiu Coste, Claudiu Marian, Marian, Claudiu, Popp, Laura, Coste, Ovidiu, Carlo Angioni, Schmidt, Helmut, Christian Brenneis, Pierre, Sandra, Helmut Schmidt   +17 more
core   +1 more source

Animal models of nociceptive pain

Current Issues in Pharmacy and Medical Sciences, 2010
Pain is one of the most common symptoms experienced by both humans and animals. In humans, unrelieved pain can disturb daily activities and quality of life.
Ewa Gibula-Bruzda
doaj  

The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation [PDF]

, 2005
Therapies directed against tumour necrosis factor (TNF) are effective for the treatment of rheumatoid arthritis and reduce pain scores in this condition.
Inglis, JJ, Lees, DM, Ahuva Nissim, Nissim, A, Bruce L Kidd, Kidd, BL, Julia J Inglis, Delphine M Lees, Hunt, SP, Chernajovsky, Y, Stephen P Hunt, Yuti Chernajovsky   +11 more
core   +1 more source

Investigation of the central molecular events that maintain persistent inflammatory pain states. [PDF]

, 2007
Noxious stimulation of the periphery leads to long-term changes in the excitability of dorsal horn neurons of the spinal cord. In the spinal cord the increased excitability of dorsal horn neurons requires the activation of a subset of superficial dorsal ...
Wong, Y.M.
core  

Association between pain threshold and manifested pain assessed using a PD-specific pain scale in Parkinson's disease

Frontiers in Neurology
BackgroundThe neurodegenerative process in Parkinson's disease (PD) affects both dopaminergic and non-dopaminergic structures, which determine the wide range of motor and non-motor symptoms (NMS), including different types of pain.
Galina Stoyanova-Piroth, Galina Stoyanova-Piroth, Ivan Milanov, Katerina Stambolieva   +3 more
doaj   +1 more source